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Shared genetic architectures of educational attainment in East Asian and European populations

Author

Listed:
  • Tzu-Ting Chen

    (National Health Research Institutes)

  • Jaeyoung Kim

    (Samsung Medical Center
    Seoul National University Bundang Hospital)

  • Max Lam

    (Massachusetts General Hospital
    Harvard Medical School
    Genome Institute of Singapore
    Northwell Health)

  • Yi-Fang Chuang

    (National Yang Ming Chiao Tung University)

  • Yen-Ling Chiu

    (Yuan Ze University
    Far Eastern Memorial Hospital)

  • Shu-Chin Lin

    (National Health Research Institutes)

  • Sang-Hyuk Jung

    (University of Pennsylvania)

  • Beomsu Kim

    (Samsung Medical Center)

  • Soyeon Kim

    (Massachusetts General Hospital
    the Broad Institute of MIT and Harvard)

  • Chamlee Cho

    (Samsung Medical Center)

  • Injeong Shim

    (Samsung Medical Center)

  • Sanghyeon Park

    (Samsung Medical Center)

  • Yeeun Ahn

    (Samsung Medical Center)

  • Aysu Okbay

    (Vrije Universiteit Amsterdam)

  • Hyemin Jang

    (Sungkyunkwan University School of Medicine
    Samsung Medical Center)

  • Hee Jin Kim

    (Sungkyunkwan University School of Medicine
    Samsung Medical Center)

  • Sang Won Seo

    (Sungkyunkwan University School of Medicine
    Samsung Medical Center)

  • Woong-Yang Park

    (Sungkyunkwan University School of Medicine)

  • Tian Ge

    (the Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Harvard Medical School)

  • Hailiang Huang

    (Massachusetts General Hospital
    Harvard Medical School
    the Broad Institute of MIT and Harvard)

  • Yen-Chen Anne Feng

    (National Taiwan University
    National Taiwan University)

  • Yen-Feng Lin

    (National Health Research Institutes
    National Yang Ming Chiao Tung University
    National Cheng Kung University)

  • Woojae Myung

    (Seoul National University Bundang Hospital
    Seoul National University College of Medicine)

  • Chia-Yen Chen

    (Biogen)

  • Hong-Hee Won

    (Samsung Medical Center
    Sungkyunkwan University School of Medicine)

Abstract

Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.

Suggested Citation

  • Tzu-Ting Chen & Jaeyoung Kim & Max Lam & Yi-Fang Chuang & Yen-Ling Chiu & Shu-Chin Lin & Sang-Hyuk Jung & Beomsu Kim & Soyeon Kim & Chamlee Cho & Injeong Shim & Sanghyeon Park & Yeeun Ahn & Aysu Okbay, 2024. "Shared genetic architectures of educational attainment in East Asian and European populations," Nature Human Behaviour, Nature, vol. 8(3), pages 562-575, March.
    • Handle: RePEc:nat:nathum:v:8:y:2024:i:3:d:10.1038_s41562-023-01781-9
    DOI: 10.1038/s41562-023-01781-9
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