IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0031615.html
   My bibliography  Save this article

Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans

Author

Listed:
  • Hai Lian
  • Lei Wang
  • Jingmin Zhang

Abstract

Background: Emerging evidence suggests that microRNAs play a critical role in the pathogenesis of breast cancer. Several molecular epidemiological studies were conducted in recent years to evaluate the association between has-miR-146a rs2910164 polymorphism and breast cancer risk in diverse populations. However, the results remain conflicting rather than conclusive. Methodology/Principal findings: We performed a meta-analysis of 6 case-control studies that included 4238 breast-cancer cases and 4469 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed that the rs2910164 polymorphism was not associated with a significantly increased risk of breast cancer in all genetic models (for GC vs GG: OR = 1.00, 95% CI = 0.90−1.09, Pheterpgeneity = 0.364; for CC vs GG: OR = 1.16, 95% CI = 0.98−1.36, Pheterpgeneity = 0.757; for GC+CC vs GG: OR = 1.02, 95% CI = 0.93−1.12, Pheterpgeneity = 0.562; for CC vs GC+GG: OR = 1.10, 95% CI = 0.96−1.26, Pheterpgeneity = 0.441). However, in the stratified analysis by ethnicity, we found the rs2910164 polymorphism was associated with increased breast cancer risk among Europeans in homozygote comparison (CC vs. GG: OR = 1.29, 95%CI = 1.02−1.63, Pheterpgeneity = 0.950, P = 0.032) and recessive model (CC vs. GC+GG: OR = 1.31, 95%CI = 1.05−1.65, Pheterpgeneity = 0.839, P = 0.019). No publication bias was found in the present study. Conclusions/Significance: This meta-analysis suggests, for the first time, that the CC homozygote of rs2910164 may contribute to breast cancer susceptibility in Europeans.

