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Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance

Author

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  • Zhijia Yang

    (China Agricultural University)

  • Chongwu Wang

    (China Agricultural University)

  • Yuan Xue

    (China Agricultural University)

  • Xiao Liu

    (China Agricultural University)

  • She Chen

    (National Institute of Biological Sciences, Beijing)

  • ChunPeng Song

    (Henan University)

  • Yongqing Yang

    (China Agricultural University)

  • Yan Guo

    (China Agricultural University)

Abstract

Calcium is a universal secondary messenger that triggers many cellular responses. However, it is unclear how a calcium signal is coordinately decoded by different calcium sensors, which in turn regulate downstream targets to fulfill a specific physiological function. Here we show that SOS2-LIKE PROTEIN KINASE5 (PKS5) can negatively regulate the Salt-Overly-Sensitive signaling pathway in Arabidopsis. PKS5 can interact with and phosphorylate SOS2 at Ser294, promote the interaction between SOS2 and 14-3-3 proteins, and repress SOS2 activity. However, salt stress promotes an interaction between 14-3-3 proteins and PKS5, repressing its kinase activity and releasing inhibition of SOS2. We provide evidence that 14-3-3 proteins bind to Ca2+, and that Ca2+ modulates 14-3-3-dependent regulation of SOS2 and PKS5 kinase activity. Our results suggest that a salt-induced calcium signal is decoded by 14-3-3 and SOS3/SCaBP8 proteins, which selectively activate/inactivate the downstream protein kinases SOS2 and PKS5 to regulate Na+ homeostasis by coordinately mediating plasma membrane Na+/H+ antiporter and H+-ATPase activity.

Suggested Citation

  • Zhijia Yang & Chongwu Wang & Yuan Xue & Xiao Liu & She Chen & ChunPeng Song & Yongqing Yang & Yan Guo, 2019. "Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09181-2
    DOI: 10.1038/s41467-019-09181-2
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    Cited by:

    1. Muhammad Naveed & Haroon Sajid & Adnan Mustafa & Bushra Niamat & Zulfiqar Ahmad & Muhammad Yaseen & Muhammad Kamran & Munazza Rafique & Sunny Ahmar & Jen-Tsung Chen, 2020. "Alleviation of Salinity-Induced Oxidative Stress, Improvement in Growth, Physiology and Mineral Nutrition of Canola ( Brassica napus L.) through Calcium-Fortified Composted Animal Manure," Sustainability, MDPI, vol. 12(3), pages 1-17, January.
    2. Muhammad Ahsan & Hira Zulfiqar & Muhammad Ansar Farooq & Sajjad Ali & Aasma Tufail & Shamsa Kanwal & Muhammad Rashid Shaheen & Mateen Sajid & Hera Gul & Aftab Jamal & Muhammad Farhan Saeed & Roberto M, 2022. "Strigolactone (GR24) Application Positively Regulates Photosynthetic Attributes, Stress-Related Metabolites and Antioxidant Enzymatic Activities of Ornamental Sunflower ( Helianthus annuus cv. Vincent," Agriculture, MDPI, vol. 13(1), pages 1-17, December.

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