IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53816-y.html
   My bibliography  Save this article

From emergence to endemicity of highly pathogenic H5 avian influenza viruses in Taiwan

Author

Listed:
  • Yao-Tsun Li

    (University of Glasgow)

  • Hui-Ying Ko

    (Academia Sinica)

  • Joseph Hughes

    (MRC-University of Glasgow Centre for Virus Research)

  • Ming-Tsan Liu

    (Ministry of Health and Welfare)

  • Yi-Ling Lin

    (Academia Sinica
    Academia Sinica)

  • Katie Hampson

    (University of Glasgow)

  • Kirstyn Brunker

    (University of Glasgow
    MRC-University of Glasgow Centre for Virus Research)

Abstract

A/goose/Guangdong/1/96-like (GsGd) highly pathogenic avian influenza (HPAI) H5 viruses cause severe outbreaks in poultry when introduced. Since emergence in 1996, control measures in most countries have suppressed local GsGd transmission following introductions, making persistent transmission in domestic birds rare. However, geographical expansion of clade 2.3.4.4 sublineages has raised concern about establishment of endemic circulation, while mechanistic drivers leading to endemicity remain unknown. We reconstructed the evolutionary history of GsGd sublineage, clade 2.3.4.4c, in Taiwan using a time-heterogeneous rate phylogeographic model. During Taiwan’s initial epidemic wave (January 2015 - August 2016), we inferred that localised outbreaks had multiple origins from rapid spread between counties/cities nationwide. Subsequently, outbreaks predominantly originated from a single county, Yunlin, where persistent transmission harbours the trunk viruses of the sublineage. Endemic hotspots determined by phylogeographic reconstruction largely predicted the locations of re-emerging outbreaks in Yunlin. The transition to endemicity involved a shift to chicken-dominant circulation, following the initial bidirectional spread between chicken and domestic waterfowl. Our results suggest that following their emergence in Taiwan, source-sink dynamics from a single county have maintained GsGd endemicity up until 2023, pointing to where control efforts should be targeted to eliminate the disease.

