IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0080687.html
   My bibliography  Save this article

Genetic Polymorphisms of XRCC1 and Leukemia Risk: A Meta-Analysis of 19 Case-Control Studies

Author

Listed:
  • Haijun Zhang
  • Hang Liu
  • Gaofeng Jiang

Abstract

Objective: Three common X-ray repair cross-complementing groups 1 (XRCC1) polymorphisms, Arg399Gln, Arg194Trp, and Arg280His, have been reported to be implicated in the development of leukemia. However, previous results from different studies were inconsistent. Consequently, we performed a meta-analysis in order to accurately evaluate the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and leukemia risk. Methods: Through computerized searching of PubMed, ISI Web of Knowledge, Cochrane, EBSCO, and OpenGrey databases, and manually searching relevant references, a total of 19 studies with 3387 cases and 6168 controls for Arg399Gln (G>A) polymorphism, 12 studies with 2043 cases and 4550 controls for Arg194Trp (C>T), and 6 studies with 1445 cases and 1905 controls for Arg280His (G>A) were collected to perform meta-analysis and stratified analysis to explore the associations between these variants and leukemia susceptibility. Based on three genetic models, the codominant model, dominant model and recessive model, odds ratios (ORs) as well as their 95% confidence intervals (CIs) were used to evaluate the association strength between XRCC1 genotypes and leukemia risk. Results: With respect to overall leukemia susceptibility, no association was detected. In stratified analyses by tumor type, Arg399Gln was associated with higher acute lymphoblastic leukemia (ALL) risk (AA vs. GG, OR = 1.50, 95% CI: 1.11-2.02; AA+GA vs. GG, OR = 1.35, 95% CI: 1.02-1.78). Additionally, Arg399Gln, Arg194Trp, and Arg280His may influence the susceptibilities of some leukemia type and race populations. Conclusion: This meta-analysis indicates these three polymorphisms of XRCC1 do not associate with overall leukemia risks but could be associated with the risks for some specific subgroups.

