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Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

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  • Zhennan Shi

    (Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
    Westlake University
    Institute of Biology, Westlake Institute of Advanced Studies)

  • Nathchar Naowarojna

    (Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
    Westlake University
    Institute of Biology, Westlake Institute of Advanced Studies)

  • Zijian Pan

    (Westlake University
    Institute of Biology, Westlake Institute of Advanced Studies)

  • Yilong Zou

    (Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Lab, Westlake Laboratory of Life Sciences and Biomedicine
    Westlake University
    Institute of Biology, Westlake Institute of Advanced Studies)

Abstract

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.

Suggested Citation

  • Zhennan Shi & Nathchar Naowarojna & Zijian Pan & Yilong Zou, 2021. "Multifaceted mechanisms mediating cystine starvation-induced ferroptosis," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25159-5
    DOI: 10.1038/s41467-021-25159-5
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    Cited by:

    1. Lihua Qiang & Yong Zhang & Zehui Lei & Zhe Lu & Shasha Tan & Pupu Ge & Qiyao Chai & Mengyuan Zhao & Xinwen Zhang & Bingxi Li & Yu Pang & Lingqiang Zhang & Cui Hua Liu & Jing Wang, 2023. "A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Ying Xue & Fujia Lu & Zhenzhen Chang & Jing Li & Yuan Gao & Jie Zhou & Ying Luo & Yongfeng Lai & Siyuan Cao & Xiaoxiao Li & Yuhan Zhou & Yan Li & Zheng Tan & Xiang Cheng & Xiong Li & Jing Chen & Weimi, 2023. "Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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