IDEAS home Printed from https://ideas.repec.org/a/plo/pmed00/1003664.html
   My bibliography  Save this article

Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis

Author

Listed:
  • Natan Pereira Gosmann
  • Marianna de Abreu Costa
  • Marianna de Barros Jaeger
  • Luis Souza Motta
  • Júlia Frozi
  • Lucas Spanemberg
  • Gisele Gus Manfro
  • Pim Cuijpers
  • Daniel Samuel Pine
  • Giovanni Abrahão Salum

Abstract

Background: Anxiety, obsessive-compulsive, and stress-related disorders frequently co-occur, and patients often present symptoms of several domains. Treatment involves the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), but data on comparative efficacy and acceptability are lacking. We aimed to compare the efficacy of SSRIs, SNRIs, and placebo in multiple symptom domains in patients with these diagnoses over the lifespan through a 3-level network meta-analysis. Methods and findings: We searched for published and unpublished randomized controlled trials that aimed to assess the efficacy of SSRIs or SNRIs in participants (adults and children) with diagnosis of any anxiety, obsessive-compulsive, or stress-related disorder in MEDLINE, PsycINFO, Embase, and Cochrane Library from inception to 23 April 2015, with an update on 11 November 2020. We supplemented electronic database searches with manual searches for published and unpublished randomized controlled trials registered in publicly accessible clinical trial registries and pharmaceutical companies’ databases. No restriction was made regarding comorbidities with any other mental disorder, participants’ age and sex, blinding of participants and researchers, date of publication, or study language. The primary outcome was the aggregate measure of internalizing symptoms of these disorders. Secondary outcomes included specific symptom domains and treatment discontinuation rate. We estimated standardized mean differences (SMDs) with 3-level network meta-analysis with random slopes by study for medication and assessment instrument. Risk of bias appraisal was performed using the Cochrane Collaboration’s risk of bias tool. This study was registered in PROSPERO (CRD42017069090). We analyzed 469 outcome measures from 135 studies (n = 30,245). Medication (SSRI or SNRI) was more effective than placebo for the aggregate measure of internalizing symptoms (SMD −0.56, 95% CI −0.62 to −0.51, p

