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Angiogenesis as a therapeutic target

Author

Listed:
  • Napoleone Ferrara

    (Genentech, 1 DNA Way)

  • Robert S. Kerbel

    (Sunnybrook and Women's College Health Sciences Centre and the University of Toronto)

Abstract

Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.

Suggested Citation

  • Napoleone Ferrara & Robert S. Kerbel, 2005. "Angiogenesis as a therapeutic target," Nature, Nature, vol. 438(7070), pages 967-974, December.
    • Handle: RePEc:nat:nature:v:438:y:2005:i:7070:d:10.1038_nature04483
    DOI: 10.1038/nature04483
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    Cited by:

    1. Xia Han & Huiqin Qi & Wenting Liu & Menghai Wu, 2020. "Effect of Sacubitril/Valsartan on VEGF, VEGFR-1 and Left Ventricular Remodeling in Patients with Heart Failure with Decreased Ejection Fraction Effect of Sacubitril/Valsartan on VEGF, VEGFR-1 and Left," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 25(3), pages 19154-19160, January.
    2. Dragica Dobrovic & Damir Pelicic & Mitar Saveljic & Dragica Dobrovic & Damir Pelicic & Mitar Saveljic, 2020. "Risk Factors for Postoperative Delirium After Cardiac Surgery at the Clinical Center of Montenegro," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 32(1), pages 24731-24735, November.
    3. Haifeng Zhang & Busu Li & Qunhua Huang & Francesc López-Giráldez & Yoshiaki Tanaka & Qun Lin & Sameet Mehta & Guilin Wang & Morven Graham & Xinran Liu & In-Hyun Park & Anne Eichmann & Wang Min & Jenny, 2022. "Mitochondrial dysfunction induces ALK5-SMAD2-mediated hypovascularization and arteriovenous malformations in mouse retinas," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    4. Rui D M Travasso & Eugenia Corvera Poiré & Mario Castro & Juan Carlos Rodrguez-Manzaneque & A Hernández-Machado, 2011. "Tumor Angiogenesis and Vascular Patterning: A Mathematical Model," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.

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