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Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis

Author

Listed:
  • Cheng Bei

    (Fudan University)

  • Junhao Zhu

    (Harvard T. H. Chan School of Public Health
    Chinese Academy of Sciences)

  • Peter H. Culviner

    (Harvard T. H. Chan School of Public Health)

  • Mingyu Gan

    (National Children’s Medical Center)

  • Eric J. Rubin

    (Harvard T. H. Chan School of Public Health)

  • Sarah M. Fortune

    (Harvard T. H. Chan School of Public Health)

  • Qian Gao

    (Fudan University
    Shenzhen Third People’s Hospital)

  • Qingyun Liu

    (Harvard T. H. Chan School of Public Health
    University of North Carolina at Chapel Hill)

Abstract

Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to changing environments, yet the concept of transcriptional plasticity (TP) – the variability of gene expression in response to environmental changes – remains largely unexplored. In this study, we investigate the genome-wide TP profiles of Mycobacterium tuberculosis (Mtb) genes by analyzing 894 RNA sequencing samples derived from 73 different environmental conditions. Our data reveal that Mtb genes exhibit significant TP variation that correlates with gene function and gene essentiality. We also find that critical genetic features, such as gene length, GC content, and operon size independently impose constraints on TP, beyond trans-regulation. By extending our analysis to include two other Mycobacterium species -- M. smegmatis and M. abscessus -- we demonstrate a striking conservation of the TP landscape. This study provides a comprehensive understanding of the TP exhibited by mycobacteria genes, shedding light on this significant, yet understudied, genetic feature encoded in bacterial genomes.

Suggested Citation

  • Cheng Bei & Junhao Zhu & Peter H. Culviner & Mingyu Gan & Eric J. Rubin & Sarah M. Fortune & Qian Gao & Qingyun Liu, 2024. "Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47410-5
    DOI: 10.1038/s41467-024-47410-5
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