Identification of a Negative Allosteric Site on Human α4β2 and α3β4 Neuronal Nicotinic Acetylcholine Receptors
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DOI: 10.1371/journal.pone.0024949
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- KatjuS̆a Brejc & Willem J. van Dijk & Remco V. Klaassen & Mascha Schuurmans & John van der Oost & August B. Smit & Titia K. Sixma, 2001. "Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors," Nature, Nature, vol. 411(6835), pages 269-276, May.
- Nuriya Mukhtasimova & Won Yong Lee & Hai-Long Wang & Steven M. Sine, 2009. "Detection and trapping of intermediate states priming nicotinic receptor channel opening," Nature, Nature, vol. 459(7245), pages 451-454, May.
- Xiaolin Cheng & Hailong Wang & Barry Grant & Steven M Sine & J Andrew McCammon, 2006. "Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors," PLOS Computational Biology, Public Library of Science, vol. 2(9), pages 1-12, September.
- Rayjean J. Hung & James D. McKay & Valerie Gaborieau & Paolo Boffetta & Mia Hashibe & David Zaridze & Anush Mukeria & Neonilia Szeszenia-Dabrowska & Jolanta Lissowska & Peter Rudnai & Eleonora Fabiano, 2008. "A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25," Nature, Nature, vol. 452(7187), pages 633-637, April.
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