Suggested Citation

  • Haijun Zhang & Hang Liu & Gaofeng Jiang, 2013. "Genetic Polymorphisms of XRCC1 and Leukemia Risk: A Meta-Analysis of 19 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0080687
    DOI: 10.1371/journal.pone.0080687
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080687
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0080687&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0080687?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Wen-Qi Ma & Xi-Qiong Han & Xin Wang & Ying Wang & Yi Zhu & Nai-Feng Liu, 2016. "Associations between XRCC1 Gene Polymorphisms and Coronary Artery Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-15, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qian Li & Yan Chen & Shikun Sun & Muyuan Zhu & Jing Xue & Zihan Gao & Jinfeng Zhao & Yihe Tang, 2022. "Research on Crop Irrigation Schedules Under Deficit Irrigation—A Meta-analysis," Water Resources Management: An International Journal, Published for the European Water Resources Association (EWRA), Springer;European Water Resources Association (EWRA), vol. 36(12), pages 4799-4817, September.
    2. Bart Verkuil & Serpil Atasayi & Marc L Molendijk, 2015. "Workplace Bullying and Mental Health: A Meta-Analysis on Cross-Sectional and Longitudinal Data," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    3. Damiano Pizzol & Mike Trott & Igor Grabovac & Mario Antunes & Anna Claudia Colangelo & Simona Ippoliti & Cristian Petre Ilie & Anne Carrie & Nicola Veronese & Lee Smith, 2021. "Laparoscopy in Low-Income Countries: 10-Year Experience and Systematic Literature Review," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    4. Wolfgang Goymann & John C. Wingfield, 2014. "Male-to-female testosterone ratios, dimorphism, and life history—what does it really tell us?," Behavioral Ecology, International Society for Behavioral Ecology, vol. 25(4), pages 685-699.
    5. Alderotti, Giammarco & Rapallini, Chiara & Traverso, Silvio, 2023. "The Big Five personality traits and earnings: A meta-analysis," Journal of Economic Psychology, Elsevier, vol. 94(C).
    6. Ünal, Zehra E. & Kartal, Gamze & Ulusoy, Serra & Ala, Aslı M. & Yilmaz, Munube & Geary, David C., 2023. "Relative contributions of g and basic domain-specific mathematics skills to complex mathematics competencies," Intelligence, Elsevier, vol. 101(C).
    7. Daniele Zago & Maria Eugênia Andrighetto Canozzi & Júlio Otávio Jardim Barcellos, 2020. "Pregnant beef cow’s nutrition and its effects on postnatal weight and carcass quality of their progeny," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-20, August.
    8. Viktoria Maria Baumeister & Leonie Petra Kuen & Maike Bruckes & Gerhard Schewe, 2021. "The Relationship of Work-Related ICT Use With Well-being, Incorporating the Role of Resources and Demands: A Meta-Analysis," SAGE Open, , vol. 11(4), pages 21582440211, November.
    9. Gundula Krack, 2019. "How to make value-based health insurance designs more effective? A systematic review and meta-analysis," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 20(6), pages 841-856, August.
    10. Angélica Pigola & Priscila Rezende Costa, 2022. "In search of understanding about knowledge and learning on innovation performance," Scientometrics, Springer;Akadémiai Kiadó, vol. 127(7), pages 3995-4022, July.
    11. Christopher Snyder & Ran Zhuo, 2018. "Sniff Tests as a Screen in the Publication Process: Throwing out the Wheat with the Chaff," NBER Working Papers 25058, National Bureau of Economic Research, Inc.
    12. Chuang Yuan & Jing Wang & Michael Ying, 2016. "Predictive Value of Carotid Distensibility Coefficient for Cardiovascular Diseases and All-Cause Mortality: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-15, April.
    13. Francisco Javier Blanco-Encomienda & Rocío García-Cantero & María José Latorre-Medina, 2020. "Association between Work-Related Rumination, Work Environment and Employee Well-Being: A Meta-Analytic Study of Main and Moderator Effects," Social Indicators Research: An International and Interdisciplinary Journal for Quality-of-Life Measurement, Springer, vol. 150(3), pages 887-910, August.
    14. Pedro L. Cosio & Manuel Crespo-Posadas & Álvaro Velarde-Sotres & Mireia Pelaez, 2021. "Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 18(5), pages 1-16, March.
    15. Augusteijn, Hilde Elisabeth Maria & van Aert, Robbie Cornelis Maria & van Assen, Marcel A. L. M., 2021. "Posterior Probabilities of Effect Sizes and Heterogeneity in Meta-Analysis: An Intuitive Approach of Dealing with Publication Bias," OSF Preprints avkgj, Center for Open Science.
    16. Sesha Kethineni & Susan Frazier‐Kouassi & Yuki Shigemoto & Wesley Jennings & Stephanie M. Cardwell & Alex R. Piquero & Kimberly Gay & Dayanand Sundaravadivelu, 2021. "PROTOCOL: Effectiveness of parent‐engagement programs to reduce truancy and juvenile delinquency: A systematic review," Campbell Systematic Reviews, John Wiley & Sons, vol. 17(3), September.
    17. Charlotte E. Gill & Jordan Hyatt & Lawrence W. Sherman, 2010. "PROTOCOL: Probation Intensity Effects on Probationers' Criminal Conduct," Campbell Systematic Reviews, John Wiley & Sons, vol. 6(1), pages 1-25.
    18. Ritchwood, Tiarney D. & Ford, Haley & DeCoster, Jamie & Sutton, Marnie & Lochman, John E., 2015. "Risky sexual behavior and substance use among adolescents: A meta-analysis," Children and Youth Services Review, Elsevier, vol. 52(C), pages 74-88.
    19. Georgiou, George K. & Guo, Kan & Naveenkumar, Nithya & Vieira, Ana Paula Alves & Das, J.P., 2020. "PASS theory of intelligence and academic achievement: A meta-analytic review," Intelligence, Elsevier, vol. 79(C).
    20. Jonas Moss & Riccardo De Bin, 2023. "Modelling publication bias and p‐hacking," Biometrics, The International Biometric Society, vol. 79(1), pages 319-331, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0080687. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.