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The Effect of XPD Polymorphisms on Digestive Tract Cancers Risk: A Meta-Analysis

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  • Haina Du
  • Nannan Guo
  • Bin Shi
  • Qian Zhang
  • Zhipeng Chen
  • Kai Lu
  • Yongqian Shu
  • Tao Chen
  • Lingjun Zhu

Abstract

Background: The Xeroderma pigmento-sum group D gene (XPD) plays a key role in nucleotide excision repair. Single nucleotide polymorphisms (SNP) located in its functional region may alter DNA repair capacity phenotype and cancer risk. Many studies have demonstrated that XPD polymorphisms are significantly associated with digestive tract cancers risk, but the results are inconsistent. We conducted a comprehensive meta-analysis to assess the association between XPD Lys751Gln polymorphism and digestive tract cancers risk. The digestive tract cancers that our study referred to, includes oral cancer, esophageal cancer, gastric cancer and colorectal cancer. Methods: We searched PubMed and EmBase up to December 31, 2012 to identify eligible studies. A total of 37 case-control studies including 9027 cases and 16072 controls were involved in this meta-analysis. Statistical analyses were performed with Stata software (version 11.0, USA). Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association. Results: The results showed that XPD Lys751Gln polymorphism was associated with the increased risk of digestive tract cancers (homozygote comparison (GlnGln vs. LysLys): OR = 1.12, 95% CI = 1.01–1.24, P = 0.029, P heterogeneity = 0.133). We found no statistical evidence for a significantly increased digestive tract cancers risk in the other genetic models. In the subgroup analysis, we also found the homozygote comparison increased the susceptibility of Asian population (OR = 1.28, 95% CI = 1.01–1.63, P = 0.045, P heterogeneity = 0.287). Stratified by cancer type and source of control, no significantly increased cancer risk was found in these subgroups. Additionally, risk estimates from hospital-based studies and esophageal studies were heterogeneous. Conclusions: Our meta-analysis suggested that the XPD 751Gln/Gln genotype was a low-penetrate risk factor for developing digestive tract cancers, especially in Asian populations.

Suggested Citation

  • Haina Du & Nannan Guo & Bin Shi & Qian Zhang & Zhipeng Chen & Kai Lu & Yongqian Shu & Tao Chen & Lingjun Zhu, 2014. "The Effect of XPD Polymorphisms on Digestive Tract Cancers Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0096301
    DOI: 10.1371/journal.pone.0096301
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    References listed on IDEAS

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    1. Ting-Yan Shi & Jing He & Li-Xin Qiu & Mei-Ling Zhu & Meng-Yun Wang & Xiao-Yan Zhou & Jiali Han & Hongpin Yu & Rong-Yu Zang & Qingyi Wei, 2012. "Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-14, July.
    2. Mei-Ling Zhu & Mengyun Wang & Zhi-Gang Cao & Jing He & Ting-Yan Shi & Kai-Qin Xia & Li-Xin Qiu & Qing-Yi Wei, 2012. "Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.
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    1. Yuning Xie & Yuan Yu & Hongjiao Wu & Hui Gao & Zhenbang Yang & Yi Zhang & Xuemei Zhang, 2021. "XAB2 TagSNP Is Associated with the Risk of Gastric Cancer in Chinese Population: A Case–Control Study," IJERPH, MDPI, vol. 18(4), pages 1-7, February.

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