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Angiogenesis in life, disease and medicine

Author

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  • Peter Carmeliet

    (Center of Transgene Technology and Gene Therapy, University of Leuven, Flanders Interuniversity Institute for Biotechnology (VIB))

Abstract

The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.

Suggested Citation

  • Peter Carmeliet, 2005. "Angiogenesis in life, disease and medicine," Nature, Nature, vol. 438(7070), pages 932-936, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04478
    DOI: 10.1038/nature04478
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    Cited by:

    1. Sadhukhan, Sounak & Mishra, P.K., 2022. "The notion of fractals in tumour angiogenic sprout initiation model based on cellular automata," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).
    2. Atsuya Yaguchi & Mio Oshikawa & Go Watanabe & Hirotsugu Hiramatsu & Noriyuki Uchida & Chikako Hara & Naoko Kaneko & Kazunobu Sawamoto & Takahiro Muraoka & Itsuki Ajioka, 2021. "Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Rocío Vega & Manuel Carretero & Rui D M Travasso & Luis L Bonilla, 2020. "Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model," PLOS Computational Biology, Public Library of Science, vol. 16(1), pages 1-31, January.
    4. Yuping Li & Mengzhuo Hou & Guangyu Lu & Natalia Ciccone & Xingdong Wang & Hengzhu Zhang, 2016. "The Prognosis of Anti-Angiogenesis Treatments Combined with Standard Therapy for Newly Diagnosed Glioblastoma: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-16, December.
    5. S. Kaessmeyer & H. Huenigen & S. Al Masri & P. Dieckhoefer & K. Richardson & J. Plendl, 2016. "Corpus luteal angiogenesis in a high milk production dairy breed differs from that of cattle with lower milk production levels," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 61(9), pages 497-503.
    6. Zélia Velez & Marco A. Campinho & Ângela R. Guerra & Laura García & Patricia Ramos & Olinda Guerreiro & Laura Felício & Fernando Schmitt & Maria Duarte, 2012. "Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities," Agriculture, MDPI, vol. 2(4), pages 1-21, December.
    7. Moritz Gerstung & Hani Nakhoul & Niko Beerenwinkel, 2011. "Evolutionary Games with Affine Fitness Functions: Applications to Cancer," Dynamic Games and Applications, Springer, vol. 1(3), pages 370-385, September.
    8. Hanlin Lu & Peidong Yuan & Xiaoping Ma & Xiuxin Jiang & Shaozhuang Liu & Chang Ma & Sjaak Philipsen & Qunye Zhang & Jianmin Yang & Feng Xu & Cheng Zhang & Yun Zhang & Wencheng Zhang, 2023. "Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    9. Rui D M Travasso & Eugenia Corvera Poiré & Mario Castro & Juan Carlos Rodrguez-Manzaneque & A Hernández-Machado, 2011. "Tumor Angiogenesis and Vascular Patterning: A Mathematical Model," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.

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