Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-025-56711-2
Download full text from publisher
References listed on IDEAS
- Shashank Dadsena & Rodrigo Cuevas Arenas & Gonçalo Vieira & Susanne Brodesser & Manuel N. Melo & Ana J. García-Sáez, 2024. "Lipid unsaturation promotes BAX and BAK pore activity during apoptosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Yilei Zhang & Robert V. Swanda & Litong Nie & Xiaoguang Liu & Chao Wang & Hyemin Lee & Guang Lei & Chao Mao & Pranavi Koppula & Weijie Cheng & Jie Zhang & Zhenna Xiao & Li Zhuang & Bingliang Fang & Ju, 2021. "mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
- Zhennan Shi & Nathchar Naowarojna & Zijian Pan & Yilong Zou, 2021. "Multifaceted mechanisms mediating cystine starvation-induced ferroptosis," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
- Zhiwen Ding & Yufei Pan & Taiyu Shang & Tianyi Jiang & Yunkai Lin & Chun Yang & Shujie Pang & Xiaowen Cui & Yixiu Wang & Xiao fan Feng & Mengyou Xu & Mengmiao Pei & Yibin Chen & Xin Li & Jin Ding & Ye, 2023. "URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Florencio Porto Freitas & Hamed Alborzinia & Ancély Ferreira dos Santos & Palina Nepachalovich & Lohans Pedrera & Omkar Zilka & Alex Inague & Corinna Klein & Nesrine Aroua & Kamini Kaushal & Bettina K, 2024. "7-Dehydrocholesterol is an endogenous suppressor of ferroptosis," Nature, Nature, vol. 626(7998), pages 401-410, February.
- Sebastian Doll & Florencio Porto Freitas & Ron Shah & Maceler Aldrovandi & Milene Costa Silva & Irina Ingold & Andrea Goya Grocin & Thamara Nishida Xavier da Silva & Elena Panzilius & Christina H. Sch, 2019. "FSP1 is a glutathione-independent ferroptosis suppressor," Nature, Nature, vol. 575(7784), pages 693-698, November.
- Caterina Bartolacci & Cristina Andreani & Gonçalo Vale & Stefano Berto & Margherita Melegari & Anna Colleen Crouch & Dodge L. Baluya & George Kemble & Kurt Hodges & Jacqueline Starrett & Katerina Poli, 2022. "Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
- Yilong Zou & Whitney S. Henry & Emily L. Ricq & Emily T. Graham & Vaishnavi V. Phadnis & Pema Maretich & Sateja Paradkar & Natalie Boehnke & Amy A. Deik & Ferenc Reinhardt & John K. Eaton & Bryan Ferg, 2020. "Plasticity of ether lipids promotes ferroptosis susceptibility and evasion," Nature, Nature, vol. 585(7826), pages 603-608, September.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Mihee Oh & Seo Young Jang & Ji-Yoon Lee & Jong Woo Kim & Youngae Jung & Jiwoo Kim & Jinho Seo & Tae-Su Han & Eunji Jang & Hye Young Son & Dain Kim & Min Wook Kim & Jin-Sung Park & Kwon-Ho Song & Kyoun, 2023. "The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Xin Chen & Jun Huang & Chunhua Yu & Jiao Liu & Wanli Gao & Jingbo Li & Xinxin Song & Zhuan Zhou & Changfeng Li & Yangchun Xie & Guido Kroemer & Jinbao Liu & Daolin Tang & Rui Kang, 2022. "A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Pranavi Koppula & Guang Lei & Yilei Zhang & Yuelong Yan & Chao Mao & Lavanya Kondiparthi & Jiejun Shi & Xiaoguang Liu & Amber Horbath & Molina Das & Wei Li & Masha V. Poyurovsky & Kellen Olszewski & B, 2022. "A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Xinyi Shan & Jiahuan Li & Jiahao Liu & Baoli Feng & Ting Zhang & Qian Liu & Huixin Ma & Honghong Wu & Hao Wu, 2023. "Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Hyemin Lee & Amber Horbath & Lavanya Kondiparthi & Jitendra Kumar Meena & Guang Lei & Shayani Dasgupta & Xiaoguang Liu & Li Zhuang & Pranavi Koppula & Mi Li & Iqbal Mahmud & Bo Wei & Philip L. Lorenzi, 2024. "Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Xiaofeng Sun & Chengjian Zhou & Simin Xia & Xi Chen, 2023. "Small molecule-nanobody conjugate induced proximity controls intracellular processes and modulates endogenous unligandable targets," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Vincent de Laat & Halit Topal & Xander Spotbeen & Ali Talebi & Jonas Dehairs & Jakub Idkowiak & Frank Vanderhoydonc & Tessa Ostyn & Peihua Zhao & Maarten Jacquemyn & Michele Wölk & Anna Sablina & Koen, 2024. "Intrinsic temperature increase drives lipid metabolism towards ferroptosis evasion and chemotherapy resistance in pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
