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Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies

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  • Haiyan Chu
  • Meilin Wang
  • Danni Shi
  • Lan Ma
  • Zhizhong Zhang
  • Na Tong
  • Xinying Huo
  • Wei Wang
  • Dewei Luo
  • Yan Gao
  • Zhengdong Zhang

Abstract

Background: MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. Methodology/Principal Findings: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR = 1.18, 95% CI = 1.03–1.34, P

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  • Haiyan Chu & Meilin Wang & Danni Shi & Lan Ma & Zhizhong Zhang & Na Tong & Xinying Huo & Wei Wang & Dewei Luo & Yan Gao & Zhengdong Zhang, 2011. "Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-6, March.
    • Handle: RePEc:plo:pone00:0018108
    DOI: 10.1371/journal.pone.0018108
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    References listed on IDEAS

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    1. Victor Ambros, 2004. "The functions of animal microRNAs," Nature, Nature, vol. 431(7006), pages 350-355, September.
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    1. Kshitij Srivastava & Anvesha Srivastava, 2012. "Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-1, November.
    2. Ping-Yu Wang & Zong-Hua Gao & Zhong-Hua Jiang & Xin-Xin Li & Bao-Fa Jiang & Shu-Yang Xie, 2013. "The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-7, September.
    3. Zhongxia Wang & Yin Cao & Chunping Jiang & Guang Yang & Junhua Wu & Yitao Ding, 2012. "Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
    4. Jing Guo & Mingjuan Jin & Mingwu Zhang & Kun Chen, 2012. "A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    5. Zhengrong Yuan & Xu Zeng & Dan Yang & Weilu Wang & Zhihua Liu, 2013. "Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    6. Yulan Liu & Hongbo Lei & Jixiang Zhang & Jun Wang & Kui Li & Weiguo Dong, 2015. "Associations between the Genetic Polymorphisms of Osteopontin Promoter and Susceptibility to Cancer in Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.

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