IDEAS home Printed from https://ideas.repec.org/a/oup/geronb/v78y2023i10p1707-1716..html
   My bibliography  Save this article

Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality

Author

Listed:
  • Eric T Klopack
  • Jessica Kelley

Abstract

ObjectivesSocial stress has been shown to affect immune functioning. Past research has found that chronic social stress and latent viral infections accelerate immune aging, leading to chronic disease morbidity and mortality. Chronic stress may also reactivate latent viral infections, like cytomegalovirus (CMV), accelerating the aging of the immune system.MethodUtilizing panel survey data from 8,995 U.S. adults aged 56 or older from the Health and Retirement Study, this study investigates whether chronic stress interacts with CMV positivity to drive aging of the immune system, multimorbidity, and mortality.ResultsResults of moderated mediation analysis indicate that the effect of CMV positivity on morbidity and mortality as mediated by immune aging indicators is amplified by chronic stress.DiscussionThese findings suggest that immune aging is a biological pathway underlying the stress process and help explain past findings in the literature on stress and health.

Suggested Citation

  • Eric T Klopack & Jessica Kelley, 2023. "Chronic Stress and Latent Virus Reactivation: Effects on Immune Aging, Chronic Disease Morbidity, and Mortality," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 78(10), pages 1707-1716.
  • Handle: RePEc:oup:geronb:v:78:y:2023:i:10:p:1707-1716.
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1093/geronb/gbad087
    Download Restriction: Access to full text is restricted to subscribers.
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Simons, Ronald L. & Lei, Man-Kit & Klopack, Eric & Beach, Steven R.H. & Gibbons, Frederick X. & Philibert, Robert A., 2021. "The effects of social adversity, discrimination, and health risk behaviors on the accelerated aging of African Americans: Further support for the weathering hypothesis," Social Science & Medicine, Elsevier, vol. 282(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lei, Man-Kit & Berg, Mark T. & Simons, Ronald L. & Beach, Steven R.H., 2022. "Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults," Social Science & Medicine, Elsevier, vol. 293(C).
    2. Jenkins, August I.C. & Surachman, Agus & Armendariz, Marina, 2024. "Where I'm Livin’ and How I'm Feelin’: Associations among community stress, gender, and mental-emotional health among Black Americans," Social Science & Medicine, Elsevier, vol. 348(C).
    3. Berg, Mark T. & Rogers, Ethan M. & Riley, Kendall & Lei, Man-Kit & Simons, Ronald L., 2022. "Incarceration exposure and epigenetic aging in neighborhood context," Social Science & Medicine, Elsevier, vol. 310(C).
    4. Jackson, Pamela & Spector, Antoinette L. & Strath, Larissa J. & Antoine, Lisa H. & Li, Peng & Goodin, Burel R. & Hidalgo, Bertha A. & Kempf, Mirjam-Colette & Gonzalez, Cesar E. & Jones, Alana C. & Fos, 2023. "Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain," Social Science & Medicine, Elsevier, vol. 331(C).
    5. Sadler, Richard C. & Wojciechowski, Thomas W. & Buchalski, Zachary & Smart, Mieka & Mulheron, Megan & Todem, David, 2022. "Validating a geospatial healthfulness index with self-reported chronic disease and health outcomes," Social Science & Medicine, Elsevier, vol. 311(C).
    6. Han Liu & Tse-Chuan Yang, 2022. "Examining the Reciprocity Between Perceived Discrimination and Health: A Longitudinal Perspective," Population Research and Policy Review, Springer;Southern Demographic Association (SDA), vol. 41(4), pages 1757-1777, August.
    7. Simons, Ronald L. & Ong, Mei Ling & Lei, Man-Kit & Klopach, Eric & Berg, Mark & Zhang, Yue & Philibert, Robert & Gibbons, Frederick X. & Beach, Steven R.H., 2022. "Shifts in lifestyle and socioeconomic circumstances predict change—for better or worse—in speed of epigenetic aging: A study of middle-aged black women," Social Science & Medicine, Elsevier, vol. 307(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:oup:geronb:v:78:y:2023:i:10:p:1707-1716.. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Oxford University Press (email available below). General contact details of provider: https://academic.oup.com/psychsocgerontology .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.