IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0165117.html
   My bibliography  Save this article

Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis

Author

Listed:
  • Ke-yan Cheng
  • Zhi-lian Wang
  • Qian-yun Gu
  • Min Hao

Abstract

Objective: Overexpression of survivin has been reported in many human tumors. However, the clinicopathological features associated with survivin overexpression in cervical carcinoma remain controversial. Thus, the current meta-analysis was performed to assess the clinicopathological significance of survivin in cervical carcinoma. Methods: PubMed, EMBASE, and Web of Science databases were searched for relevant studies published through November 1, 2015. A meta-analysis was performed to evaluate the association between survivin expression and clinicopathological outcome in cervical carcinoma. Results: Eleven eligible studies with a total of 865 patients were included. Survivin overexpression was closely related to lymph node metastasis (odds ratio [OR] = 0.679, 95% confidence interval [CI]: 0.509–0.905, P = 0.008) but was not significantly associated with tumor FIGO stage (I+II vs. III+IV) (OR = 0.843, 95% CI: 0.626–1.137, P = 0.264), tumor grade (G1+G2 vs. G3) (OR = 0.913, 95% CI: 0.689–1.210, P = 0.527), tumor size (>4 vs. ≤4 cm) (OR = 0.825, 95% CI: 0.434–1.570, P = 0.559), or stromal involvement (OR = 0.820, 95% CI: 0.545–1.233, P = 0.340). The correlation between survivin expression and overall survival was evaluated among a total of 238 patients from three eligible studies. The pooled HR was 1.129 (95% CI: 0.597–1.661; P = 0.000), indicating that survivin expression was significantly associated with poor survival in cervical carcinoma. Conclusions: Based on the current meta-analysis, survivin is strongly associated with lymph node metastasis and poor prognosis. Additionally, survivin is a novel clinicopathological marker of cervical carcinoma and thus may be a therapeutic target for cervical carcinoma.

Suggested Citation

  • Ke-yan Cheng & Zhi-lian Wang & Qian-yun Gu & Min Hao, 2016. "Survivin Overexpression Is Associated with Aggressive Clinicopathological Features in Cervical Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0165117
    DOI: 10.1371/journal.pone.0165117
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165117
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0165117&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0165117?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Chunguang Li & Zhigang Li & Maoling Zhu & Tiejun Zhao & Ling Chen & Weidan Ji & Hezhong Chen & Changqing Su, 2012. "Clinicopathological and Prognostic Significance of Survivin Over-Expression in Patients with Esophageal Squamous Cell Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. Fengzhi Li & Grazia Ambrosini & Emily Y. Chu & Janet Plescia & Simona Tognin & Pier Carlo Marchisio & Dario C. Altieri, 1998. "Control of apoptosis and mitotic spindle checkpoint by survivin," Nature, Nature, vol. 396(6711), pages 580-584, December.
    3. Lou Qian Zhang & Jun Wang & Feng Jiang & Lin Xu & Fu Yin Liu & Rong Yin, 2012. "Prognostic Value of Survivin in Patients with Non-Small Cell Lung Carcinoma: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-9, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jin Long Liu & Wei Gao & Qing Min Kang & Xue Jun Zhang & Shu Guang Yang, 2013. "Prognostic Value of Survivin in Patients with Gastric Cancer: A Systematic Review with Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-1, August.
    2. Jin Long Liu & Xue Jun Zhang & Zhao Zhang & An Hong Zhang & Wei Wang & Jia Hong Dong, 2013. "Meta-Analysis: Prognostic Value of Survivin in Patients with Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-10, December.
    3. Shang Xie & Hui Xu & Xiaofeng Shan & Baozhong Liu & Kan Wang & Zhigang Cai, 2015. "Clinicopathological and Prognostic Significance of Survivin Expression in Patients with Oral Squamous Cell Carcinoma: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-16, February.
    4. Kuangguo Zhou & Danmei Xu & Yang Cao & Jue Wang & Yunfan Yang & Mei Huang, 2014. "C-MYC Aberrations as Prognostic Factors in Diffuse Large B-cell Lymphoma: A Meta-Analysis of Epidemiological Studies," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.
    5. Dirke Imig & Nadine Pollak & Frank Allgöwer & Markus Rehm, 2020. "Sample-based modeling reveals bidirectional interplay between cell cycle progression and extrinsic apoptosis," PLOS Computational Biology, Public Library of Science, vol. 16(6), pages 1-17, June.
    6. Nguyen Thi Phuong & Duong Thuc Huy & Nguyen Huu Hung, 2022. "Cytotoxic activity related to survivin mRNA levels by Combretum quadrangulare Kurz extract against liver and breast cancer cells," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 12(1), pages 55-64.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0165117. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.