IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-44701-9.html
   My bibliography  Save this article

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

Author

Listed:
  • Rosalie B. T. M. Sterenborg

    (Radboud University Medical Center
    Erasmus Medical Center)

  • Inga Steinbrenner

    (Faculty of Medicine and Medical Center - University of Freiburg)

  • Yong Li

    (Faculty of Medicine and Medical Center - University of Freiburg)

  • Melissa N. Bujnis

    (The University of Utah)

  • Tatsuhiko Naito

    (Osaka University Graduate School of Medicine
    RIKEN Center for Integrative Medical Sciences)

  • Eirini Marouli

    (Queen Mary University of London
    Queen Mary University of London)

  • Tessel E. Galesloot

    (Radboud University Medical Center)

  • Oladapo Babajide

    (Queen Mary University of London)

  • Laura Andreasen

    (Copenhagen University Hospital - Rigshospitalet
    University of Copenhagen)

  • Arne Astrup

    (The Novo Nordisk Foundation)

  • Bjørn Olav Åsvold

    (NTNU, Norwegian University of Science and Technology
    Trondheim University Hospital)

  • Stefania Bandinelli

    (Geriatric Unit, Azienda Sanitaria Toscana Centro)

  • Marian Beekman

    (Leiden University Medical Center)

  • John P. Beilby

    (The University of Western Australia)

  • Jette Bork-Jensen

    (University of Copenhagen)

  • Thibaud Boutin

    (University of Edinburgh, Western General Hospital)

  • Jennifer A. Brody

    (University of Washington)

  • Suzanne J. Brown

    (Sir Charles Gairdner Hospital)

  • Ben Brumpton

    (NTNU, Norwegian University of Science and Technology
    Norwegian University of Science and Technology)

  • Purdey J. Campbell

    (Sir Charles Gairdner Hospital)

  • Anne R. Cappola

    (University of Pennsylvania)

  • Graziano Ceresini

    (University of Parma
    Azienda Ospedaliero-Universitaria di Parma)

  • Layal Chaker

    (Erasmus Medical Center
    University Medical Centre
    Harvard T.H. Chan School of Public Health)

  • Daniel I. Chasman

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Maria Pina Concas

    (Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”)

  • Rodrigo Coutinho de Almeida

    (Leiden University Medical Center)

  • Simone M. Cross

    (QIMR Berghofer Medical Research Institute)

  • Francesco Cucca

    (Consiglio Nazionale delle Ricerche
    Università di Sassari, Dipartimento di Scienze Biomediche, V.le San Pietro)

  • Ian J. Deary

    (University of Edinburgh)

  • Alisa Devedzic Kjaergaard

    (Aarhus University Hospital)

  • Justin B. Echouffo Tcheugui

    (Johns Hopkins School of Medicine)

  • Christina Ellervik

    (Harvard Medical School
    University of Copenhagen
    Boston Children’s Hospital
    Zealand University Hospital)

  • Johan G. Eriksson

    (University of Helsinki
    National University Singapore, Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology)

  • Luigi Ferrucci

    (Longitudinal Study Section, National Institute on Aging)

  • Jan Freudenberg

    (Regeneron Pharmaceuticals, Inc., Tarrytown)

  • Christian Fuchsberger

    (Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research)

  • Christian Gieger

    (Institute of Epidemiology, Helmholtz Zentrum München)

  • Franco Giulianini

    (Brigham and Women’s Hospital)

  • Martin Gögele

    (Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research)

  • Sarah E. Graham

    (Cardiology, University of Michigan)

  • Niels Grarup

    (University of Copenhagen)

  • Ivana Gunjača

    (University of Split, School of Medicine)

  • Torben Hansen

    (University of Copenhagen)

  • Barbara N. Harding

    (University of Washington
    Barcelona Institute for Global Health)

  • Sarah E. Harris

    (University of Edinburgh)

  • Stig Haunsø

    (Copenhagen University Hospital - Rigshospitalet
    University of Copenhagen)

  • Caroline Hayward

    (University of Edinburgh, Western General Hospital)

  • Jennie Hui

    (Pathwest Laboratory Medicine WA
    The University of Western Australia)

