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Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk

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  • Zhengrong Yuan
  • Xu Zeng
  • Dan Yang
  • Weilu Wang
  • Zhihua Liu

Abstract

Background: Emerging evidence suggests that single nucleotide polymorphisms (SNPs) in microRNA-coding genes may participate in the pathogenesis of lung cancer by altering the expression of tumor-related microRNAs. Several studies were investigated in recent years to evaluate the association between hsa-miR-196a2 rs11614913 polymorphism and increased/decreased lung cancer risk. In the present study, we performed a meta-analysis to systematically summarize the possible association. Methodology/Principal Findings: We performed a meta-analysis of 4 case-control studies that included 2219 lung-cancer cases and 2232 cancer-free controls. We evaluated the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In the overall analysis, it was found that the rs11614913 polymorphism significantly elevated the risk of lung cancer (CC versus (vs.) TT OR = 1.26, 95% CI 1.07–1.49, P = 0.007; CC/CT vs. TT: OR = 1.13, 95% CI 0.98–1.29, P = 0.007; C vs. T: OR = 1.12, 95% CI 1.03–1.22, P = 0.008). In the subgroup analysis by ethnicity, statistically significantly increased cancer risk was found among Asians (CC vs. TT: OR = 1.30, 95% CI 1.10–1.54, P = 0.003; CT vs. TT: OR = 1.16, 95% CI 1.01–1.34, P = 0.039; CC vs. CT/TT: OR = 1.21, 95% CI 1.04–1.41, P = 0.012; C vs. T: OR = 1.14, 95% CI 1.05–1.25, P = 0.002). For Europeans, a significant association with lung cancer risk was found in recessive model (CC vs. CT/TT: OR = 0.63, 95% CI 0.40–0.98, P = 0.040). No publication bias was found in this study. Conclusions/Significance: Our meta-analysis suggests that the rs11614913 polymorphism is significant associated with the increased risk of lung cancer, especially in Asians. Besides, the C allele of rs11614913 polymorphism may contribute to increased lung cancer risk.

Suggested Citation

  • Zhengrong Yuan & Xu Zeng & Dan Yang & Weilu Wang & Zhihua Liu, 2013. "Effects of Common Polymorphism rs11614913 in Hsa-miR-196a2 on Lung Cancer Risk," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-8, April.
    • Handle: RePEc:plo:pone00:0061047
    DOI: 10.1371/journal.pone.0061047
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    References listed on IDEAS

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    1. Haiyan Chu & Meilin Wang & Danni Shi & Lan Ma & Zhizhong Zhang & Na Tong & Xinying Huo & Wei Wang & Dewei Luo & Yan Gao & Zhengdong Zhang, 2011. "Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-6, March.
    2. Jing Guo & Mingjuan Jin & Mingwu Zhang & Kun Chen, 2012. "A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-7, January.
    3. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    4. Wei Xu & Jijun Xu & Shifeng Liu & Bo Chen & Xueli Wang & Yan Li & Yun Qian & Weihong Zhao & Jianqing Wu, 2011. "Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-7, May.
    5. Zhongxia Wang & Yin Cao & Chunping Jiang & Guang Yang & Junhua Wu & Yitao Ding, 2012. "Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.
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    1. Xiao Pin Ma & Ting Zhang & Bo Peng & Long Yu & De Ke Jiang, 2013. "Association between microRNA Polymorphisms and Cancer Risk Based on the Findings of 66 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.

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