IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-53771-8.html
   My bibliography  Save this article

Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment

Author

Listed:
  • Bowen Li

    (4 Engineering Drive 4)

  • Jianwu Tian

    (4 Engineering Drive 4)

  • Fu Zhang

    (Zhejiang University)

  • Chongzhi Wu

    (Zhejiang University)

  • Zhiyao Li

    (Zhejiang University)

  • Dandan Wang

    (4 Engineering Drive 4)

  • Jiahao Zhuang

    (4 Engineering Drive 4)

  • Siqin Chen

    (4 Engineering Drive 4)

  • Wentao Song

    (4 Engineering Drive 4)

  • Yufu Tang

    (4 Engineering Drive 4)

  • Yuan Ping

    (Zhejiang University)

  • Bin Liu

    (4 Engineering Drive 4)

Abstract

Cancer stem cells, characterized by high tumorigenicity and drug-resistance, are often responsible for tumor progression and metastasis. Aldehyde dehydrogenases, often overexpressed in cancer stem cells enriched tumors, present a potential target for specific anti-cancer stem cells treatment. In this study, we report a self-assembled nano-prodrug composed of aldehyde dehydrogenases activatable photosensitizer and disulfide-linked all-trans retinoic acid for diagnosis and targeted treatment of cancer stem cells enriched tumors. The disulfide-linked all-trans retinoic acid can load with photosensitizer and self-assemble into a stable nano-prodrug, which can be disassembled into all-trans retinoic acid and photosensitizer in cancer stem cells by high level of glutathione. As for the released photosensitizer, overexpressed aldehyde dehydrogenase catalyzes the oxidation of aldehydes to carboxyl under cancer stem cells enriched microenvironment, activating the generation of reactive oxygen species and fluorescence emission. This generation of reactive oxygen species leads to direct killing of cancer stem cells and is accompanied by a noticeable fluorescence enhancement for real-time monitoring of the cancer stem cells enriched microenvironment. Moreover, the released all-trans retinoic acid, as a differentiation agent, reduce the cancer stem cells stemness and improve the cancer stem cells enriched microenvironment, offering a synergistic effect for enhanced anti-cancer stem cells treatment of photosensitizer in inhibition of in vivo tumor growth and metastasis.