Suggested Citation

  • Yao-Tsun Li & Hui-Ying Ko & Joseph Hughes & Ming-Tsan Liu & Yi-Ling Lin & Katie Hampson & Kirstyn Brunker, 2024. "From emergence to endemicity of highly pathogenic H5 avian influenza viruses in Taiwan," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53816-y
    DOI: 10.1038/s41467-024-53816-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53816-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-53816-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Gytis Dudas & Luiz Max Carvalho & Trevor Bedford & Andrew J. Tatem & Guy Baele & Nuno R. Faria & Daniel J. Park & Jason T. Ladner & Armando Arias & Danny Asogun & Filip Bielejec & Sarah L. Caddy & Mat, 2017. "Virus genomes reveal factors that spread and sustained the Ebola epidemic," Nature, Nature, vol. 544(7650), pages 309-315, April.
    2. Alexei J Drummond & Simon Y W Ho & Matthew J Phillips & Andrew Rambaut, 2006. "Relaxed Phylogenetics and Dating with Confidence," PLOS Biology, Public Library of Science, vol. 4(5), pages 1-1, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yankuo Sun & Jiabao Xing & Samuel L. Hong & Nena Bollen & Sijia Xu & Yue Li & Jianhao Zhong & Xiaopeng Gao & Dihua Zhu & Jing Liu & Lang Gong & Lei Zhou & Tongqing An & Mang Shi & Heng Wang & Guy Bael, 2024. "Untangling lineage introductions, persistence and transmission drivers of HP-PRRSV sublineage 8.7," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Jonathon D. Gass & Nichola J. Hill & Lambodhar Damodaran & Elena N. Naumova & Felicia B. Nutter & Jonathan A. Runstadler, 2023. "Ecogeographic Drivers of the Spatial Spread of Highly Pathogenic Avian Influenza Outbreaks in Europe and the United States, 2016–Early 2022," IJERPH, MDPI, vol. 20(11), pages 1-17, June.
    3. Joachim Schmidt & Lars Opgenoorth & Steffen Höll & Ralf Bastrop, 2012. "Into the Himalayan Exile: The Phylogeography of the Ground Beetle Ethira clade Supports the Tibetan Origin of Forest-Dwelling Himalayan Species Groups," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-15, September.
    4. Iliana Bista & Jonathan M. D. Wood & Thomas Desvignes & Shane A. McCarthy & Michael Matschiner & Zemin Ning & Alan Tracey & James Torrance & Ying Sims & William Chow & Michelle Smith & Karen Oliver & , 2023. "Genomics of cold adaptations in the Antarctic notothenioid fish radiation," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Haitao Shang & Daniel H. Rothman & Gregory P. Fournier, 2022. "Oxidative metabolisms catalyzed Earth’s oxygenation," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    6. Mekala Sundaram & Janna R Willoughby & Nathanael I Lichti & Michael A Steele & Robert K Swihart, 2015. "Segregating the Effects of Seed Traits and Common Ancestry of Hardwood Trees on Eastern Gray Squirrel Foraging Decisions," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    7. Nico Neureiter & Peter Ranacher & Nour Efrat-Kowalsky & Gereon A. Kaiping & Robert Weibel & Paul Widmer & Remco R. Bouckaert, 2022. "Detecting contact in language trees: a Bayesian phylogenetic model with horizontal transfer," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-14, December.
    8. Michael D Nowak & Andrew B Smith & Carl Simpson & Derrick J Zwickl, 2013. "A Simple Method for Estimating Informative Node Age Priors for the Fossil Calibration of Molecular Divergence Time Analyses," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-13, June.
    9. Bethany L Dearlove & Simon D W Frost, 2015. "Measuring Asymmetry in Time-Stamped Phylogenies," PLOS Computational Biology, Public Library of Science, vol. 11(7), pages 1-16, July.
    10. Hoan X. Dinh & Davinder Singh & Diana Gomez de la Cruz & Goetz Hensel & Jochen Kumlehn & Martin Mascher & Nils Stein & Dragan Perovic & Michael Ayliffe & Matthew J. Moscou & Robert F. Park & Mohammad , 2022. "The barley leaf rust resistance gene Rph3 encodes a predicted membrane protein and is induced upon infection by avirulent pathotypes of Puccinia hordei," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    11. Idrissa Nonmon Sanogo & Claire Guinat & Simon Dellicour & Mohamed Adama Diakité & Mamadou Niang & Ousmane A Koita & Christelle Camus & Mariette Ducatez, 2024. "Genetic insights of H9N2 avian influenza viruses circulating in Mali and phylogeographic patterns in Northern and Western Africa," Post-Print hal-04498485, HAL.
    12. Matheus Pontes-Nogueira & Marcio Martins & Laura R V Alencar & Ricardo J Sawaya, 2021. "The role of vicariance and dispersal on the temporal range dynamics of forest vipers in the Neotropical region," PLOS ONE, Public Library of Science, vol. 16(9), pages 1-18, September.
    13. Cristian R Altaba, 2009. "Universal Artifacts Affect the Branching of Phylogenetic Trees, Not Universal Scaling Laws," PLOS ONE, Public Library of Science, vol. 4(2), pages 1-13, February.
    14. Jessica E. Stockdale & Kurnia Susvitasari & Paul Tupper & Benjamin Sobkowiak & Nicola Mulberry & Anders Gonçalves da Silva & Anne E. Watt & Norelle L. Sherry & Corinna Minko & Benjamin P. Howden & Cou, 2023. "Genomic epidemiology offers high resolution estimates of serial intervals for COVID-19," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    15. Rebecca L. Kordas & Samraat Pawar & Dimitrios-Georgios Kontopoulos & Guy Woodward & Eoin J. O’Gorman, 2022. "Metabolic plasticity can amplify ecosystem responses to global warming," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    16. Lokman Galal & Frédéric Ariey & Meriadeg Ar Gouilh & Marie-Laure Dardé & Azra Hamidović & Franck Letourneur & Franck Prugnolle & Aurélien Mercier, 2022. "A unique Toxoplasma gondii haplotype accompanied the global expansion of cats," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    17. Matthew Hall & Mark Woolhouse & Andrew Rambaut, 2015. "Epidemic Reconstruction in a Phylogenetics Framework: Transmission Trees as Partitions of the Node Set," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-36, December.
    18. Joanne S. Boden & Juntao Zhong & Rika E. Anderson & Eva E. Stüeken, 2024. "Timing the evolution of phosphorus-cycling enzymes through geological time using phylogenomics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    19. Dinesh Aggarwal & Ben Warne & Aminu S. Jahun & William L. Hamilton & Thomas Fieldman & Louis Plessis & Verity Hill & Beth Blane & Emmeline Watkins & Elizabeth Wright & Grant Hall & Catherine Ludden & , 2022. "Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    20. Nan Song & Ai-Ping Liang, 2013. "A Preliminary Molecular Phylogeny of Planthoppers (Hemiptera: Fulgoroidea) Based on Nuclear and Mitochondrial DNA Sequences," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-11, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53816-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.