Suggested Citation

  • Hai Lian & Lei Wang & Jingmin Zhang, 2012. "Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-7, February.
    • Handle: RePEc:plo:pone00:0031615
    DOI: 10.1371/journal.pone.0031615
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031615
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031615&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0031615?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Victor Ambros, 2004. "The functions of animal microRNAs," Nature, Nature, vol. 431(7006), pages 350-355, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Man-Tang Qiu & Jing-Wen Hu & Xiang-Xiang Ding & Xin Yang & Zhi Zhang & Rong Yin & Lin Xu, 2012. "Hsa-miR-499 rs3746444 Polymorphism Contributes to Cancer Risk: A Meta-Analysis of 12 Studies," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    2. Kshitij Srivastava & Anvesha Srivastava, 2012. "Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-1, November.
    3. Ping-Yu Wang & Zong-Hua Gao & Zhong-Hua Jiang & Xin-Xin Li & Bao-Fa Jiang & Shu-Yang Xie, 2013. "The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-7, September.
    4. Zhongxia Wang & Yin Cao & Chunping Jiang & Guang Yang & Junhua Wu & Yitao Ding, 2012. "Lack of Association of Two Common Polymorphisms rs2910164 and rs11614913 with Susceptibility to Hepatocellular Carcinoma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(6), pages 1-8, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. José María Galván-Román & Ángel Lancho-Sánchez & Sergio Luquero-Bueno & Lorena Vega-Piris & Jose Curbelo & Marcos Manzaneque-Pradales & Manuel Gómez & Hortensia de la Fuente & Mara Ortega-Gómez & Javi, 2020. "Usefulness of circulating microRNAs miR-146a and miR-16-5p as prognostic biomarkers in community-acquired pneumonia," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-13, October.
    2. Kshitij Srivastava & Anvesha Srivastava, 2012. "Comprehensive Review of Genetic Association Studies and Meta-Analyses on miRNA Polymorphisms and Cancer Risk," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-1, November.
    3. Yanyan Wang & Yujie Zhang & Chi Pan & Feixia Ma & Suzhan Zhang, 2015. "Prediction of Poor Prognosis in Breast Cancer Patients Based on MicroRNA-21 Expression: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.
    4. Charlotte Glinge & Sebastian Clauss & Kim Boddum & Reza Jabbari & Javad Jabbari & Bjarke Risgaard & Philipp Tomsits & Bianca Hildebrand & Stefan Kääb & Reza Wakili & Thomas Jespersen & Jacob Tfelt-Han, 2017. "Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-16, February.
    5. Hossain Ahmed & Beyene Joseph, 2013. "Estimation of weighted log partial area under the ROC curve and its application to MicroRNA expression data," Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 12(6), pages 743-755, December.
    6. Le Thi Truc Linh, 2018. "The Microrna 29 family and its regulation," HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY, vol. 8(1), pages 18-27.
    7. Seyedehsadaf Asfa & Halil Ibrahim Toy & Reza Arshinchi Bonab & George P. Chrousos & Athanasia Pavlopoulou & Styliani A. Geronikolou, 2023. "Soft Tissue Ewing Sarcoma Cell Drug Resistance Revisited: A Systems Biology Approach," IJERPH, MDPI, vol. 20(13), pages 1-17, July.
    8. Li Li & Yunjian Sheng & Lin Lv & Jian Gao, 2013. "The Association between Two MicroRNA Variants (miR-499, miR-149) and Gastrointestinal Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    9. Blanca Elena Castro-Magdonel & Manuela Orjuela & Diana E Alvarez-Suarez & Javier Camacho & Lourdes Cabrera-Muñoz & Stanislaw Sadowinski-Pine & Aurora Medina-Sanson & Citlali Lara-Molina & Daphne Garcí, 2020. "Circulating miRNome detection analysis reveals 537 miRNAS in plasma, 625 in extracellular vesicles and a discriminant plasma signature of 19 miRNAs in children with retinoblastoma from which 14 are al," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-19, April.
    10. Adam Emmer, 2019. "The careers behind and the impact of solo author articles in Nature and Science," Scientometrics, Springer;Akadémiai Kiadó, vol. 120(2), pages 825-840, August.
    11. Junpeng Zhang & Taosheng Xu & Lin Liu & Wu Zhang & Chunwen Zhao & Sijing Li & Jiuyong Li & Nini Rao & Thuc Duy Le, 2020. "LMSM: A modular approach for identifying lncRNA related miRNA sponge modules in breast cancer," PLOS Computational Biology, Public Library of Science, vol. 16(4), pages 1-22, April.
    12. Hisakazu Iwama & Kiyohito Kato & Hitomi Imachi & Koji Murao & Tsutomu Masaki, 2018. "Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-20, May.
    13. Hongbo Shi & Guangde Zhang & Meng Zhou & Liang Cheng & Haixiu Yang & Jing Wang & Jie Sun & Zhenzhen Wang, 2016. "Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-15, February.
    14. Haiyan Chu & Meilin Wang & Danni Shi & Lan Ma & Zhizhong Zhang & Na Tong & Xinying Huo & Wei Wang & Dewei Luo & Yan Gao & Zhengdong Zhang, 2011. "Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-6, March.
    15. Pamela R Matias-Garcia & Rory Wilson & Veronika Mussack & Eva Reischl & Melanie Waldenberger & Christian Gieger & Gabriele Anton & Annette Peters & Andrea Kuehn-Steven, 2020. "Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-19, January.
    16. Xing Chen & Jun Yin & Jia Qu & Li Huang, 2018. "MDHGI: Matrix Decomposition and Heterogeneous Graph Inference for miRNA-disease association prediction," PLOS Computational Biology, Public Library of Science, vol. 14(8), pages 1-24, August.
    17. Thierry Chekouo & Francesco C. Stingo & James D. Doecke & Kim-Anh Do, 2015. "miRNA–target gene regulatory networks: A Bayesian integrative approach to biomarker selection with application to kidney cancer," Biometrics, The International Biometric Society, vol. 71(2), pages 428-438, June.
    18. Xing Chen & Li Huang, 2017. "LRSSLMDA: Laplacian Regularized Sparse Subspace Learning for MiRNA-Disease Association prediction," PLOS Computational Biology, Public Library of Science, vol. 13(12), pages 1-28, December.
    19. Ang Li & Yingwei Deng & Yan Tan & Min Chen, 2021. "A novel miRNA-disease association prediction model using dual random walk with restart and space projection federated method," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-17, June.
    20. Alexander Link & Verena Becker & Ajay Goel & Thomas Wex & Peter Malfertheiner, 2012. "Feasibility of Fecal MicroRNAs as Novel Biomarkers for Pancreatic Cancer," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-9, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0031615. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.