- Bin Huang & Hui Wang & Shuo Liu & Meng Hao & Dan Luo & Yi Zhou & Ying Huang & Yong Nian & Lei Zhang & Bo Chu & Chengqian Yin, 2025. "Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
- Yandi Wu & Tongsheng Huang & Xinghui Li & Conghui Shen & Honglin Ren & Haiping Wang & Teng Wu & Xinlu Fu & Shijie Deng & Ziqi Feng & Shijie Xiong & Hui Li & Saifei Gao & Zhenyu Yang & Fei Gao & Lele D, 2023. "Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Ying Xue & Fujia Lu & Zhenzhen Chang & Jing Li & Yuan Gao & Jie Zhou & Ying Luo & Yongfeng Lai & Siyuan Cao & Xiaoxiao Li & Yuhan Zhou & Yan Li & Zheng Tan & Xiang Cheng & Xiong Li & Jing Chen & Weimi, 2023. "Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
- Yuan Zhao & Meng-Jie Liu & Lei Zhang & Qi Yang & Qian-Hui Sun & Jin-Rong Guo & Xin-Yuan Lei & Kai-Yue He & Jun-Qi Li & Jing-Yu Yang & Yong-Ping Jian & Zhi-Xiang Xu, 2024. "High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
- Zhe Wang & Xin Yang & Delin Chen & Yanqing Liu & Zhiming Li & Shoufu Duan & Zhiguo Zhang & Xuejun Jiang & Brent R. Stockwell & Wei Gu, 2024. "GAS41 modulates ferroptosis by anchoring NRF2 on chromatin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Zhi Lin & Jiao Liu & Fei Long & Rui Kang & Guido Kroemer & Daolin Tang & Minghua Yang, 2022. "The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Dadi Jiang & Youming Guo & Tianyu Wang & Liang Wang & Yuelong Yan & Ling Xia & Rakesh Bam & Zhifen Yang & Hyemin Lee & Takao Iwawaki & Boyi Gan & Albert C. Koong, 2024. "IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Ziheng Chen & I-Lin Ho & Melinda Soeung & Er-Yen Yen & Jintan Liu & Liang Yan & Johnathon L. Rose & Sanjana Srinivasan & Shan Jiang & Q. Edward Chang & Ningping Feng & Jason P. Gay & Qi Wang & Jing Wa, 2023. "Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Bartosz Wiernicki & Sophia Maschalidi & Jonathan Pinney & Sandy Adjemian & Tom Vanden Berghe & Kodi S. Ravichandran & Peter Vandenabeele, 2022. "Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Tanaz Sharifnia & Mathias J. Wawer & Amy Goodale & Yenarae Lee & Mariya Kazachkova & Joshua M. Dempster & Sandrine Muller & Joan Levy & Daniel M. Freed & Josh Sommer & Jérémie Kalfon & Francisca Vazqu, 2023. "Mapping the landscape of genetic dependencies in chordoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
- Shuling Xu & Zhijun Zhu & Daniel G. Delafield & Michael J. Rigby & Gaoyuan Lu & Megan Braun & Luigi Puglielli & Lingjun Li, 2024. "Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
- M. T. Herrera-Abreu & J. Guan & U. Khalid & J. Ning & M. R. Costa & J. Chan & Q. Li & J-P. Fortin & W. R. Wong & P. Perampalam & A. Biton & W. Sandoval & J. Vijay & M. Hafner & R. Cutts & G. Wilson & , 2024. "Inhibition of GPX4 enhances CDK4/6 inhibitor and endocrine therapy activity in breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
- Juliane Tschuck & Vidya Padmanabhan Nair & Ana Galhoz & Carole Zaratiegui & Hin-Man Tai & Gabriele Ciceri & Ina Rothenaigner & Jason Tchieu & Brent R. Stockwell & Lorenz Studer & Daphne S. Cabianca & , 2024. "Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56711-2. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.