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Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis

Author

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  • Ting-Yan Shi
  • Jing He
  • Li-Xin Qiu
  • Mei-Ling Zhu
  • Meng-Yun Wang
  • Xiao-Yan Zhou
  • Jiali Han
  • Hongpin Yu
  • Rong-Yu Zang
  • Qingyi Wei

Abstract

Background: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. Methodology/Principal Findings: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95% CI = 0.76–1.00, P = 0.049, P = 0.723 for heterogeneity test, I2 = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student’s t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger’s test. Conclusion: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.

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  • Ting-Yan Shi & Jing He & Li-Xin Qiu & Mei-Ling Zhu & Meng-Yun Wang & Xiao-Yan Zhou & Jiali Han & Hongpin Yu & Rong-Yu Zang & Qingyi Wei, 2012. "Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0038606
    DOI: 10.1371/journal.pone.0038606
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    References listed on IDEAS

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    1. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
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    1. Bing-Hu Li & Li-Li Zhang & Bei-Bei Zhang & Yan-Wei Yin & Li-Meng Dai & Yan Pi & Lu Guo & Chang-Yue Gao & Chuan-Qin Fang & Jing-Zhou Wang & Jing-Cheng Li, 2013. "Association between NADPH Oxidase p22phox C242T Polymorphism and Ischemic Cerebrovascular Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    2. Haina Du & Nannan Guo & Bin Shi & Qian Zhang & Zhipeng Chen & Kai Lu & Yongqian Shu & Tao Chen & Lingjun Zhu, 2014. "The Effect of XPD Polymorphisms on Digestive Tract Cancers Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-11, May.

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