Suggested Citation

  • Natan Pereira Gosmann & Marianna de Abreu Costa & Marianna de Barros Jaeger & Luis Souza Motta & Júlia Frozi & Lucas Spanemberg & Gisele Gus Manfro & Pim Cuijpers & Daniel Samuel Pine & Giovanni Abrah, 2021. "Selective serotonin reuptake inhibitors, and serotonin and norepinephrine reuptake inhibitors for anxiety, obsessive-compulsive, and stress disorders: A 3-level network meta-analysis," PLOS Medicine, Public Library of Science, vol. 18(6), pages 1-20, June.
    • Handle: RePEc:plo:pmed00:1003664
    DOI: 10.1371/journal.pmed.1003664
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003664
    Download Restriction: no
    File URL: https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1003664&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pmed.1003664?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    2. Konstantopoulos, Spyros, 2011. "Fixed Effects and Variance Components Estimation in Three-Level Meta-Analysis," IZA Discussion Papers 5678, Institute of Labor Economics (IZA).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sangsuk Yoon & Nathan M. Fong & Angelika Dimoka, 2019. "The robustness of anchoring effects on preferential judgments," Judgment and Decision Making, Society for Judgment and Decision Making, vol. 14(4), pages 470-487, July.
    2. Christopher Hansen & Joern Block & Matthias Neuenkirch, 2020. "Family Firm Performance Over The Business Cycle: A Meta‐Analysis," Journal of Economic Surveys, Wiley Blackwell, vol. 34(3), pages 476-511, July.
    3. Jaskiewicz, Peter & Block, Joern & Wagner, Dominik & Carney, Michael & Hansen, Christopher, 2021. "How do cross-country differences in institutional trust and trust in family explain the mixed performance effects of family management? A meta-analysis," Journal of World Business, Elsevier, vol. 56(5).
    4. repec:cup:judgdm:v:14:y:2019:i:4:p:470-487 is not listed on IDEAS
    5. John Protzko & Jon Krosnick & Leif Nelson & Brian A. Nosek & Jordan Axt & Matt Berent & Nicholas Buttrick & Matthew DeBell & Charles R. Ebersole & Sebastian Lundmark & Bo MacInnis & Michael O’Donnell , 2024. "RETRACTED ARTICLE: High replicability of newly discovered social-behavioural findings is achievable," Nature Human Behaviour, Nature, vol. 8(2), pages 311-319, February.
    6. Johannes Knoll & Jörg Matthes, 2017. "The effectiveness of celebrity endorsements: a meta-analysis," Journal of the Academy of Marketing Science, Springer, vol. 45(1), pages 55-75, January.
    7. Schubert, Anna-Lena, 2019. "A meta-analysis of the worst performance rule," Intelligence, Elsevier, vol. 73(C), pages 88-100.
    8. Boris Forthmann & Karin Kaczykowski & Mathias Benedek & Heinz Holling, 2023. "The Manic Idea Creator? A Review and Meta-Analysis of the Relationship between Bipolar Disorder and Creative Cognitive Potential," IJERPH, MDPI, vol. 20(13), pages 1-39, June.
    9. Cinar, Ozan & Nakagawa, Shinichi & Viechtbauer, Wolfgang, 2020. "Phylogenetic multilevel meta-analysis: A simulation study on the importance of modeling the phylogeny," EcoEvoRxiv su4zv, Center for Open Science.
    10. Neda Nasrollahi & Tim Jowett & Liana Machado, 2022. "Emotional information processing in young and older adults: meta-analysis reveals faces elicit distinct biases," European Journal of Ageing, Springer, vol. 19(3), pages 369-379, September.
    11. Pellón-Elexpuru, Inés & Van Dijk, Rianne & Van der Valk, Inge & Martínez-Pampliega, Ana & Molleda, Asier & Cormenzana, Susana, 2024. "Divorce and physical health: A three-level meta-analysis," Social Science & Medicine, Elsevier, vol. 352(C).
    12. Colagrossi, Marco & Rossignoli, Domenico & Maggioni, Mario A., 2020. "Does democracy cause growth? A meta-analysis (of 2000 regressions)," European Journal of Political Economy, Elsevier, vol. 61(C).
    13. Thomas Rockstuhl & Robert Eisenberger & Lynn M. Shore & James N. Kurtessis & Michael T. Ford & Louis C. Buffardi & Salar Mesdaghinia, 2020. "Perceived organizational support (POS) across 54 nations: A cross-cultural meta-analysis of POS effects," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 51(6), pages 933-962, August.
    14. Schaerer, Michael & du Plessis, Christilene & Nguyen, My Hoang Bao & van Aert, Robbie C.M. & Tiokhin, Leo & Lakens, Daniël & Giulia Clemente, Elena & Pfeiffer, Thomas & Dreber, Anna & Johannesson, Mag, 2023. "On the trajectory of discrimination: A meta-analysis and forecasting survey capturing 44 years of field experiments on gender and hiring decisions," Organizational Behavior and Human Decision Processes, Elsevier, vol. 179(C).
    15. Babin, Barry J. & Herrmann, Jean-Luc & Kacha, Mathieu & Babin, Laurie A., 2021. "The effectiveness of brand placements: A meta-analytic synthesis," International Journal of Research in Marketing, Elsevier, vol. 38(4), pages 1017-1033.
    16. François A. Carrillat & Renaud Legoux & Allègre L. Hadida, 2018. "Debates and assumptions about motion picture performance: a meta-analysis," Journal of the Academy of Marketing Science, Springer, vol. 46(2), pages 273-299, March.
    17. Jannis Kraiss & Kleinjan Redelinghuys & Laura. A. Weiss, 2022. "The effects of psychological interventions on well-being measured with the Mental Health Continuum: a meta-analysis," Journal of Happiness Studies, Springer, vol. 23(7), pages 3655-3689, October.
    18. Scharfen, Jana & Peters, Judith Marie & Holling, Heinz, 2018. "Retest effects in cognitive ability tests: A meta-analysis," Intelligence, Elsevier, vol. 67(C), pages 44-66.
    19. Thomas Rockstuhl & Dongyuan Wu & James H. Dulebohn & Chenwei Liao & Julia E. Hoch, 2023. "Cultural congruence or compensation? A meta-analytic test of transformational and transactional leadership effects across cultures," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 54(3), pages 476-504, April.
    20. Marco Colagrossi & Domenico Rossignoli & Mario A. Maggioni, 2017. "Does democracy cause growth? A meta-analysis perspective," DISEIS - Quaderni del Dipartimento di Economia internazionale, delle istituzioni e dello sviluppo dis1703, Università Cattolica del Sacro Cuore, Dipartimento di Economia internazionale, delle istituzioni e dello sviluppo (DISEIS).
    21. Whitney S Beck & Ed K Hall, 2018. "Confounding factors in algal phosphorus limitation experiments," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-19, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pmed00:1003664. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosmedicine (email available below). General contact details of provider: https://journals.plos.org/plosmedicine/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.