Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-025-56725-w
Download full text from publisher
References listed on IDEAS
- Jianxin Shi & Kouya Shiraishi & Jiyeon Choi & Keitaro Matsuo & Tzu-Yu Chen & Juncheng Dai & Rayjean J. Hung & Kexin Chen & Xiao-Ou Shu & Young Tae Kim & Maria Teresa Landi & Dongxin Lin & Wei Zheng & , 2023. "Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Rajkumar Dorajoo & Xuling Chang & Resham Lal Gurung & Zheng Li & Ling Wang & Renwei Wang & Kenneth B. Beckman & Jennifer Adams-Haduch & Yiamunaa M & Sylvia Liu & Wee Yang Meah & Kar Seng Sim & Su Chi , 2019. "Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
- Carla Márquez-Luna & Steven Gazal & Po-Ru Loh & Samuel S. Kim & Nicholas Furlotte & Adam Auton & Alkes L. Price, 2021. "Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
- Yi Ding & Kangcheng Hou & Ziqi Xu & Aditya Pimplaskar & Ella Petter & Kristin Boulier & Florian Privé & Bjarni J. Vilhjálmsson & Loes M. Olde Loohuis & Bogdan Pasaniuc, 2023. "Polygenic scoring accuracy varies across the genetic ancestry continuum," Nature, Nature, vol. 618(7966), pages 774-781, June.
- Hui Chen & Zeyang Wang & Lihai Gong & Qixuan Wang & Wenyan Chen & Jia Wang & Xuelian Ma & Ruofan Ding & Xing Li & Xudong Zou & Mireya Plass & Cheng Lian & Ting Ni & Gong-Hong Wei & Wei Li & Lin Deng &, 2024. "A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Rayjean J. Hung & James D. McKay & Valerie Gaborieau & Paolo Boffetta & Mia Hashibe & David Zaridze & Anush Mukeria & Neonilia Szeszenia-Dabrowska & Jolanta Lissowska & Peter Rudnai & Eleonora Fabiano, 2008. "A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25," Nature, Nature, vol. 452(7187), pages 633-637, April.
- Jun Fang & Jinping Jia & Matthew Makowski & Mai Xu & Zhaoming Wang & Tongwu Zhang & Jason W. Hoskins & Jiyeon Choi & Younghun Han & Mingfeng Zhang & Janelle Thomas & Michael Kovacs & Irene Collins & M, 2017. "Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148," Nature Communications, Nature, vol. 8(1), pages 1-17, April.
- Jiacheng Miao & Hanmin Guo & Gefei Song & Zijie Zhao & Lin Hou & Qiongshi Lu, 2023. "Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Jason C. Klein & Aidan Keith & Sarah J. Rice & Colin Shepherd & Vikram Agarwal & John Loughlin & Jay Shendure, 2019. "Functional testing of thousands of osteoarthritis-associated variants for regulatory activity," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
- L. Duncan & H. Shen & B. Gelaye & J. Meijsen & K. Ressler & M. Feldman & R. Peterson & B. Domingue, 2019. "Analysis of polygenic risk score usage and performance in diverse human populations," Nature Communications, Nature, vol. 10(1), pages 1-9, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Jun Wang & Qihui Chen & Gang Chen & Yingxiang Li & Guoshu Kong & Chen Zhu, 2020. "What is creating the height premium? New evidence from a Mendelian randomization analysis in China," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-20, April.
- Carla Márquez-Luna & Steven Gazal & Po-Ru Loh & Samuel S. Kim & Nicholas Furlotte & Adam Auton & Alkes L. Price, 2021. "Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
- Jianxin Shi & Kouya Shiraishi & Jiyeon Choi & Keitaro Matsuo & Tzu-Yu Chen & Juncheng Dai & Rayjean J. Hung & Kexin Chen & Xiao-Ou Shu & Young Tae Kim & Maria Teresa Landi & Dongxin Lin & Wei Zheng & , 2023. "Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Injeong Shim & Hiroyuki Kuwahara & NingNing Chen & Mais O. Hashem & Lama AlAbdi & Mohamed Abouelhoda & Hong-Hee Won & Pradeep Natarajan & Patrick T. Ellinor & Amit V. Khera & Xin Gao & Fowzan S. Alkur, 2023. "Clinical utility of polygenic scores for cardiometabolic disease in Arabs," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- H. Serhat Tetikol & Deniz Turgut & Kubra Narci & Gungor Budak & Ozem Kalay & Elif Arslan & Sinem Demirkaya-Budak & Alexey Dolgoborodov & Duygu Kabakci-Zorlu & Vladimir Semenyuk & Amit Jain & Brandi N., 2022. "Pan-African genome demonstrates how population-specific genome graphs improve high-throughput sequencing data analysis," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Mingxuan Cai & Zhiwei Wang & Jiashun Xiao & Xianghong Hu & Gang Chen & Can Yang, 2023. "XMAP: Cross-population fine-mapping by leveraging genetic diversity and accounting for confounding bias," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Trejo, Sam, 2020. "Exploring Genetic Influences on Birth Weight," SocArXiv 7j59q, Center for Open Science.
- Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
- Kaname Kojima & Shu Tadaka & Fumiki Katsuoka & Gen Tamiya & Masayuki Yamamoto & Kengo Kinoshita, 2020. "A genotype imputation method for de-identified haplotype reference information by using recurrent neural network," PLOS Computational Biology, Public Library of Science, vol. 16(10), pages 1-21, October.
- Rebecca Keener & Surya B. Chhetri & Carla J. Connelly & Margaret A. Taub & Matthew P. Conomos & Joshua Weinstock & Bohan Ni & Benjamin Strober & Stella Aslibekyan & Paul L. Auer & Lucas Barwick & Lewi, 2024. "Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
- Benjamin M. Jacobs & Daniel Stow & Sam Hodgson & Julia Zöllner & Miriam Samuel & Stavroula Kanoni & Saeed Bidi & Klaudia Walter & Claudia Langenberg & Ruth Dobson & Sarah Finer & Caroline Morton & Mon, 2024. "Genetic architecture of routinely acquired blood tests in a British South Asian cohort," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
- Nuzulul Kurniansyah & Matthew O. Goodman & Alyna T. Khan & Jiongming Wang & Elena Feofanova & Joshua C. Bis & Kerri L. Wiggins & Jennifer E. Huffman & Tanika Kelly & Tali Elfassy & Xiuqing Guo & Walte, 2023. "Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
- Ananyo Choudhury & Jean-Tristan Brandenburg & Tinashe Chikowore & Dhriti Sengupta & Palwende Romuald Boua & Nigel J. Crowther & Godfred Agongo & Gershim Asiki & F. Xavier Gómez-Olivé & Isaac Kisiangan, 2022. "Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Julie Routhier & Stéphanie Pons & Mohamed Lamine Freidja & Véronique Dalstein & Jérôme Cutrona & Antoine Jonquet & Nathalie Lalun & Jean-Claude Mérol & Mark Lathrop & Jerry A. Stitzel & Gwenola Kervoa, 2021. "An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
- Atlas Khan & Ning Shang & Jordan G. Nestor & Chunhua Weng & George Hripcsak & Peter C. Harris & Ali G. Gharavi & Krzysztof Kiryluk, 2023. "Polygenic risk alters the penetrance of monogenic kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
- Bryan R. Gorman & Sun-Gou Ji & Michael Francis & Anoop K. Sendamarai & Yunling Shi & Poornima Devineni & Uma Saxena & Elizabeth Partan & Andrea K. DeVito & Jinyoung Byun & Younghun Han & Xiangjun Xiao, 2024. "Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Clara Albiñana & Zhihong Zhu & Andrew J. Schork & Andrés Ingason & Hugues Aschard & Isabell Brikell & Cynthia M. Bulik & Liselotte V. Petersen & Esben Agerbo & Jakob Grove & Merete Nordentoft & David , 2023. "Multi-PGS enhances polygenic prediction by combining 937 polygenic scores," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Erping Long & Jinhu Yin & Ju Hye Shin & Yuyan Li & Bolun Li & Alexander Kane & Harsh Patel & Xinti Sun & Cong Wang & Thong Luong & Jun Xia & Younghun Han & Jinyoung Byun & Tongwu Zhang & Wei Zhao & Ma, 2024. "Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Jingning Zhang & Jianan Zhan & Jin Jin & Cheng Ma & Ruzhang Zhao & Jared O’Connell & Yunxuan Jiang & Bertram L. Koelsch & Haoyu Zhang & Nilanjan Chatterjee, 2024. "An ensemble penalized regression method for multi-ancestry polygenic risk prediction," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Kashi Raj Bhattarai & Robert J. Mobley & Kelly R. Barnett & Daniel C. Ferguson & Baranda S. Hansen & Jonathan D. Diedrich & Brennan P. Bergeron & Satoshi Yoshimura & Wenjian Yang & Kristine R. Crews &, 2024. "Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56725-w. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.