  • Till Ittermann

    (University Medicine Greifswald
    DZHK (German Center for Cardiovascular Research), partner site Greifswald)

  • J. Wouter Jukema

    (Leiden University Medical Center
    Netherlands Heart Institute)

  • Eero Kajantie

    (Population Health Unit, Helsinki and Oulu
    Oulu University Hospital and University of Oulu
    Norwegian University of Science and Technology)

  • Jørgen K. Kanters

    (University of Copenhagen
    University of California San Francisco)

  • Line L. Kårhus

    (Bispebjerg and Frederiksberg Hospital)

  • Lambertus A. L. M. Kiemeney

    (Radboud University Medical Center
    Radboud University Medical Center)

  • Margreet Kloppenburg

    (Leiden University Medical Center)

  • Brigitte Kühnel

    (Institute of Epidemiology, Helmholtz Zentrum München)

  • Jari Lahti

    (University of Helsinki)

  • Claudia Langenberg

    (University of Cambridge School of Clinical Medicine
    Berlin Institute of Health at Charité – Universitätsmedizin Berlin
    Precision Healthcare University Research Institute, Queen Mary University of London)

  • Bruno Lapauw

    (Ghent University Hospital, C. Heymanslaan 10)

  • Graham Leese

    (NHS Tayside)

  • Shuo Li

    (Boston University)

  • David C. M. Liewald

    (University of Edinburgh)

  • Allan Linneberg

    (University of California San Francisco
    University of Copenhagen)

  • Jesus V. T. Lominchar

    (University of Copenhagen)

  • Jian’an Luan

    (University of Cambridge School of Clinical Medicine)

  • Nicholas G. Martin

    (QIMR Berghofer Medical Research Institute)

  • Antonela Matana

    (University of Split, School of Medicine)

  • Marcel E. Meima

    (Erasmus Medical Center)

  • Thomas Meitinger

    (Technical University of Munich)

  • Ingrid Meulenbelt

    (Leiden University Medical Center)

  • Braxton D. Mitchell

    (University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition
    Baltimore Veterans Administration Medical Center)

  • Line T. Møllehave

    (Bispebjerg and Frederiksberg Hospital)

  • Samia Mora

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Silvia Naitza

    (Consiglio Nazionale delle Ricerche)

  • Matthias Nauck

    (DZHK (German Center for Cardiovascular Research), partner site Greifswald
    University Medicine Greifswald)

  • Romana T. Netea-Maier

    (Radboud University Medical Center)

  • Raymond Noordam

    (Leiden University Medical Center)

  • Casia Nursyifa

    (University of Copenhagen)

  • Yukinori Okada

    (Osaka University Graduate School of Medicine
    RIKEN Center for Integrative Medical Sciences
    Graduate School of Medicine, the University of Tokyo
    Immunology Frontier Research Center (WPI-IFReC), Osaka University)

  • Stefano Onano

    (Consiglio Nazionale delle Ricerche)

  • Areti Papadopoulou

    (Queen Mary University of London)

  • Colin N. A. Palmer

    (School of Medicine, University of Dundee)

  • Cristian Pattaro

    (Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research)

  • Oluf Pedersen

    (University of Copenhagen
    Herlev-Gentofte University Hospital)

  • Annette Peters

    (German Research Center for Environmental Health
    Ludwig-Maximilians-Universität München)

  • Maik Pietzner

    (University of Cambridge School of Clinical Medicine
    Berlin Institute of Health at Charité – Universitätsmedizin Berlin
    Precision Healthcare University Research Institute, Queen Mary University of London)

  • Ozren Polašek

    (University of Split, School of Medicine
    Algebra University College)

  • Peter P. Pramstaller

    (Institute for Biomedicine (affiliated with the University of Lübeck), Eurac Research)

  • Bruce M. Psaty

    (University of Washington
    University of Washington)

  • Ante Punda

    (University Hospital Split)

  • Debashree Ray

    (Johns Hopkins Bloomberg School of Public Health)

  • Paul Redmond

    (University of Edinburgh)

  • J. Brent Richards

    (Jewish General Hospital, Montreal)

