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Clinicopathological and Prognostic Significance of Survivin Over-Expression in Patients with Esophageal Squamous Cell Carcinoma: A Meta-Analysis

Author

Listed:
  • Chunguang Li
  • Zhigang Li
  • Maoling Zhu
  • Tiejun Zhao
  • Ling Chen
  • Weidan Ji
  • Hezhong Chen
  • Changqing Su

Abstract

Background: The prognostic significance of survivin for survival of patients with esophageal squamous cell carcinoma (ESCC) remains controversial. Thus, meta-analysis of the literatures was performed in order to demonstrate its expression impact on ESCC clinicopathological features and prognosis. Methodology: Relevant literatures were searched using PubMed, EMBASE and Medline Databases. Revman5.0 software was used to pool eligible studies and summary hazard ratio (HR). Correlation between survivin expression and clinicopathological features of ESCC was analyzed. Principal Findings: Final analysis of 523 patients from 7 eligible studies was performed. Combined HR of survivin location in nuclei suggested that survivin expression has an unfavorable impact on ESCC patients' survival (n = 277 in 3 studies; HR = 1.89, 95% CI: 1.45–2.96; Z = 4.69; P

Suggested Citation

  • Chunguang Li & Zhigang Li & Maoling Zhu & Tiejun Zhao & Ling Chen & Weidan Ji & Hezhong Chen & Changqing Su, 2012. "Clinicopathological and Prognostic Significance of Survivin Over-Expression in Patients with Esophageal Squamous Cell Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    • Handle: RePEc:plo:pone00:0044764
    DOI: 10.1371/journal.pone.0044764
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    Cited by:

    1. Jin Long Liu & Wei Gao & Qing Min Kang & Xue Jun Zhang & Shu Guang Yang, 2013. "Prognostic Value of Survivin in Patients with Gastric Cancer: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    2. Ke-yan Cheng & Zhi-lian Wang & Qian-yun Gu & Min Hao, 2016. "Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-15, October.
    3. Jin Long Liu & Xue Jun Zhang & Zhao Zhang & An Hong Zhang & Wei Wang & Jia Hong Dong, 2013. "Meta-Analysis: Prognostic Value of Survivin in Patients with Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-10, December.
    4. Shang Xie & Hui Xu & Xiaofeng Shan & Baozhong Liu & Kan Wang & Zhigang Cai, 2015. "Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.

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