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E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis

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  • Gaojun Cai
  • Bifeng Zhang
  • Weijin Weng
  • Ganwei Shi
  • Sheliang Xue
  • Yanbin Song
  • Chunyan Ma

Abstract

Objective: Epidemiological studies have shown that E-selectin gene polymorphisms (A561C and C1839T) may be associated with essential hypertension (EH), but the results are conflicting in different ethnic populations. Thus, we performed this meta-analysis to investigate a more authentic association between E-selectin gene polymorphisms and the risk of EH. Methods: We searched the relevant studies for the present meta-analysis from the following electronic databases: PubMed, Embase, Cochrane Library, Google Scholar, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI). Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of the association between E-selectin gene polymorphisms and EH susceptibility. The pooled ORs were performed for dominant model, allelic model and recessive model. The publication bias was examined by Begg’s funnel plots and Egger’s test. Results: A total of eleven studies met the inclusion criteria. All studies came from Asians. Ten studies (12 cohorts) evaluated the A561C polymorphism and EH risk, including 2,813 cases and 2,817 controls. The pooled OR was 2.280 (95%CI: 1.893–2.748, P

Suggested Citation

  • Gaojun Cai & Bifeng Zhang & Weijin Weng & Ganwei Shi & Sheliang Xue & Yanbin Song & Chunyan Ma, 2014. "E-Selectin Gene Polymorphisms and Essential Hypertension in Asian Population: An Updated Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0102058
    DOI: 10.1371/journal.pone.0102058
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    References listed on IDEAS

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    1. Justin B Echouffo-Tcheugui & G David Batty & Mika Kivimäki & Andre P Kengne, 2013. "Risk Models to Predict Hypertension: A Systematic Review," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-10, July.
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