  • Paul M. Ridker

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Tom C. Russ

    (University of Edinburgh
    University of Edinburgh)

  • Kathleen A. Ryan

    (University of Maryland School of Medicine, Division of Endocrinology, Diabetes and Nutrition)

  • Morten Salling Olesen

    (Copenhagen University Hospital - Rigshospitalet
    University of Copenhagen)

  • Ulla T. Schultheiss

    (Faculty of Medicine and Medical Center - University of Freiburg
    Faculty of Medicine and Medical Center – University of Freiburg)

  • Elizabeth Selvin

    (Johns Hopkins Bloomberg School of Public Health)

  • Moneeza K. Siddiqui

    (Queen Mary University of London)

  • Carlo Sidore

    (Consiglio Nazionale delle Ricerche)

  • P. Eline Slagboom

    (Leiden University Medical Center)

  • Thorkild I. A. Sørensen

    (University of Copenhagen
    University of Copenhagen)

  • Enrique Soto-Pedre

    (School of Medicine, University of Dundee)

  • Tim D. Spector

    (King’s College London, St Thomas’ Campus)

  • Beatrice Spedicati

    (Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”
    University of Trieste)

  • Sundararajan Srinivasan

    (School of Medicine, University of Dundee)

  • John M. Starr

    (University of Edinburgh)

  • David J. Stott

    (University of Glasgow)

  • Toshiko Tanaka

    (Longitudinal Study Section, National Institute on Aging)

  • Vesela Torlak

    (University Hospital Split)

  • Stella Trompet

    (Leiden University Medical Center
    Leiden University Medical Center)

  • Johanna Tuhkanen

    (University of Helsinki)

  • André G. Uitterlinden

    (Erasmus Medical Center)

  • Erik B. Akker

    (Leiden University Medical Center
    Leiden University Medical Center
    Delft University of Technology)

  • Tibbert Eynde

    (Precision Healthcare University Research Institute, Queen Mary University of London)

  • Melanie M. Klauw

    (University of Groningen, University Medical Center Groningen)

  • Diana Heemst

    (Leiden University Medical Center)

  • Charlotte Verroken

    (Ghent University Hospital, C. Heymanslaan 10)

  • W. Edward Visser

    (Erasmus Medical Center)

  • Dina Vojinovic

    (Leiden University Medical Center
    University Medical Centre)

  • Henry Völzke

    (University Medicine Greifswald
    DZHK (German Center for Cardiovascular Research), partner site Greifswald)

  • Melanie Waldenberger

    (Institute of Epidemiology, Helmholtz Zentrum München)

  • John P. Walsh

    (Sir Charles Gairdner Hospital
    The University of Western Australia)

  • Nicholas J. Wareham

    (University of Cambridge School of Clinical Medicine)

  • Stefan Weiss

    (DZHK (German Center for Cardiovascular Research), partner site Greifswald
    University Medicine Greifswald)

  • Cristen J. Willer

    (Cardiology, University of Michigan)

  • Scott G. Wilson

    (The University of Western Australia
    Sir Charles Gairdner Hospital
    King’s College London, St Thomas’ Campus)

  • Bruce H. R. Wolffenbuttel

    (University of Groningen, University Medical Center Groningen)

  • Hanneke J. C. M. Wouters

    (University of Groningen, University Medical Center Groningen)

  • Margaret J. Wright

    (University of Queensland)

  • Qiong Yang

    (Boston University)

  • Tatijana Zemunik

    (University of Split, School of Medicine
    University Hospital Split)

  • Wei Zhou

    (Massachusetts General Hospital
    Broad Institute of Harvard and MIT)

  • Gu Zhu

    (QIMR Berghofer Medical Research Institute)

  • Sebastian Zöllner

    (University of Michigan
    University of Michigan)

  • Johannes W. A. Smit

    (Radboud University Medical Center)

  • Robin P. Peeters

    (Erasmus Medical Center)

  • Anna Köttgen

    (Faculty of Medicine and Medical Center - University of Freiburg
    Johns Hopkins Bloomberg School of Public Health
    Albert-Ludwigs-Universität Freiburg)

