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An excitable gene regulatory circuit induces transient cellular differentiation

Author

Listed:
  • Gürol M. Süel

    (California Institute of Technology)

  • Jordi Garcia-Ojalvo

    (Universitat Politècnica de Catalunya)

  • Louisa M. Liberman

    (California Institute of Technology)

  • Michael B. Elowitz

    (California Institute of Technology)

Abstract

Time-lapse imaging is used to follow the activity of several promoters that regulate competence genes in Bacillus subtilis, and the data used to develop a mathematical model of the gene circuitry — revealing that excitable dynamics underlies the positive and negative feedback loops that regulate entry into, and exit from, competence in an individual cell.

Suggested Citation

  • Gürol M. Süel & Jordi Garcia-Ojalvo & Louisa M. Liberman & Michael B. Elowitz, 2006. "An excitable gene regulatory circuit induces transient cellular differentiation," Nature, Nature, vol. 440(7083), pages 545-550, March.
    • Handle: RePEc:nat:nature:v:440:y:2006:i:7083:d:10.1038_nature04588
    DOI: 10.1038/nature04588
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    Citations

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    Cited by:

    1. Matthieu Wyart & David Botstein & Ned S Wingreen, 2010. "Evaluating Gene Expression Dynamics Using Pairwise RNA FISH Data," PLOS Computational Biology, Public Library of Science, vol. 6(11), pages 1-14, November.
    2. Kazunari Mouri & Yasushi Sako, 2013. "Optimality Conditions for Cell-Fate Heterogeneity That Maximize the Effects of Growth Factors in PC12 Cells," PLOS Computational Biology, Public Library of Science, vol. 9(11), pages 1-15, November.
    3. Ruoyu Luo & Lin Ye & Chenyang Tao & Kankan Wang, 2013. "Simulation of E. coli Gene Regulation including Overlapping Cell Cycles, Growth, Division, Time Delays and Noise," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-10, April.
    4. Zhao, Na & Liu, Haihong & Yan, Fang, 2020. "Oscillation dynamics of MeKS core module containing positive and negative feedback loops with time delay," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 538(C).
    5. Margaritis Voliotis & Philipp Thomas & Ramon Grima & Clive G Bowsher, 2016. "Stochastic Simulation of Biomolecular Networks in Dynamic Environments," PLOS Computational Biology, Public Library of Science, vol. 12(6), pages 1-18, June.
    6. Yu, Haiyan & Liu, Quansheng & Bi, Yuanhong, 2023. "Lévy noise-induced phase transition in p53 gene regulatory network near bifurcation points," Chaos, Solitons & Fractals, Elsevier, vol. 166(C).
    7. Sandra H Dandach & Mustafa Khammash, 2010. "Analysis of Stochastic Strategies in Bacterial Competence: A Master Equation Approach," PLOS Computational Biology, Public Library of Science, vol. 6(11), pages 1-11, November.
    8. Greg J Stephens & Bethany Johnson-Kerner & William Bialek & William S Ryu, 2008. "Dimensionality and Dynamics in the Behavior of C. elegans," PLOS Computational Biology, Public Library of Science, vol. 4(4), pages 1-10, April.
    9. Miles Miller & Marc Hafner & Eduardo Sontag & Noah Davidsohn & Sairam Subramanian & Priscilla E M Purnick & Douglas Lauffenburger & Ron Weiss, 2012. "Modular Design of Artificial Tissue Homeostasis: Robust Control through Synthetic Cellular Heterogeneity," PLOS Computational Biology, Public Library of Science, vol. 8(7), pages 1-18, July.
    10. Payne, Joshua L., 2016. "No tradeoff between versatility and robustness in gene circuit motifs," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 449(C), pages 192-199.
    11. Karin Münch & Richard Münch & Rebekka Biedendieck & Dieter Jahn & Johannes Müller, 2019. "Evolutionary model for the unequal segregation of high copy plasmids," PLOS Computational Biology, Public Library of Science, vol. 15(3), pages 1-17, March.
    12. Benjamin B Kaufmann & Qiong Yang & Jerome T Mettetal & Alexander van Oudenaarden, 2007. "Heritable Stochastic Switching Revealed by Single-Cell Genealogy," PLOS Biology, Public Library of Science, vol. 5(9), pages 1-8, September.
    13. Cabrera Fernández, Juan Luis & Herrera-Almarza, Gioconda C. & Gutiérrez M., Esther D., 2018. "Chromosome progression and mitotic times behavior are mimicked by an stochastic unstable dynamics," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 512(C), pages 1121-1127.
    14. Song, Yi & Xu, Wei, 2021. "Asymmetric Lévy noise changed stability in a gene transcriptional regulatory system," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    15. Jiegen Wu & Baoqiang Chen & Yadi Liu & Liang Ma & Wen Huang & Yihan Lin, 2022. "Modulating gene regulation function by chemically controlled transcription factor clustering," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    16. Chen, Xiaoli & Wu, Fengyan & Duan, Jinqiao & Kurths, Jürgen & Li, Xiaofan, 2019. "Most probable dynamics of a genetic regulatory network under stable Lévy noise," Applied Mathematics and Computation, Elsevier, vol. 348(C), pages 425-436.

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