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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Author

Listed:
  • S. T. Cole

    (Unité de Génétique Moléculaire Bactérienne)

  • R. Brosch

    (Unité de Génétique Moléculaire Bactérienne)

  • J. Parkhill

    (Sanger Centre, Wellcome Trust Genome Campus)

  • T. Garnier

    (Unité de Génétique Moléculaire Bactérienne)

  • C. Churcher

    (Sanger Centre, Wellcome Trust Genome Campus)

  • D. Harris

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. V. Gordon

    (Unité de Génétique Moléculaire Bactérienne)

  • K. Eiglmeier

    (Unité de Génétique Moléculaire Bactérienne)

  • S. Gas

    (Unité de Génétique Moléculaire Bactérienne)

  • C. E. Barry

    (Tuberculosis Research Unit, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • F. Tekaia

    (Unité de Génétique Moléculaire des Levures)

  • K. Badcock

    (Sanger Centre, Wellcome Trust Genome Campus)

  • D. Basham

    (Sanger Centre, Wellcome Trust Genome Campus)

  • D. Brown

    (Sanger Centre, Wellcome Trust Genome Campus)

  • T. Chillingworth

    (Sanger Centre, Wellcome Trust Genome Campus)

  • R. Connor

    (Sanger Centre, Wellcome Trust Genome Campus)

  • R. Davies

    (Sanger Centre, Wellcome Trust Genome Campus)

  • K. Devlin

    (Sanger Centre, Wellcome Trust Genome Campus)

  • T. Feltwell

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Gentles

    (Sanger Centre, Wellcome Trust Genome Campus)

  • N. Hamlin

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Holroyd

    (Sanger Centre, Wellcome Trust Genome Campus)

  • T. Hornsby

    (Sanger Centre, Wellcome Trust Genome Campus)

  • K. Jagels

    (Sanger Centre, Wellcome Trust Genome Campus)

  • A. Krogh

    (Center for Biological Sequence Analysis, Technical University of Denmark)

  • J. McLean

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Moule

    (Sanger Centre, Wellcome Trust Genome Campus)

  • L. Murphy

    (Sanger Centre, Wellcome Trust Genome Campus)

  • K. Oliver

    (Sanger Centre, Wellcome Trust Genome Campus)

  • J. Osborne

    (Sanger Centre, Wellcome Trust Genome Campus)

  • M. A. Quail

    (Sanger Centre, Wellcome Trust Genome Campus)

  • M.-A. Rajandream

    (Sanger Centre, Wellcome Trust Genome Campus)

  • J. Rogers

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Rutter

    (Sanger Centre, Wellcome Trust Genome Campus)

  • K. Seeger

    (Sanger Centre, Wellcome Trust Genome Campus)

  • J. Skelton

    (Sanger Centre, Wellcome Trust Genome Campus)

  • R. Squares

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Squares

    (Sanger Centre, Wellcome Trust Genome Campus)

  • J. E. Sulston

    (Sanger Centre, Wellcome Trust Genome Campus)

  • K. Taylor

    (Sanger Centre, Wellcome Trust Genome Campus)

  • S. Whitehead

    (Sanger Centre, Wellcome Trust Genome Campus)

  • B. G. Barrell

    (Sanger Centre, Wellcome Trust Genome Campus)

Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

Suggested Citation

  • S. T. Cole & R. Brosch & J. Parkhill & T. Garnier & C. Churcher & D. Harris & S. V. Gordon & K. Eiglmeier & S. Gas & C. E. Barry & F. Tekaia & K. Badcock & D. Basham & D. Brown & T. Chillingworth & R., 1998. "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence," Nature, Nature, vol. 393(6685), pages 537-544, June.
    • Handle: RePEc:nat:nature:v:393:y:1998:i:6685:d:10.1038_31159
    DOI: 10.1038/31159
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    Cited by:

    1. Elena Campos-Pardos & Santiago Uranga & Ana Picó & Ana Belén Gómez & Jesús Gonzalo-Asensio, 2024. "Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Anna G. Green & Chang Ho Yoon & Michael L. Chen & Yasha Ektefaie & Mack Fina & Luca Freschi & Matthias I. Gröschel & Isaac Kohane & Andrew Beam & Maha Farhat, 2022. "A convolutional neural network highlights mutations relevant to antimicrobial resistance in Mycobacterium tuberculosis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Pierre Dupuy & Shreya Ghosh & Oyindamola Adefisayo & John Buglino & Stewart Shuman & Michael S. Glickman, 2022. "Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Iñaki Comas & Sebastien Gagneux, 2009. "The Past and Future of Tuberculosis Research," PLOS Pathogens, Public Library of Science, vol. 5(10), pages 1-7, October.
    5. Joshua S. Woodworth & Helena Strand Clemmensen & Hannah Battey & Karin Dijkman & Thomas Lindenstrøm & Raquel Salvador Laureano & Randy Taplitz & Jeffrey Morgan & Claus Aagaard & Ida Rosenkrands & Ceci, 2021. "A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    6. Tannu Priya Gosain & Saurabh Chugh & Zaigham Abbas Rizvi & Neeraj Kumar Chauhan & Saqib Kidwai & Krishan Gopal Thakur & Amit Awasthi & Ramandeep Singh, 2024. "Mycobacterium tuberculosis strain with deletions in menT3 and menT4 is attenuated and confers protection in mice and guinea pigs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    7. Poonam Chitale & Alexander D. Lemenze & Emily C. Fogarty & Avi Shah & Courtney Grady & Aubrey R. Odom-Mabey & W. Evan Johnson & Jason H. Yang & A. Murat Eren & Roland Brosch & Pradeep Kumar & David Al, 2022. "A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Michiko Shimokawa & Akihiro Ishiwata & Toma Kashima & Chiho Nakashima & Jiaman Li & Riku Fukushima & Naomi Sawai & Miku Nakamori & Yuuki Tanaka & Azusa Kudo & Sae Morikami & Nao Iwanaga & Genki Akai &, 2023. "Identification and characterization of endo-α-, exo-α-, and exo-β-d-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    9. Eugene B. Postnikov & Andrey A. Khalin & Anastasia I. Lavrova & Olga A. Manicheva, 2019. "Resazurin Assay Data for Mycobacterium tuberculosis Supporting a Model of the Growth Accelerated by a Stochastic Non-Homogeneity," Data, MDPI, vol. 4(1), pages 1-8, February.
    10. Cheng Bei & Junhao Zhu & Peter H. Culviner & Mingyu Gan & Eric J. Rubin & Sarah M. Fortune & Qian Gao & Qingyun Liu, 2024. "Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    11. Yuzhe Weng & Dawn Shepherd & Yi Liu & Nitya Krishnan & Brian D. Robertson & Nick Platt & Gerald Larrouy-Maumus & Frances M. Platt, 2022. "Inhibition of the Niemann-Pick C1 protein is a conserved feature of multiple strains of pathogenic mycobacteria," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    12. Tiago Beites & Robert S. Jansen & Ruojun Wang & Adrian Jinich & Kyu Y. Rhee & Dirk Schnappinger & Sabine Ehrt, 2021. "Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    13. Matthias F. Block & Cyrille L. Delley & Lena M. L. Keller & Timo T. Stuehlinger & Eilika Weber-Ban, 2023. "Electrostatic interactions guide substrate recognition of the prokaryotic ubiquitin-like protein ligase PafA," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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