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Membrane curvature and mechanisms of dynamic cell membrane remodelling

Author

Listed:
  • Harvey T. McMahon

    (MRC Laboratory of Molecular Biology)

  • Jennifer L. Gallop

    (MRC Laboratory of Molecular Biology)

Abstract

Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking. Curvature can be dynamically modulated by changes in lipid composition, the oligomerization of curvature scaffolding proteins and the reversible insertion of protein regions that act like wedges in membranes. There is an interplay between curvature-generating and curvature-sensing proteins during vesicle budding. This is seen during vesicle budding and in the formation of microenvironments. On a larger scale, membrane curvature is a prime player in growth, division and movement.

Suggested Citation

  • Harvey T. McMahon & Jennifer L. Gallop, 2005. "Membrane curvature and mechanisms of dynamic cell membrane remodelling," Nature, Nature, vol. 438(7068), pages 590-596, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7068:d:10.1038_nature04396
    DOI: 10.1038/nature04396
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    Cited by:

    1. Wonchul Shin & Ben Zucker & Nidhi Kundu & Sung Hoon Lee & Bo Shi & Chung Yu Chan & Xiaoli Guo & Jonathan T. Harrison & Jaymie Moore Turechek & Jenny E. Hinshaw & Michael M. Kozlov & Ling-Gang Wu, 2022. "Molecular mechanics underlying flat-to-round membrane budding in live secretory cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Alan K. Okada & Kazuki Teranishi & Mark R. Ambroso & Jose Mario Isas & Elena Vazquez-Sarandeses & Joo-Yeun Lee & Arthur Alves Melo & Priyatama Pandey & Daniel Merken & Leona Berndt & Michael Lammers &, 2021. "Lysine acetylation regulates the interaction between proteins and membranes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Raviv Dharan & Yuwei Huang & Sudheer Kumar Cheppali & Shahar Goren & Petr Shendrik & Weisi Wang & Jiamei Qiao & Michael M. Kozlov & Li Yu & Raya Sorkin, 2023. "Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    4. Ewa Sitarska & Silvia Dias Almeida & Marianne Sandvold Beckwith & Julian Stopp & Jakub Czuchnowski & Marc Siggel & Rita Roessner & Aline Tschanz & Christer Ejsing & Yannick Schwab & Jan Kosinski & Mic, 2023. "Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Fanlong Wang & Xianbi Li & Yujie Li & Jing Han & Yang Chen & Jianyan Zeng & Mei Su & Jingxin Zhuo & Hui Ren & Haoru Liu & Lei Hou & Yanhua Fan & Xingying Yan & Shuiqing Song & Juan Zhao & Dan Jin & Mi, 2021. "Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    6. Rower, David A. & Atzberger, Paul J., 2023. "Coarse-grained methods for heterogeneous vesicles with phase-separated domains: Elastic mechanics of shape fluctuations, plate compression, and channel insertion," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 209(C), pages 342-361.
    7. R A Barrio & Tomas Alarcon & A Hernandez-Machado, 2020. "The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-11, January.
    8. J.I. Pavlič & T. Mareš & J. Bešter & V. Janša & M. Daniel & A. Iglič, 2009. "Encapsulation of small spherical liposome into larger flaccid liposome induced by human plasma proteins," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(2), pages 147-150.
    9. Fabian Höglsperger & Bart E. Vos & Arne D. Hofemeier & Maximilian D. Seyfried & Bastian Stövesand & Azadeh Alavizargar & Leon Topp & Andreas Heuer & Timo Betz & Bart Jan Ravoo, 2023. "Rapid and reversible optical switching of cell membrane area by an amphiphilic azobenzene," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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