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Control of apoptosis and mitotic spindle checkpoint by survivin

Author

Listed:
  • Fengzhi Li

    (Boyer Center for Molecular Medicine, Yale University School of Medicine)

  • Grazia Ambrosini

    (Boyer Center for Molecular Medicine, Yale University School of Medicine)

  • Emily Y. Chu

    (Boyer Center for Molecular Medicine, Yale University School of Medicine)

  • Janet Plescia

    (Boyer Center for Molecular Medicine, Yale University School of Medicine)

  • Simona Tognin

    (DIBIT S. Raffaele Scientific Institute)

  • Pier Carlo Marchisio

    (DIBIT S. Raffaele Scientific Institute
    University of Torino)

  • Dario C. Altieri

    (Boyer Center for Molecular Medicine, Yale University School of Medicine)

Abstract

Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to be intimately linked processes1, acting to preserve homeostasis and developmental morphogenesis2. Although proteins that regulate apoptosis have been implicated in restraining cell-cycle entry3 and controlling ploidy (chromosome number)4, the effector molecules at the interface between cell proliferation and cell survival have remained elusive. Here we show that a new inhibitor of apoptosis (IAP) protein5,6, survivin7, is expressed in the G2/M phase of the cell cycle in a cycle-regulated manner. At the beginning of mitosis, survivin associates with microtubules of the mitotic spindle in a specific and saturable reaction that is regulated by microtubule dynamics8. Disruption of survivin–microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. These results indicate that survivin may counteract a default induction of apoptosis in G2/M phase. The overexpression of survivin in cancer7 may overcome this apoptotic checkpoint and favour aberrant progression of transformed cells through mitosis.

Suggested Citation

  • Fengzhi Li & Grazia Ambrosini & Emily Y. Chu & Janet Plescia & Simona Tognin & Pier Carlo Marchisio & Dario C. Altieri, 1998. "Control of apoptosis and mitotic spindle checkpoint by survivin," Nature, Nature, vol. 396(6711), pages 580-584, December.
  • Handle: RePEc:nat:nature:v:396:y:1998:i:6711:d:10.1038_25141
    DOI: 10.1038/25141
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    Cited by:

    1. Jin Long Liu & Wei Gao & Qing Min Kang & Xue Jun Zhang & Shu Guang Yang, 2013. "Prognostic Value of Survivin in Patients with Gastric Cancer: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    2. Ke-yan Cheng & Zhi-lian Wang & Qian-yun Gu & Min Hao, 2016. "Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-15, October.
    3. Dirke Imig & Nadine Pollak & Frank Allgöwer & Markus Rehm, 2020. "Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-17, June.
    4. Jin Long Liu & Xue Jun Zhang & Zhao Zhang & An Hong Zhang & Wei Wang & Jia Hong Dong, 2013. "Meta-Analysis: Prognostic Value of Survivin in Patients with Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-10, December.
    5. Nguyen Thi Phuong & Duong Thuc Huy & Nguyen Huu Hung, 2022. "Cytotoxic activity related to survivin mRNA levels by Combretum quadrangulare Kurz extract against liver and breast cancer cells," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 12(1), pages 55-64.
    6. Shang Xie & Hui Xu & Xiaofeng Shan & Baozhong Liu & Kan Wang & Zhigang Cai, 2015. "Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.

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