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Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma

Author

Listed:
  • Fang Wang

    (Hangzhou Medical College
    The First Affiliated Hospital of Zhengzhou University)

  • Jiawei Dong

    (Hangzhou Medical College
    The Second Affiliated Hospital of Harbin Medical University)

  • Yuyun Xu

    (Hangzhou Medical College)

  • Jiaqi Jin

    (Hangzhou Medical College)

  • Yan Xu

    (Hangzhou Medical College)

  • Xiuwei Yan

    (Hangzhou Medical College)

  • Zhihui Liu

    (Hangzhou Medical College)

  • Hongtao Zhao

    (Hangzhou Medical College)

  • Jiheng Zhang

    (Hangzhou Medical College)

  • Nan Wang

    (Hangzhou Medical College)

  • Xueyan Hu

    (Hangzhou Medical College)

  • Xin Gao

    (Hangzhou Medical College)

  • Lei Xu

    (Hangzhou Medical College)

  • Chengyun Yang

    (Hangzhou Medical College)

  • Shuai Ma

    (Hangzhou Medical College)

  • Jianyang Du

    (Hangzhou Medical College)

  • Ying Hu

    (Hangzhou Medical College
    Harbin Institute of Technology)

  • Hang Ji

    (Hangzhou Medical College
    West China Hospital Sichuan University)

  • Shaoshan Hu

    (Hangzhou Medical College)

Abstract

Approximately 90% of glioblastoma recurrences occur in the peritumoral brain zone (PBZ), while the spatial heterogeneity of the PBZ is not well studied. In this study, two PBZ tissues and one tumor tissue sample are obtained from each patient via preoperative imaging. We assess the microenvironment and the characteristics of infiltrating immune/tumor cells using various techniques. Our data indicate there are one or more regions with higher cerebral blood flow in PBZ, which we collectively name the “higher cerebral blood flow interface” (HBI). The HBI exhibited more neovascularization than the “lower cerebral blood flow interfaces” (LBI). The HBI tend to have increased infiltration of macrophages and T lymphocytes infiltration compared with that in LBI. There are more tumor cells in the HBI than in LBI, with substantial differences in the gene expression profiles of these tumor cells. HBI may be the key area of PBZ-targeting therapy after surgical resection.

Suggested Citation

  • Fang Wang & Jiawei Dong & Yuyun Xu & Jiaqi Jin & Yan Xu & Xiuwei Yan & Zhihui Liu & Hongtao Zhao & Jiheng Zhang & Nan Wang & Xueyan Hu & Xin Gao & Lei Xu & Chengyun Yang & Shuai Ma & Jianyang Du & Yin, 2024. "Turning attention to tumor–host interface and focus on the peritumoral heterogeneity of glioblastoma," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-55243-5
    DOI: 10.1038/s41467-024-55243-5
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    1. Charles P. Couturier & Shamini Ayyadhury & Phuong U. Le & Javad Nadaf & Jean Monlong & Gabriele Riva & Redouane Allache & Salma Baig & Xiaohua Yan & Mathieu Bourgey & Changseok Lee & Yu Chang David Wa, 2020. "Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy," Nature Communications, Nature, vol. 11(1), pages 1-19, December.
    2. Peter Carmeliet, 2005. "Angiogenesis in life, disease and medicine," Nature, Nature, vol. 438(7070), pages 932-936, December.
    3. Soniya Bastola & Marat S. Pavlyukov & Daisuke Yamashita & Sadashib Ghosh & Heejin Cho & Noritaka Kagaya & Zhuo Zhang & Mutsuko Minata & Yeri Lee & Hirokazu Sadahiro & Shinobu Yamaguchi & Svetlana Koma, 2020. "Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy," Nature Communications, Nature, vol. 11(1), pages 1-17, December.
    4. Napoleone Ferrara & Robert S. Kerbel, 2005. "Angiogenesis as a therapeutic target," Nature, Nature, vol. 438(7070), pages 967-974, December.
    5. Philippe Mauffrey & Nicolas Tchitchek & Vilma Barroca & Alexis-Pierre Bemelmans & Virginie Firlej & Yves Allory & Paul-Henri Roméo & Claire Magnon, 2019. "Progenitors from the central nervous system drive neurogenesis in cancer," Nature, Nature, vol. 569(7758), pages 672-678, May.
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