IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i4p2068-d748060.html
   My bibliography  Save this article

Interaction Effect between Physical Activity and the BDNF Val66Met Polymorphism on Depression in Women from the PISMA-ep Study

Author

Listed:
  • Juan Antonio Zarza-Rebollo

    (Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
    Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain)

  • Esther Molina

    (Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain
    Department of Nursing, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain)

  • Elena López-Isac

    (Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
    Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain)

  • Ana M. Pérez-Gutiérrez

    (Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
    Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain)

  • Blanca Gutiérrez

    (Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain
    Department of Psychiatry, Faculty of Medicine, University of Granada, 18016 Granada, Spain)

  • Jorge A. Cervilla

    (Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain
    Department of Psychiatry, Faculty of Medicine, University of Granada, 18016 Granada, Spain
    Mental Health Service, University Hospital San Cecilio, 18016 Granada, Spain)

  • Margarita Rivera

    (Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
    Institute of Neurosciences, Biomedical Research Centre, University of Granada, 18016 Granada, Spain)

Abstract

The relationship between depression and the Val66Met polymorphism at the brain-derived neurotrophic factor gene ( BDNF ), has been largely studied. It has also been related to physical activity, although the results remain inconclusive. The aim of this study is to investigate the relationship between this polymorphism, depression and physical activity in a thoroughly characterised sample of community-based individuals from the PISMA-ep study. A total of 3123 participants from the PISMA-ep study were genotyped for the BDNF Val66Met polymorphism, of which 209 had depression. Our results are in line with previous studies reporting a protective effect of physical activity on depression, specifically in light intensity. Interestingly, we report a gene-environment interaction effect in which Met allele carriers of the BDNF Val66Met polymorphism who reported more hours of physical activity showed a decreased prevalence of depression. This effect was observed in the total sample (OR = 0.95, 95%CI = 0.90–0.99, p = 0.027) and was strengthened in women (OR = 0.93, 95%CI = 0.87–0.98, p = 0.019). These results highlight the potential role of physical activity as a promising therapeutic strategy for preventing and adjuvant treatment of depression and suggest molecular and genetic particularities of depression between sexes.