  • Alexander Teumer

    (University Medicine Greifswald
    DZHK (German Center for Cardiovascular Research), partner site Greifswald
    University Medicine Greifswald
    Medical University of Bialystok)

  • Marco Medici

    (Radboud University Medical Center
    Erasmus Medical Center)

Abstract

To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We revealed 259 independent significant associations for TSH (61% novel), 85 for FT4 (67% novel), and 62 novel signals for the T3 related traits. The loci explained 14.1%, 6.0%, 9.5% and 1.1% of the total variation in TSH, FT4, total T3 and free T3 concentrations, respectively. Genetic correlations indicate that TSH associated loci reflect the thyroid function determined by free T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.

Suggested Citation

  • Rosalie B. T. M. Sterenborg & Inga Steinbrenner & Yong Li & Melissa N. Bujnis & Tatsuhiko Naito & Eirini Marouli & Tessel E. Galesloot & Oladapo Babajide & Laura Andreasen & Arne Astrup & Bjørn Olav Å, 2024. "Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44701-9
    DOI: 10.1038/s41467-024-44701-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-44701-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-44701-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Clare Bycroft & Colin Freeman & Desislava Petkova & Gavin Band & Lloyd T. Elliott & Kevin Sharp & Allan Motyer & Damjan Vukcevic & Olivier Delaneau & Jared O’Connell & Adrian Cortes & Samantha Welsh &, 2018. "The UK Biobank resource with deep phenotyping and genomic data," Nature, Nature, vol. 562(7726), pages 203-209, October.
    2. Wei Zhou & Ben Brumpton & Omer Kabil & Julius Gudmundsson & Gudmar Thorleifsson & Josh Weinstock & Matthew Zawistowski & Jonas B. Nielsen & Layal Chaker & Marco Medici & Alexander Teumer & Silvia Nait, 2020. "GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    3. Tune H. Pers & Juha M. Karjalainen & Yingleong Chan & Harm-Jan Westra & Andrew R. Wood & Jian Yang & Julian C. Lui & Sailaja Vedantam & Stefan Gustafsson & Tonu Esko & Tim Frayling & Elizabeth K. Spel, 2015. "Biological interpretation of genome-wide association studies using predicted gene functions," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    4. Julius Gudmundsson & Gudmar Thorleifsson & Jon K. Sigurdsson & Lilja Stefansdottir & Jon G. Jonasson & Sigurjon A. Gudjonsson & Daniel F. Gudbjartsson & Gisli Masson & Hrefna Johannsdottir & Gisli H. , 2017. "A genome-wide association study yields five novel thyroid cancer risk loci," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
    5. Sonia Shah & Albert Henry & Carolina Roselli & Honghuang Lin & Garðar Sveinbjörnsson & Ghazaleh Fatemifar & Åsa K. Hedman & Jemma B. Wilk & Michael P. Morley & Mark D. Chaffin & Anna Helgadottir & Nie, 2020. "Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    6. Saedis Saevarsdottir & Thorunn A. Olafsdottir & Erna V. Ivarsdottir & Gisli H. Halldorsson & Kristbjorg Gunnarsdottir & Asgeir Sigurdsson & Ari Johannesson & Jon K. Sigurdsson & Thorhildur Juliusdotti, 2020. "FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease," Nature, Nature, vol. 584(7822), pages 619-623, August.
    7. Alexander Teumer & Layal Chaker & Stefan Groeneweg & Yong Li & Celia Di Munno & Caterina Barbieri & Ulla T. Schultheiss & Michela Traglia & Tarunveer S. Ahluwalia & Masato Akiyama & Emil Vincent R. Ap, 2018. "Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    8. Garan Jones & Katerina Trajanoska & Adam J. Santanasto & Najada Stringa & Chia-Ling Kuo & Janice L. Atkins & Joshua R. Lewis & ThuyVy Duong & Shengjun Hong & Mary L. Biggs & Jian’an Luan & Chloe Sarno, 2021. "Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    9. Christiaan A de Leeuw & Joris M Mooij & Tom Heskes & Danielle Posthuma, 2015. "MAGMA: Generalized Gene-Set Analysis of GWAS Data," PLOS Computational Biology, Public Library of Science, vol. 11(4), pages 1-19, April.
