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Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults

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  • Lei, Man-Kit
  • Berg, Mark T.
  • Simons, Ronald L.
  • Beach, Steven R.H.

Abstract

Research on the social determinants of health has suggested that neighborhood disadvantage may undermine healthy aging and is particularly relevant for understanding health disparities. Recently, this work has examined deoxyribonucleic acid methylation (DNAm)-based measures of biological aging to understand the risk factors for morbidity and mortality. However, it is unknown whether neighborhood disadvantage is related to different indices of DNAm-based aging among Black Americans and whether such neighborhood effects vary as a function of age or gender.

Suggested Citation

  • Lei, Man-Kit & Berg, Mark T. & Simons, Ronald L. & Beach, Steven R.H., 2022. "Neighborhood structural disadvantage and biological aging in a sample of Black middle age and young adults," Social Science & Medicine, Elsevier, vol. 293(C).
    • Handle: RePEc:eee:socmed:v:293:y:2022:i:c:s0277953621009862
    DOI: 10.1016/j.socscimed.2021.114654
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    References listed on IDEAS

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    1. Lei, Man-Kit & Beach, Steven R.H. & Simons, Ronald L. & Philibert, Robert A., 2015. "Neighborhood crime and depressive symptoms among African American women: Genetic moderation and epigenetic mediation of effects," Social Science & Medicine, Elsevier, vol. 146(C), pages 120-128.
    2. Simons, Ronald L. & Lei, Man-Kit & Klopack, Eric & Beach, Steven R.H. & Gibbons, Frederick X. & Philibert, Robert A., 2021. "The effects of social adversity, discrimination, and health risk behaviors on the accelerated aging of African Americans: Further support for the weathering hypothesis," Social Science & Medicine, Elsevier, vol. 282(C).
    3. Geronimus, A.T., 2013. "Deep integration: Letting the epigenome out of the bottle without losing sight of the structural origins of population health," American Journal of Public Health, American Public Health Association, vol. 103(SUPPL.1), pages 56-63.
    4. Man-Kit Lei & Ronald L Simons & Steven R H Beach & Robert A Philibert & Philippa Clarke, 2019. "Neighborhood Disadvantage and Biological Aging: Using Marginal Structural Models to Assess the Link Between Neighborhood Census Variables and Epigenetic Aging," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 74(7), pages 50-59.
    5. Singh, G.K., 2003. "Area Deprivation and Widening Inequalities in US Mortality, 1969-1998," American Journal of Public Health, American Public Health Association, vol. 93(7), pages 1137-1143.
    6. Evans, Linnea & Engelman, Michal & Mikulas, Alex & Malecki, Kristen, 2021. "How are social determinants of health integrated into epigenetic research? A systematic review," Social Science & Medicine, Elsevier, vol. 273(C).
    7. Austin Nichols & Mark E Schaffer, 2007. "Clustered standard errors in Stata," United Kingdom Stata Users' Group Meetings 2007 07, Stata Users Group.
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    1. Berg, Mark T. & Rogers, Ethan M. & Riley, Kendall & Lei, Man-Kit & Simons, Ronald L., 2022. "Incarceration exposure and epigenetic aging in neighborhood context," Social Science & Medicine, Elsevier, vol. 310(C).
    2. Jackson, Pamela & Spector, Antoinette L. & Strath, Larissa J. & Antoine, Lisa H. & Li, Peng & Goodin, Burel R. & Hidalgo, Bertha A. & Kempf, Mirjam-Colette & Gonzalez, Cesar E. & Jones, Alana C. & Fos, 2023. "Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain," Social Science & Medicine, Elsevier, vol. 331(C).

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