Suggested Citation

  • Juan Antonio Zarza-Rebollo & Esther Molina & Elena López-Isac & Ana M. Pérez-Gutiérrez & Blanca Gutiérrez & Jorge A. Cervilla & Margarita Rivera, 2022. "Interaction Effect between Physical Activity and the BDNF Val66Met Polymorphism on Depression in Women from the PISMA-ep Study," IJERPH, MDPI, vol. 19(4), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:2068-:d:748060
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/4/2068/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/4/2068/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Irving Kirsch & Brett J Deacon & Tania B Huedo-Medina & Alan Scoboria & Thomas J Moore & Blair T Johnson, 2008. "Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration," PLOS Medicine, Public Library of Science, vol. 5(2), pages 1-9, February.
    2. Adam Dinoff & Nathan Herrmann & Walter Swardfager & Celina S Liu & Chelsea Sherman & Sarah Chan & Krista L Lanctôt, 2016. "The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-Derived Neurotrophic Factor (BDNF): A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-21, September.
    3. Graffelman, Jan, 2015. "Exploring Diallelic Genetic Markers: The HardyWeinberg Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 64(i03).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Janus Christian Jakobsen & Jane Lindschou Hansen & Erik Simonsen & Christian Gluud, 2011. "The Effect of Interpersonal Psychotherapy and other Psychodynamic Therapies versus ‘Treatment as Usual’ in Patients with Major Depressive Disorder," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-9, April.
    2. Michael A Sugarman & Amy M Loree & Boris B Baltes & Emily R Grekin & Irving Kirsch, 2014. "The Efficacy of Paroxetine and Placebo in Treating Anxiety and Depression: A Meta-Analysis of Change on the Hamilton Rating Scales," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-15, August.
    3. Ad. J. W. van de Gevel & Charles N. Noussair, 2013. "The Nexus between Artificial Intelligence and Economics," SpringerBriefs in Economics, Springer, edition 127, number 978-3-642-33648-5, October.
    4. André Russowsky Brunoni & Mariana Lopes & Ted J Kaptchuk & Felipe Fregni, 2009. "Placebo Response of Non-Pharmacological and Pharmacological Trials in Major Depression: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 4(3), pages 1-10, March.
    5. Weisz, George & Knaapen, Loes, 2009. "Diagnosing and treating premenstrual syndrome in five western nations," Social Science & Medicine, Elsevier, vol. 68(8), pages 1498-1505, April.
    6. Seong Kyu Han & Michelle T. McNulty & Christopher J. Benway & Pei Wen & Anya Greenberg & Ana C. Onuchic-Whitford & Dongkeun Jang & Jason Flannick & Noël P. Burtt & Parker C. Wilson & Benjamin D. Humph, 2023. "Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Lijuan Guo & Zhaowei Kong & Yanjie Zhang, 2019. "Qigong-Based Therapy for Treating Adults with Major Depressive Disorder: A Meta-Analysis of Randomized Controlled Trials," IJERPH, MDPI, vol. 16(5), pages 1-11, March.
    8. Felicity Thomas & Lorraine Hansford & Joseph Ford & Katrina Wyatt & Rosemarie McCabe & Richard Byng, 2018. "Moral narratives and mental health: rethinking understandings of distress and healthcare support in contexts of austerity and welfare reform," Palgrave Communications, Palgrave Macmillan, vol. 4(1), pages 1-8, December.
    9. Giuliano Masiero & Fabrizio Mazzonna & Sandro Steinbach & Olaf Verbeek, 2019. "The effect of local growth in antidepressant consumption on mental health outcomes," IdEP Economic Papers 1902, USI Università della Svizzera italiana.
    10. Giuliano Masiero & Fabrizio Mazzonna & Olaf Verbeek, 2018. "What drives the rise of antidepressant consumption? Evidence from Switzerland," IdEP Economic Papers 1801, USI Università della Svizzera italiana.
    11. Klaus Munkholm & Stephanie Winkelbeiner & Philipp Homan, 2020. "Individual response to antidepressants for depression in adults-a meta-analysis and simulation study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-16, August.
    12. Bütikofer, Aline & Cronin, Christopher J. & Skira, Meghan M., 2020. "Employment effects of healthcare policy: Evidence from the 2007 FDA black box warning on antidepressants," Journal of Health Economics, Elsevier, vol. 73(C).
    13. Lekeisha A. Sumner* & Waguih William IsHak & Jonathan Dang, MD & Brigitte Vanle & Naina Mahtani & Itai Danovitch, 2018. "Psychological Interventions in Inpatient Medical Settings: A Brief Review," International Journal of Healthcare and Medical Sciences, Academic Research Publishing Group, vol. 4(5), pages 73-83, 05-2018.
    14. William Hollingworth & Christopher G. Fawsitt & Padraig Dixon & Larisa Duffy & Ricardo Araya & Tim J. Peters & Howard Thom & Nicky J. Welton & Nicola Wiles & Glyn Lewis, 2020. "Cost-Effectiveness of Sertraline in Primary Care According to Initial Severity and Duration of Depressive Symptoms: Findings from the PANDA RCT," PharmacoEconomics - Open, Springer, vol. 4(3), pages 427-438, September.
    15. Lysleine Alves Deus & Hugo de Luca Corrêa & Rodrigo Vanerson Passos Neves & Andrea Lucena Reis & Fernando Sousa Honorato & Victor Lopes Silva & Michel Kendy Souza & Thaís Branquinho de Araújo & Lucas , 2021. "Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle–Brain–Renal Axi," IJERPH, MDPI, vol. 18(21), pages 1-13, October.
    16. Anna Piotrowska & Halina Gattner & Justyna Adamiak & Sylwia Mętel & Olga Czerwińska-Ledwig & Wanda Pilch & Ewa Sadowska-Krępa & Małgorzata Żychowska & Ivan Uher & Tomasz Pałka, 2022. "Effect of Whole-Body Vibration on Serum Levels of Brain Derived Neurotrophic Factor and Cortisol in Young, Healthy Women," IJERPH, MDPI, vol. 19(23), pages 1-11, December.
    17. Sebastian Hacker & Thomas Reichel & Anne Hecksteden & Christopher Weyh & Kristina Gebhardt & Mark Pfeiffer & Alexander Ferrauti & Michael Kellmann & Tim Meyer & Karsten Krüger, 2021. "Recovery-Stress Response of Blood-Based Biomarkers," IJERPH, MDPI, vol. 18(11), pages 1-12, May.
    18. Bishop, Felicity L. & Jacobson, Eric E. & Shaw, Jessica R. & Kaptchuk, Ted J., 2012. "Scientific tools, fake treatments, or triggers for psychological healing: How clinical trial participants conceptualise placebos," Social Science & Medicine, Elsevier, vol. 74(5), pages 767-774.
    19. Danielle Hen-Shoval & Aron Weller & Abraham Weizman & Gal Shoval, 2022. "Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review," IJERPH, MDPI, vol. 19(1), pages 1-19, January.
    20. Miroslaw Babiarz & Radoslaw Laskowski & Tomasz Grzywacz, 2022. "Effects of Strength Training on BDNF in Healthy Young Adults," IJERPH, MDPI, vol. 19(21), pages 1-14, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:4:p:2068-:d:748060. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.