    10. Kyoko Watanabe & Erdogan Taskesen & Arjen Bochoven & Danielle Posthuma, 2017. "Functional mapping and annotation of genetic associations with FUMA," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    11. Peter N. Taylor & Eleonora Porcu & Shelby Chew & Purdey J. Campbell & Michela Traglia & Suzanne J. Brown & Benjamin H. Mullin & Hashem A. Shihab & Josine Min & Klaudia Walter & Yasin Memari & Jie Huan, 2015. "Whole-genome sequence-based analysis of thyroid function," Nature Communications, Nature, vol. 6(1), pages 1-11, May.
    12. Sarah E. Graham & Shoa L. Clarke & Kuan-Han H. Wu & Stavroula Kanoni & Greg J. M. Zajac & Shweta Ramdas & Ida Surakka & Ioanna Ntalla & Sailaja Vedantam & Thomas W. Winkler & Adam E. Locke & Eirini Ma, 2021. "The power of genetic diversity in genome-wide association studies of lipids," Nature, Nature, vol. 600(7890), pages 675-679, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiaofeng Zhu & Yihe Yang & Noah Lorincz-Comi & Gen Li & Amy R. Bentley & Paul S. de Vries & Michael Brown & Alanna C. Morrison & Charles N. Rotimi & W. James Gauderman & Dabeeru C. Rao & Hugues Aschar, 2024. "An approach to identify gene-environment interactions and reveal new biological insight in complex traits," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Alexander T. Williams & Jing Chen & Kayesha Coley & Chiara Batini & Abril Izquierdo & Richard Packer & Erik Abner & Stavroula Kanoni & David J. Shepherd & Robert C. Free & Edward J. Hollox & Nigel J. , 2023. "Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Michael G. Levin & Noah L. Tsao & Pankhuri Singhal & Chang Liu & Ha My T. Vy & Ishan Paranjpe & Joshua D. Backman & Tiffany R. Bellomo & William P. Bone & Kiran J. Biddinger & Qin Hui & Ozan Dikilitas, 2022. "Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Sophie A. Riesmeijer & Zoha Kamali & Michael Ng & Dmitriy Drichel & Bram Piersma & Kerstin Becker & Thomas B. Layton & Jagdeep Nanchahal & Michael Nothnagel & Ahmad Vaez & Hans Christian Hennies & Pau, 2024. "A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren’s disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Zhiqiang Sha & Dick Schijven & Amaia Carrion-Castillo & Marc Joliot & Bernard Mazoyer & Simon E. Fisher & Fabrice Crivello & Clyde Francks, 2021. "The genetic architecture of structural left–right asymmetry of the human brain," Nature Human Behaviour, Nature, vol. 5(9), pages 1226-1239, September.
    6. Catherine M. Francis & Matthias E. Futschik & Jian Huang & Wenjia Bai & Muralidharan Sargurupremraj & Alexander Teumer & Monique M. B. Breteler & Enrico Petretto & Amanda S. R. Ho & Philippe Amouyel &, 2022. "Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Milton Pividori & Sumei Lu & Binglan Li & Chun Su & Matthew E. Johnson & Wei-Qi Wei & Qiping Feng & Bahram Namjou & Krzysztof Kiryluk & Iftikhar J. Kullo & Yuan Luo & Blair D. Sullivan & Benjamin F. V, 2023. "Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    8. Danielle Rasooly & Gina M. Peloso & Alexandre C. Pereira & Hesam Dashti & Claudia Giambartolomei & Eleanor Wheeler & Nay Aung & Brian R. Ferolito & Maik Pietzner & Eric H. Farber-Eger & Quinn Stanton , 2023. "Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    9. Charley Xia & Sarah J. Pickett & David C. M. Liewald & Alexander Weiss & Gavin Hudson & W. David Hill, 2023. "The contributions of mitochondrial and nuclear mitochondrial genetic variation to neuroticism," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    10. Tzu-Ting Chen & Jaeyoung Kim & Max Lam & Yi-Fang Chuang & Yen-Ling Chiu & Shu-Chin Lin & Sang-Hyuk Jung & Beomsu Kim & Soyeon Kim & Chamlee Cho & Injeong Shim & Sanghyeon Park & Yeeun Ahn & Aysu Okbay, 2024. "Shared genetic architectures of educational attainment in East Asian and European populations," Nature Human Behaviour, Nature, vol. 8(3), pages 562-575, March.
