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The Arabidopsis receptor-like kinase WAKL4 limits cadmium uptake via phosphorylation and degradation of NRAMP1 transporter

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  • Jun Jie Yuan

    (Zhejiang University
    South China Agricultural University)

  • Ya Nan Zhao

    (Zhejiang University)

  • Su Hang Yu

    (Zhejiang University)

  • Ying Sun

    (Ningxia University)

  • Gui Xin Li

    (Zhejiang University)

  • Jing Ying Yan

    (Zhejiang University)

  • Ji Ming Xu

    (Zhejiang University)

  • Wo Na Ding

    (Ningbo University)

  • Moussa Benhamed

    (Institute of Plant Sciences Paris-Saclay (IPS2))

  • Rong Liang Qiu

    (South China Agricultural University)

  • Chong Wei Jin

    (Zhejiang University)

  • Shao Jian Zheng

    (Zhejiang University
    South China Agricultural University)

  • Zhong Jie Ding

    (Zhejiang University)

Abstract

Cadmium (Cd) is a detrimental heavy metal propagated from soil to the food chain via plants, posing a great risk to human health upon consumption. Despite the understanding of Cd tolerance mechanisms in plants, whether and how plants actively respond to Cd and in turn restrict its uptake and accumulation remain elusive. Here, we identify a cell wall-associated receptor-like kinase 4 (WAKL4) involved in specific tolerance to Cd stress. We show that Cd rapidly and exclusively induces WAKL4 accumulation by promoting WAKL4 transcription and blocking its vacuole-dependent proteolysis in roots. The accumulated WAKL4 next interacts with and phosphorylates the Cd transporter NRAMP1 at Tyr488, leading to the enhanced ubiquitination and vacuole-dependent degradation of NRAMP1, and consequently reducing Cd uptake. Our findings therefore uncover a mechanism conferred by the WAKL4-NRAMP1 module that enables plants to actively respond to Cd and limit its uptake, informing the future molecular breeding of low Cd accumulated crops or vegetables.

Suggested Citation

  • Jun Jie Yuan & Ya Nan Zhao & Su Hang Yu & Ying Sun & Gui Xin Li & Jing Ying Yan & Ji Ming Xu & Wo Na Ding & Moussa Benhamed & Rong Liang Qiu & Chong Wei Jin & Shao Jian Zheng & Zhong Jie Ding, 2024. "The Arabidopsis receptor-like kinase WAKL4 limits cadmium uptake via phosphorylation and degradation of NRAMP1 transporter," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53898-8
    DOI: 10.1038/s41467-024-53898-8
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    References listed on IDEAS

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    1. Shan Li & Yonghang Tian & Kun Wu & Yafeng Ye & Jianping Yu & Jianqing Zhang & Qian Liu & Mengyun Hu & Hui Li & Yiping Tong & Nicholas P. Harberd & Xiangdong Fu, 2018. "Modulating plant growth–metabolism coordination for sustainable agriculture," Nature, Nature, vol. 560(7720), pages 595-600, August.
    2. Zhijia Yang & Chongwu Wang & Yuan Xue & Xiao Liu & She Chen & ChunPeng Song & Yongqing Yang & Yan Guo, 2019. "Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    3. Keiichirou Nemoto & Abdelaziz Ramadan & Gen-ichiro Arimura & Kenichiro Imai & Kentaro Tomii & Kazuo Shinozaki & Tatsuya Sawasaki, 2017. "Tyrosine phosphorylation of the GARU E3 ubiquitin ligase promotes gibberellin signalling by preventing GID1 degradation," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
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