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A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

Author

Listed:
  • Rayjean J. Hung

    (International Agency for Research on Cancer (IARC)
    School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA)

  • James D. McKay

    (International Agency for Research on Cancer (IARC))

  • Valerie Gaborieau

    (International Agency for Research on Cancer (IARC))

  • Paolo Boffetta

    (International Agency for Research on Cancer (IARC))

  • Mia Hashibe

    (International Agency for Research on Cancer (IARC))

  • David Zaridze

    (Institute of Carcinogenesis, Cancer Research Centre, Moscow 115478, Russia)

  • Anush Mukeria

    (Institute of Carcinogenesis, Cancer Research Centre, Moscow 115478, Russia)

  • Neonilia Szeszenia-Dabrowska

    (Institute of Occupational Medicine)

  • Jolanta Lissowska

    (M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology)

  • Peter Rudnai

    (National Institute of Environmental Health)

  • Eleonora Fabianova

    (Specialized Institute of Hygiene and Epidemiology)

  • Dana Mates

    (Institute of Public Health)

  • Vladimir Bencko

    (Charles University in Prague, First Faculty of Medicine, Institute of Hygiene and Epidemiology)

  • Lenka Foretova

    (Masaryk Memorial Cancer Institute)

  • Vladimir Janout

    (Palacky University)

  • Chu Chen

    (Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA)

  • Gary Goodman

    (Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA)

  • John K. Field

    (Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre)

  • Triantafillos Liloglou

    (Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre)

  • George Xinarianos

    (Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre)

  • Adrian Cassidy

    (Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre)

  • John McLaughlin

    (Cancer Care Ontario, and the Samuel Lunenfeld Research Institute)

  • Geoffrey Liu

    (Princess Margaret Hospital, Ontario Cancer Institute)

  • Steven Narod

    (Women’s College Research Institute)

  • Hans E. Krokan

    (Norwegian University of Science and Technology)

  • Frank Skorpen

    (Norwegian University of Science and Technology)

  • Maiken Bratt Elvestad

    (Norwegian University of Science and Technology)

  • Kristian Hveem

    (Norwegian University of Science and Technology)

  • Lars Vatten

    (Norwegian University of Science and Technology)

  • Jakob Linseisen

    (German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany)

  • Françoise Clavel-Chapelon

    (INSERM ERI20, Institut Gustave Roussy)

  • Paolo Vineis

    (Imperial College
    Institute for Scientific Interchange (ISI))

  • H. Bas Bueno-de-Mesquita

    (Centre for Nutrition and Health, National Institute of Public Health and the Environment)

  • Eiliv Lund

    (Institute of Community Medicine, University of Tromsö)

  • Carmen Martinez

    (Andalusian school of Public Health and Ciber Epidemiology y Salud Publica)

  • Sheila Bingham

    (MRC Centre for Nutrition and Cancer, University of Cambridge)

  • Torgny Rasmuson

    (Oncology, Umea University)

  • Pierre Hainaut

    (International Agency for Research on Cancer (IARC))

  • Elio Riboli

    (Imperial College)

  • Wolfgang Ahrens

    (Epidemiological Methods and Etiologic Research, Bremen Institute for Prevention Research and Social Medicine)

  • Simone Benhamou

    (INSERM U794, Fondation Jean Dausset-CEPH, Paris 75010, France
    CNRS FRE2939, Institute Gustave Roussy)

  • Pagona Lagiou

    (University of Athens School of Medicine, Athens 11527, Greece, Harvard School of Public Health, Boston, Massachusetts 02115, USA)

  • Dimitrios Trichopoulos

    (University of Athens School of Medicine, Athens 11527, Greece, Harvard School of Public Health, Boston, Massachusetts 02115, USA)

  • Ivana Holcátová

    (Institute of Hygiene and Epidemiology)

  • Franco Merletti

    (University of Turin)

  • Kristina Kjaerheim

    (Cancer registry of Norway)

  • Antonio Agudo

    (Institut Català d’Oncologia)

  • Gary Macfarlane

    (University of Aberdeen School of Medicine)

  • Renato Talamini

    (Aviano cancer center)

  • Lorenzo Simonato

    (University of Padua)

  • Ray Lowry

    (University of Newcastle Dental School)

  • David I. Conway

    (University of Glasgow Dental School)

  • Ariana Znaor

    (Croatian National Cancer Registry, National Institute of Public Health)

  • Claire Healy

    (Trinity College School of Dental Science)

  • Diana Zelenika

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Anne Boland

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Marc Delepine

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Mario Foglio

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Doris Lechner

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Fumihiko Matsuda

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Helene Blanche

    (Fondation Jean Dausset-CEPH)

  • Ivo Gut

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France)

  • Simon Heath

    (Fondation Jean Dausset-CEPH)

  • Mark Lathrop

    (Centre National de Genotypage, Institut Genomique, Commissariat à l’énergie Atomique, Evry 91000, France
    Fondation Jean Dausset-CEPH)

  • Paul Brennan

    (International Agency for Research on Cancer (IARC))

Abstract

Where there's smoke... With the advent of large genomic data sets, geneticists can examine at a new level the influence of genes on behaviour. Two groups have conducted genome-wide association studies involving lung cancer, and both find that sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility, although the groups took different paths to this result. Hung et al. suggest that this susceptibility is not related to smoking status or frequency, and show association with a specific amino acid change. Thorgeirsson et al. find that alleles present in a cluster of nicotinic acid receptor genes do not influence whether or not a person smokes, but do affect the number of cigarettes smoked per day, and are therefore also associated with risk of lung cancer and peripheral arterial disease. Either way, the possible potential of nicotinic acetylcholine receptors as drug targets is underlined.

Suggested Citation

  • Rayjean J. Hung & James D. McKay & Valerie Gaborieau & Paolo Boffetta & Mia Hashibe & David Zaridze & Anush Mukeria & Neonilia Szeszenia-Dabrowska & Jolanta Lissowska & Peter Rudnai & Eleonora Fabiano, 2008. "A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25," Nature, Nature, vol. 452(7187), pages 633-637, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7187:d:10.1038_nature06885
    DOI: 10.1038/nature06885
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    Cited by:

    1. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
    2. Julie Routhier & Stéphanie Pons & Mohamed Lamine Freidja & Véronique Dalstein & Jérôme Cutrona & Antoine Jonquet & Nathalie Lalun & Jean-Claude Mérol & Mark Lathrop & Jerry A. Stitzel & Gwenola Kervoa, 2021. "An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Xiao-Ying Wu & Shan-Yu Zhou & Zhong-Zheng Niu & Tao Liu & Chuan-Bo Xie & Wei-Qing Chen, 2015. "CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers," IJERPH, MDPI, vol. 12(4), pages 1-14, April.
    4. Jianxin Shi & Kouya Shiraishi & Jiyeon Choi & Keitaro Matsuo & Tzu-Yu Chen & Juncheng Dai & Rayjean J. Hung & Kexin Chen & Xiao-Ou Shu & Young Tae Kim & Maria Teresa Landi & Dongxin Lin & Wei Zheng & , 2023. "Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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