IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-26727-5.html
   My bibliography  Save this article

Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae

Author

Listed:
  • Fanlong Wang

    (Southwest University)

  • Xianbi Li

    (Southwest University)

  • Yujie Li

    (Southwest University)

  • Jing Han

    (Southwest University)

  • Yang Chen

    (Southwest University)

  • Jianyan Zeng

    (Southwest University)

  • Mei Su

    (Southwest University)

  • Jingxin Zhuo

    (Southwest University)

  • Hui Ren

    (Southwest University)

  • Haoru Liu

    (Southwest University)

  • Lei Hou

    (Southwest University)

  • Yanhua Fan

    (Southwest University)

  • Xingying Yan

    (Southwest University)

  • Shuiqing Song

    (Southwest University)

  • Juan Zhao

    (Southwest University)

  • Dan Jin

    (Southwest University)

  • Mi Zhang

    (Southwest University)

  • Yan Pei

    (Southwest University)

Abstract

Many toxic secondary metabolites produced by phytopathogens can subvert host immunity, and some of them are recognized as pathogenicity factors. Fusarium head blight and Verticillium wilt are destructive plant diseases worldwide. Using toxins produced by the causal fungi Fusarium graminearum and Verticillium dahliae as screening agents, here we show that the Arabidopsis P4 ATPases AtALA1 and AtALA7 are responsible for cellular detoxification of mycotoxins. Through AtALA1-/AtALA7-mediated vesicle transport, toxins are sequestered in vacuoles for degradation. Overexpression of AtALA1 and AtALA7 significantly increases the resistance of transgenic plants to F. graminearum and V. dahliae, respectively. Notably, the concentration of deoxynivalenol, a mycotoxin harmful to the health of humans and animals, was decreased in transgenic Arabidopsis siliques and maize seeds. This vesicle-mediated cell detoxification process provides a strategy to increase plant resistance against different toxin-associated diseases and to reduce the mycotoxin contamination in food and feed.

Suggested Citation

  • Fanlong Wang & Xianbi Li & Yujie Li & Jing Han & Yang Chen & Jianyan Zeng & Mei Su & Jingxin Zhuo & Hui Ren & Haoru Liu & Lei Hou & Yanhua Fan & Xingying Yan & Shuiqing Song & Juan Zhao & Dan Jin & Mi, 2021. "Arabidopsis P4 ATPase-mediated cell detoxification confers resistance to Fusarium graminearum and Verticillium dahliae," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26727-5
    DOI: 10.1038/s41467-021-26727-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-26727-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-021-26727-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Harvey T. McMahon & Jennifer L. Gallop, 2005. "Membrane curvature and mechanisms of dynamic cell membrane remodelling," Nature, Nature, vol. 438(7068), pages 590-596, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fabian Höglsperger & Bart E. Vos & Arne D. Hofemeier & Maximilian D. Seyfried & Bastian Stövesand & Azadeh Alavizargar & Leon Topp & Andreas Heuer & Timo Betz & Bart Jan Ravoo, 2023. "Rapid and reversible optical switching of cell membrane area by an amphiphilic azobenzene," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    2. Ewa Sitarska & Silvia Dias Almeida & Marianne Sandvold Beckwith & Julian Stopp & Jakub Czuchnowski & Marc Siggel & Rita Roessner & Aline Tschanz & Christer Ejsing & Yannick Schwab & Jan Kosinski & Mic, 2023. "Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Rower, David A. & Atzberger, Paul J., 2023. "Coarse-grained methods for heterogeneous vesicles with phase-separated domains: Elastic mechanics of shape fluctuations, plate compression, and channel insertion," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 209(C), pages 342-361.
    4. J.I. Pavlič & T. Mareš & J. Bešter & V. Janša & M. Daniel & A. Iglič, 2009. "Encapsulation of small spherical liposome into larger flaccid liposome induced by human plasma proteins," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(2), pages 147-150.
    5. R A Barrio & Tomas Alarcon & A Hernandez-Machado, 2020. "The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-11, January.
    6. Alan K. Okada & Kazuki Teranishi & Mark R. Ambroso & Jose Mario Isas & Elena Vazquez-Sarandeses & Joo-Yeun Lee & Arthur Alves Melo & Priyatama Pandey & Daniel Merken & Leona Berndt & Michael Lammers &, 2021. "Lysine acetylation regulates the interaction between proteins and membranes," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    7. Raviv Dharan & Yuwei Huang & Sudheer Kumar Cheppali & Shahar Goren & Petr Shendrik & Weisi Wang & Jiamei Qiao & Michael M. Kozlov & Li Yu & Raya Sorkin, 2023. "Tetraspanin 4 stabilizes membrane swellings and facilitates their maturation into migrasomes," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Wonchul Shin & Ben Zucker & Nidhi Kundu & Sung Hoon Lee & Bo Shi & Chung Yu Chan & Xiaoli Guo & Jonathan T. Harrison & Jaymie Moore Turechek & Jenny E. Hinshaw & Michael M. Kozlov & Ling-Gang Wu, 2022. "Molecular mechanics underlying flat-to-round membrane budding in live secretory cells," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26727-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.