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Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis

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  • Andreas Krieg
  • Thomas A Werner
  • Pablo E Verde
  • Nikolas H Stoecklein
  • Wolfram T Knoefel

Abstract

Survivin/BIRC5 is a potentially interesting prognostic marker and therapeutic target in colorectal cancer (CRC). However, the available data on survivin expression in CRC are heterogeneous. Thus, to clarify the prognostic relevance of survivin in patients with CRC and its association with clinicopathological parameters we performed a meta-analysis. We screened PubMed and EMBASE for those studies that investigated the prognostic value of survivin and its association with clinicopathological parameters in CRC. Data from eligible studies were extracted and included into the meta-analyses using a random effects model. Electronical literature search identified 15 studies including 1934 patients with CRC mostly detecting survivin by immunohistochemistry (IHC). Pooled hazard ratios of 11 studies that performed survival analysis revealed a positive correlation between survivin expression and poor prognosis (HR 1.93; 95% CI: 1.55–2.42; P

Suggested Citation

  • Andreas Krieg & Thomas A Werner & Pablo E Verde & Nikolas H Stoecklein & Wolfram T Knoefel, 2013. "Prognostic and Clinicopathological Significance of Survivin in Colorectal Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    • Handle: RePEc:plo:pone00:0065338
    DOI: 10.1371/journal.pone.0065338
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    Cited by:

    1. Zhihong Zhao & Guixiang Liao & Yongqiang Li & Shulu Zhou & Hequn Zou & Samitha Fernando, 2014. "Prognostic Value of Carbonic Anhydrase IX Immunohistochemical Expression in Renal Cell Carcinoma: A Meta-Analysis of the Literature," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-16, November.
    2. Shang Xie & Hui Xu & Xiaofeng Shan & Baozhong Liu & Kan Wang & Zhigang Cai, 2015. "Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.

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