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The Effects of Cognitive Therapy Versus ‘Treatment as Usual’ in Patients with Major Depressive Disorder

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  • Janus Christian Jakobsen
  • Jane Lindschou Hansen
  • Ole Jakob Storebø
  • Erik Simonsen
  • Christian Gluud

Abstract

Background: Major depressive disorder afflicts an estimated 17% of individuals during their lifetimes at tremendous suffering and costs. Cognitive therapy may be an effective treatment option for major depressive disorder, but the effects have only had limited assessment in systematic reviews. Methods/Principal Findings: Cochrane systematic review methodology, with meta-analyses and trial sequential analyses of randomized trials, are comparing the effects of cognitive therapy versus ‘treatment as usual’ for major depressive disorder. To be included the participants had to be older than 17 years with a primary diagnosis of major depressive disorder. Altogether, we included eight trials randomizing a total of 719 participants. All eight trials had high risk of bias. Four trials reported data on the 17-item Hamilton Rating Scale for Depression and four trials reported data on the Beck Depression Inventory. Meta-analysis on the data from the Hamilton Rating Scale for Depression showed that cognitive therapy compared with ‘treatment as usual’ significantly reduced depressive symptoms (mean difference −2.15 (95% confidence interval −3.70 to −0.60; P

Suggested Citation

  • Janus Christian Jakobsen & Jane Lindschou Hansen & Ole Jakob Storebø & Erik Simonsen & Christian Gluud, 2011. "The Effects of Cognitive Therapy Versus ‘Treatment as Usual’ in Patients with Major Depressive Disorder," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0022890
    DOI: 10.1371/journal.pone.0022890
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    References listed on IDEAS

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    1. Irving Kirsch & Brett J Deacon & Tania B Huedo-Medina & Alan Scoboria & Thomas J Moore & Blair T Johnson, 2008. "Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration," PLOS Medicine, Public Library of Science, vol. 5(2), pages 1-9, February.
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    Cited by:

    1. Kotaro Imamura & Norito Kawakami & Toshi A Furukawa & Yutaka Matsuyama & Akihito Shimazu & Rino Umanodan & Sonoko Kawakami & Kiyoto Kasai, 2014. "Effects of an Internet-Based Cognitive Behavioral Therapy (iCBT) Program in Manga Format on Improving Subthreshold Depressive Symptoms among Healthy Workers: A Randomized Controlled Trial," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-13, May.
    2. Tomonari Irie & Kengo Yokomitsu & Yuji Sakano, 2019. "Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-30, September.

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