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Anatomy and function of an excitatory network in the visual cortex

Author

Listed:
  • Wei-Chung Allen Lee

    (Harvard Medical School)

  • Vincent Bonin

    (Harvard Medical School
    Neuro-Electronics Research Flanders, a research initiative by imec, Vlaams Instituut voor Biotechnologie (VIB) and Katholieke Universiteit (KU))

  • Michael Reed

    (Harvard Medical School)

  • Brett J. Graham

    (Harvard Medical School)

  • Greg Hood

    (Biomedical Applications Group, Pittsburgh Supercomputing Center, Carnegie Mellon University)

  • Katie Glattfelder

    (Allen Institute for Brain Science)

  • R. Clay Reid

    (Harvard Medical School
    Allen Institute for Brain Science)

Abstract

Two-photon calcium imaging and electron microscopy were used to explore the relationship between structure and function in mouse primary visual cortex, showing that layer 2/3 neurons are connected in subnetworks, that pyramidal neurons with similar orientation selectivity preferentially form synapses with each other, and that neurons with similar orientation tuning form larger synapses; this study exemplifies functional connectomics as a powerful method for studying the organizational logic of cortical networks.

Suggested Citation

  • Wei-Chung Allen Lee & Vincent Bonin & Michael Reed & Brett J. Graham & Greg Hood & Katie Glattfelder & R. Clay Reid, 2016. "Anatomy and function of an excitatory network in the visual cortex," Nature, Nature, vol. 532(7599), pages 370-374, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7599:d:10.1038_nature17192
    DOI: 10.1038/nature17192
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    Cited by:

    1. Jochen Meyer & Kwanha Yu & Estefania Luna-Figueroa & Benjamin Deneen & Jeffrey Noebels, 2024. "Glioblastoma disrupts cortical network activity at multiple spatial and temporal scales," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Bettina Voelcker & Ravi Pancholi & Simon Peron, 2022. "Transformation of primary sensory cortical representations from layer 4 to layer 2," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Gabriel Koch Ocker & Krešimir Josić & Eric Shea-Brown & Michael A Buice, 2017. "Linking structure and activity in nonlinear spiking networks," PLOS Computational Biology, Public Library of Science, vol. 13(6), pages 1-47, June.
    4. Andrew Jo & Sercan Deniz & Suraj Cherian & Jian Xu & Daiki Futagi & Steven H. DeVries & Yongling Zhu, 2023. "Modular interneuron circuits control motion sensitivity in the mouse retina," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Sean R Bittner & Ryan C Williamson & Adam C Snyder & Ashok Litwin-Kumar & Brent Doiron & Steven M Chase & Matthew A Smith & Byron M Yu, 2017. "Population activity structure of excitatory and inhibitory neurons," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-27, August.
    6. Stefano Recanatesi & Gabriel Koch Ocker & Michael A Buice & Eric Shea-Brown, 2019. "Dimensionality in recurrent spiking networks: Global trends in activity and local origins in connectivity," PLOS Computational Biology, Public Library of Science, vol. 15(7), pages 1-29, July.
    7. Zhou, Xinjia & Zhang, Yan & Gu, Tianyi & Zheng, Muhua & Xu, Kesheng, 2024. "Mixed synaptic modulation and inhibitory plasticity perform complementary roles in metastable transitions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 635(C).
    8. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    9. Carles Bosch & Tobias Ackels & Alexandra Pacureanu & Yuxin Zhang & Christopher J. Peddie & Manuel Berning & Norman Rzepka & Marie-Christine Zdora & Isabell Whiteley & Malte Storm & Anne Bonnin & Chris, 2022. "Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. Zhihao Zheng & Christopher S. Own & Adrian A. Wanner & Randal A. Koene & Eric W. Hammerschmith & William M. Silversmith & Nico Kemnitz & Ran Lu & David W. Tank & H. Sebastian Seung, 2024. "Fast imaging of millimeter-scale areas with beam deflection transmission electron microscopy," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    11. Valmir C. Barbosa, 2017. "Information Integration from Distributed Threshold-Based Interactions," Complexity, Hindawi, vol. 2017, pages 1-14, January.
    12. Hang Zhou & Guo-Qiang Bi & Guosong Liu, 2024. "Intracellular magnesium optimizes transmission efficiency and plasticity of hippocampal synapses by reconfiguring their connectivity," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    13. Lloyd E. Russell & Mehmet Fişek & Zidan Yang & Lynn Pei Tan & Adam M. Packer & Henry W. P. Dalgleish & Selmaan N. Chettih & Christopher D. Harvey & Michael Häusser, 2024. "The influence of cortical activity on perception depends on behavioral state and sensory context," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    14. Bartul Mimica & Tuçe Tombaz & Claudia Battistin & Jingyi Guo Fuglstad & Benjamin A. Dunn & Jonathan R. Whitlock, 2023. "Behavioral decomposition reveals rich encoding structure employed across neocortex in rats," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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