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The Theranostic Genome

Author

Listed:
  • Xiaoying Xu

    (University of Lucerne)

  • Pablo Jané

    (University of Geneva
    Geneva University Hospitals)

  • Vincent Taelman

    (University of Lucerne)

  • Eduardo Jané

    (Universidad Politécnica de Madrid)

  • Rebecca A. Dumont

    (University of Lucerne)

  • Yonathan Garama

    (University of Lucerne)

  • Francisco Kim

    (University of Lucerne)

  • María Val Gómez

    (Hospital Universitario Ramón y Cajal)

  • Karim Gariani

    (Geneva University Hospitals)

  • Martin A. Walter

    (University of Lucerne
    University of Lucerne)

Abstract

Theranostic drugs represent an emerging path to deliver on the promise of precision medicine. However, bottlenecks remain in characterizing theranostic targets, identifying theranostic lead compounds, and tailoring theranostic drugs. To overcome these bottlenecks, we present the Theranostic Genome, the part of the human genome whose expression can be utilized to combine therapeutic and diagnostic applications. Using a deep learning-based hybrid human-AI pipeline that cross-references PubMed, the Gene Expression Omnibus, DisGeNET, The Cancer Genome Atlas and the NIH Molecular Imaging and Contrast Agent Database, we bridge individual genes in human cancers with respective theranostic compounds. Cross-referencing the Theranostic Genome with RNAseq data from over 17’000 human tissues identifies theranostic targets and lead compounds for various human cancers, and allows tailoring targeted theranostics to relevant cancer subpopulations. We expect the Theranostic Genome to facilitate the development of new targeted theranostics to better diagnose, understand, treat, and monitor a variety of human cancers.

Suggested Citation

  • Xiaoying Xu & Pablo Jané & Vincent Taelman & Eduardo Jané & Rebecca A. Dumont & Yonathan Garama & Francisco Kim & María Val Gómez & Karim Gariani & Martin A. Walter, 2024. "The Theranostic Genome," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55291-x
    DOI: 10.1038/s41467-024-55291-x
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