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Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

Author

Listed:
  • Eric J. Steen

    (Joint BioEnergy Institute,
    Synthetic Biology Engineering Research Center, 5885 Hollis Avenue, Emeryville, California 94608, USA
    Departmient of Bioengineering,)

  • Yisheng Kang

    (Joint BioEnergy Institute,
    QB3 Institute,)

  • Gregory Bokinsky

    (Joint BioEnergy Institute,
    QB3 Institute,)

  • Zhihao Hu

    (LS9, Inc., 100 Kimball Way, South San Francisco, California 94080, USA)

  • Andreas Schirmer

    (LS9, Inc., 100 Kimball Way, South San Francisco, California 94080, USA)

  • Amy McClure

    (LS9, Inc., 100 Kimball Way, South San Francisco, California 94080, USA)

  • Stephen B. del Cardayre

    (LS9, Inc., 100 Kimball Way, South San Francisco, California 94080, USA)

  • Jay D. Keasling

    (Joint BioEnergy Institute,
    Synthetic Biology Engineering Research Center, 5885 Hollis Avenue, Emeryville, California 94608, USA
    Departmient of Bioengineering,
    QB3 Institute,)

Abstract

Making more of biomass Plant and animal oils are the raw materials for the manufacture of many biofuels, surfactants, solvents and lubricants. The growing demand and limited supply of these oils is resulting in competition with food, rising prices and environmental concerns associated with their production. A sustainable alternative is to produce these products directly from abundant and cost-effective renewable resources by fermentation. Jay Keasling and colleagues have developed a promising way of doing just that. They engineer Escherichia coli bacteria to produce more complex biofuels — fatty esters and fatty alcohols — direct from simple sugars. They go on to further engineer the E. coli to secrete hemi-cellulases, so that the bacteria can produce these potential biofuels direct from hemicellulose, a major component of plant-derived biomass.

Suggested Citation

  • Eric J. Steen & Yisheng Kang & Gregory Bokinsky & Zhihao Hu & Andreas Schirmer & Amy McClure & Stephen B. del Cardayre & Jay D. Keasling, 2010. "Microbial production of fatty-acid-derived fuels and chemicals from plant biomass," Nature, Nature, vol. 463(7280), pages 559-562, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7280:d:10.1038_nature08721
    DOI: 10.1038/nature08721
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    Cited by:

    1. Srirangan, Kajan & Akawi, Lamees & Moo-Young, Murray & Chou, C. Perry, 2012. "Towards sustainable production of clean energy carriers from biomass resources," Applied Energy, Elsevier, vol. 100(C), pages 172-186.
    2. Yang, Jianming & Li, Zhengfeng & Guo, Lizhong & Du, Juan & Bae, Hyeun-Jong, 2016. "Biosynthesis of β-caryophyllene, a novel terpene-based high-density biofuel precursor, using engineered Escherichia coli," Renewable Energy, Elsevier, vol. 99(C), pages 216-223.
    3. Lim, Jackson Hwa Keen & Gan, Yong Yang & Ong, Hwai Chyuan & Lau, Beng Fye & Chen, Wei-Hsin & Chong, Cheng Tung & Ling, Tau Chuan & Klemeš, Jiří Jaromír, 2021. "Utilization of microalgae for bio-jet fuel production in the aviation sector: Challenges and perspective," Renewable and Sustainable Energy Reviews, Elsevier, vol. 149(C).
    4. Mhatre, Apurv & Kalscheur, Bethany & Mckeown, Haley & Bhakta, Karan & Sarnaik, Aditya P. & Flores, Andrew & Nielsen, David R. & Wang, Xuan & Soundappan, Thiagarajan & Varman, Arul M., 2022. "Consolidated bioprocessing of hemicellulose to fuels and chemicals through an engineered Bacillus subtilis-Escherichia coli consortium," Renewable Energy, Elsevier, vol. 193(C), pages 288-298.
    5. Fernand, Francois & Israel, Alvaro & Skjermo, Jorunn & Wichard, Thomas & Timmermans, Klaas R. & Golberg, Alexander, 2017. "Offshore macroalgae biomass for bioenergy production: Environmental aspects, technological achievements and challenges," Renewable and Sustainable Energy Reviews, Elsevier, vol. 75(C), pages 35-45.
    6. Graham Rockwell & Nicholas J Guido & George M Church, 2013. "Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective," PLOS Computational Biology, Public Library of Science, vol. 9(1), pages 1-15, January.
    7. Bhatia, Shashi Kant & Bhatia, Ravi Kant & Yang, Yung-Hun, 2017. "An overview of microdiesel — A sustainable future source of renewable energy," Renewable and Sustainable Energy Reviews, Elsevier, vol. 79(C), pages 1078-1090.
    8. Li, Mantian & Chen, Jinyi & Huang, Youjie & Li, Meichen & Lin, Xiaocheng & Qiu, Ting, 2020. "Reusable and efficient heterogeneous catalysts for biodiesel production from free fatty acids and oils: Self-solidifying hybrid ionic liquids," Energy, Elsevier, vol. 211(C).
    9. Sadhukhan, Jhuma & Lloyd, Jon R. & Scott, Keith & Premier, Giuliano C. & Yu, Eileen H. & Curtis, Tom & Head, Ian M., 2016. "A critical review of integration analysis of microbial electrosynthesis (MES) systems with waste biorefineries for the production of biofuel and chemical from reuse of CO2," Renewable and Sustainable Energy Reviews, Elsevier, vol. 56(C), pages 116-132.
    10. Bwapwa, Joseph K. & Anandraj, Akash & Trois, Cristina, 2017. "Possibilities for conversion of microalgae oil into aviation fuel: A review," Renewable and Sustainable Energy Reviews, Elsevier, vol. 80(C), pages 1345-1354.
    11. Oncel, Suphi S., 2013. "Microalgae for a macroenergy world," Renewable and Sustainable Energy Reviews, Elsevier, vol. 26(C), pages 241-264.
    12. Chen, Hong-Ge & Zhang, Y.-H. Percival, 2015. "New biorefineries and sustainable agriculture: Increased food, biofuels, and ecosystem security," Renewable and Sustainable Energy Reviews, Elsevier, vol. 47(C), pages 117-132.
    13. Valle-Rodríguez, Juan Octavio & Shi, Shuobo & Siewers, Verena & Nielsen, Jens, 2014. "Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid ethyl esters, an advanced biofuel, by eliminating non-essential fatty acid utilization pathways," Applied Energy, Elsevier, vol. 115(C), pages 226-232.
    14. Zhaoshou Wang & Xin Wu & Jianghai Peng & Yidan Hu & Baishan Fang & Shiyang Huang, 2014. "Artificially Constructed Quorum-Sensing Circuits Are Used for Subtle Control of Bacterial Population Density," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-7, August.
    15. Das, Manali & Patra, Pradipta & Ghosh, Amit, 2020. "Metabolic engineering for enhancing microbial biosynthesis of advanced biofuels," Renewable and Sustainable Energy Reviews, Elsevier, vol. 119(C).
    16. Wang, Wei-Cheng & Tao, Ling, 2016. "Bio-jet fuel conversion technologies," Renewable and Sustainable Energy Reviews, Elsevier, vol. 53(C), pages 801-822.

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