    11. Saredo Said & Raha Pazoki & Ville Karhunen & Urmo Võsa & Symen Ligthart & Barbara Bodinier & Fotios Koskeridis & Paul Welsh & Behrooz Z. Alizadeh & Daniel I. Chasman & Naveed Sattar & Marc Chadeau-Hya, 2022. "Genetic analysis of over half a million people characterises C-reactive protein loci," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    12. Xiao-Yu He & Bang-Sheng Wu & Liu Yang & Yu Guo & Yue-Ting Deng & Ze-Yu Li & Chen-Jie Fei & Wei-Shi Liu & Yi-Jun Ge & Jujiao Kang & Jianfeng Feng & Wei Cheng & Qiang Dong & Jin-Tai Yu, 2024. "Genetic associations of protein-coding variants in venous thromboembolism," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    13. Waheed-Ul-Rahman Ahmed & Sam Kleeman & Michael Ng & Wei Wang & Adam Auton & Regent Lee & Ashok Handa & Krina T. Zondervan & Akira Wiberg & Dominic Furniss, 2022. "Genome-wide association analysis and replication in 810,625 individuals with varicose veins," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    14. Ashley Budu-Aggrey & Anna Kilanowski & Maria K. Sobczyk & Suyash S. Shringarpure & Ruth Mitchell & Kadri Reis & Anu Reigo & Reedik Mägi & Mari Nelis & Nao Tanaka & Ben M. Brumpton & Laurent F. Thomas , 2023. "European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    15. Caibo Ning & Linyun Fan & Meng Jin & Wenji Wang & Zhiqiang Hu & Yimin Cai & Liangkai Chen & Zequn Lu & Ming Zhang & Can Chen & Yanmin Li & Fuwei Zhang & Wenzhuo Wang & Yizhuo Liu & Shuoni Chen & Yuan , 2023. "Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    16. Benjamin B. Sun & Stephanie J. Loomis & Fabrizio Pizzagalli & Natalia Shatokhina & Jodie N. Painter & Christopher N. Foley & Megan E. Jensen & Donald G. McLaren & Sai Spandana Chintapalli & Alyssa H. , 2022. "Genetic map of regional sulcal morphology in the human brain from UK biobank data," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    17. Eeva Sliz & Jaakko S. Tyrmi & Nilufer Rahmioglu & Krina T. Zondervan & Christian M. Becker & Outi Uimari & Johannes Kettunen, 2023. "Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    18. Jacob Joseph & Chang Liu & Qin Hui & Krishna Aragam & Zeyuan Wang & Brian Charest & Jennifer E. Huffman & Jacob M. Keaton & Todd L. Edwards & Serkalem Demissie & Luc Djousse & Juan P. Casas & J. Micha, 2022. "Genetic architecture of heart failure with preserved versus reduced ejection fraction," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    19. Gianmarco Mignogna & Caitlin E. Carey & Robbee Wedow & Nikolas Baya & Mattia Cordioli & Nicola Pirastu & Rino Bellocco & Kathryn Fiuza Malerbi & Michel G. Nivard & Benjamin M. Neale & Raymond K. Walte, 2023. "Patterns of item nonresponse behaviour to survey questionnaires are systematic and associated with genetic loci," Nature Human Behaviour, Nature, vol. 7(8), pages 1371-1387, August.
    20. Chamlee Cho & Beomsu Kim & Dan Say Kim & Mi Yeong Hwang & Injeong Shim & Minku Song & Yeong Chan Lee & Sang-Hyuk Jung & Sung Kweon Cho & Woong-Yang Park & Woojae Myung & Bong-Jo Kim & Ron Do & Hyon K., 2024. "Large-scale cross-ancestry genome-wide meta-analysis of serum urate," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44701-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.