Suggested Citation

  • Bowen Li & Jianwu Tian & Fu Zhang & Chongzhi Wu & Zhiyao Li & Dandan Wang & Jiahao Zhuang & Siqin Chen & Wentao Song & Yufu Tang & Yuan Ping & Bin Liu, 2024. "Self-assembled aldehyde dehydrogenase-activatable nano-prodrug for cancer stem cell-enriched tumor detection and treatment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53771-8
    DOI: 10.1038/s41467-024-53771-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-53771-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-53771-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Bingjun Sun & Cong Luo & Xuanbo Zhang & Mengran Guo & Mengchi Sun & Han Yu & Qin Chen & Wenqian Yang & Menglin Wang & Shiyi Zuo & Pengyu Chen & Qiming Kan & Haotian Zhang & Yongjun Wang & Zhonggui He , 2019. "Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    2. Jing An & Shanliang Tang & Gaobo Hong & Wenlong Chen & Miaomiao Chen & Jitao Song & Zhiliang Li & Xiaojun Peng & Fengling Song & Wen-Heng Zheng, 2022. "An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Corbin E. Meacham & Sean J. Morrison, 2013. "Tumour heterogeneity and cancer cell plasticity," Nature, Nature, vol. 501(7467), pages 328-337, September.
    4. Yingchao Chen & Tao Xiong & Qiang Peng & Jianjun Du & Wen Sun & Jiangli Fan & Xiaojun Peng, 2024. "Self-reporting photodynamic nanobody conjugate for precise and sustainable large-volume tumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Remy Elbez & Jeff Folz & Alan McLean & Hernan Roca & Joseph M Labuz & Kenneth J Pienta & Shuichi Takayama & Raoul Kopelman, 2021. "Cell-morphodynamic phenotype classification with application to cancer metastasis using cell magnetorotation and machine-learning," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-14, November.
    2. Humberto Contreras-Trujillo & Jiya Eerdeng & Samir Akre & Du Jiang & Jorge Contreras & Basia Gala & Mary C. Vergel-Rodriguez & Yeachan Lee & Aparna Jorapur & Areen Andreasian & Lisa Harton & Charles S, 2021. "Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    3. Seong Eun Lee & Seongyeol Park & Shinae Yi & Na Rae Choi & Mi Ae Lim & Jae Won Chang & Ho-Ryun Won & Je Ryong Kim & Hye Mi Ko & Eun-Jae Chung & Young Joo Park & Sun Wook Cho & Hyeong Won Yu & June You, 2024. "Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Haralampos Hatzikirou & Nikos I. Kavallaris & Marta Leocata, 2021. "A Novel Averaging Principle Provides Insights in the Impact of Intratumoral Heterogeneity on Tumor Progression," Mathematics, MDPI, vol. 9(20), pages 1-27, October.
    5. Jiahao Zhuang & Guobin Qi & Yecheng Feng & Min Wu & Hang Zhang & Dandan Wang & Xianhe Zhang & Kok Chan Chong & Bowen Li & Shitai Liu & Jianwu Tian & Yi Shan & Duo Mao & Bin Liu, 2024. "Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    6. Albert H Gough & Ning Chen & Tong Ying Shun & Timothy R Lezon & Robert C Boltz & Celeste E Reese & Jacob Wagner & Lawrence A Vernetti & Jennifer R Grandis & Adrian V Lee & Andrew M Stern & Mark E Schu, 2014. "Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-16, July.
    7. Yanying Wang & Jing Wang & Xiaoyu Li & Xushen Xiong & Jianyi Wang & Ziheng Zhou & Xiaoxiao Zhu & Yang Gu & Dan Dominissini & Lei He & Yong Tian & Chengqi Yi & Zusen Fan, 2021. "N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    8. Miranda V. Hunter & Reuben Moncada & Joshua M. Weiss & Itai Yanai & Richard M. White, 2021. "Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    9. Tian Liu & Lingxiao Li & Shuo Wang & Fudan Dong & Shiyi Zuo & Jiaxuan Song & Xin Wang & Qi Lu & Helin Wang & Haotian Zhang & Maosheng Cheng & Xiaohong Liu & Zhonggui He & Bingjun Sun & Jin Sun, 2022. "Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    11. Wenping Zhu & Ying Li & Shaoxun Guo & Wu-Jie Guo & Tuokai Peng & Hui Li & Bin Liu & Hui-Qing Peng & Ben Zhong Tang, 2022. "Stereoisomeric engineering of aggregation-induced emission photosensitizers towards fungal killing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    12. Josefine Radke & Elisa Schumann & Julia Onken & Randi Koll & Güliz Acker & Bohdan Bodnar & Carolin Senger & Sascha Tierling & Markus Möbs & Peter Vajkoczy & Anna Vidal & Sandra Högler & Petra Kodajova, 2022. "Decoding molecular programs in melanoma brain metastases," Nature Communications, Nature, vol. 13(1), pages 1-24, December.
    13. Claudia Bühnemann & Simon Li & Haiyue Yu & Harriet Branford White & Karl L Schäfer & Antonio Llombart-Bosch & Isidro Machado & Piero Picci & Pancras C W Hogendoorn & Nicholas A Athanasou & J Alison No, 2014. "Quantification of the Heterogeneity of Prognostic Cellular Biomarkers in Ewing Sarcoma Using Automated Image and Random Survival Forest Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-14, September.
    14. Jacob C Kimmel & Amy Y Chang & Andrew S Brack & Wallace F Marshall, 2018. "Inferring cell state by quantitative motility analysis reveals a dynamic state system and broken detailed balance," PLOS Computational Biology, Public Library of Science, vol. 14(1), pages 1-29, January.
    15. Songlei Zhou & Yukun Huang & Yu Chen & Yipu Liu & Laozhi Xie & Yang You & Shiqiang Tong & Jianpei Xu & Gan Jiang & Qingxiang Song & Ni Mei & Fenfen Ma & Xiaoling Gao & Hongzhuan Chen & Jun Chen, 2023. "Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    16. Kun-Xu Teng & Li-Ya Niu & Nan Xie & Qing-Zheng Yang, 2022. "Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    17. Zhao Zhang & Zixiang Wei & Jintong Guo & Jinxiao Lyu & Bingzhe Wang & Gang Wang & Chunfei Wang & Liqiang Zhou & Zhen Yuan & Guichuan Xing & Changfeng Wu & Xuanjun Zhang, 2024. "Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    18. Jing Gao & Xingyu Jiang & Shumin Lei & Wenhao Cheng & Yi Lai & Min Li & Lei Yang & Peifeng Liu & Xiao-hua Chen & Min Huang & Haijun Yu & Huixiong Xu & Zhiai Xu, 2024. "A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    19. Zijuan Li & Yuyun Zhang & Ci-Hang Ding & Yan Chen & Haoyu Wang & Jinyu Zhang & Songbei Ying & Meiyue Wang & Rongzhi Zhang & Jinyi Liu & Yilin Xie & Tengfei Tang & Huishan Diao & Luhuan Ye & Yili Zhuan, 2023. "LHP1-mediated epigenetic buffering of subgenome diversity and defense responses confers genome plasticity and adaptability in allopolyploid wheat," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    20. Yang Gu & Zhibin Yi & Ziheng Zhou & Jianyi Wang & Shan Li & Pingping Zhu & Nian Liu & Yuwei Xu & Lei He & Yanying Wang & Zusen Fan, 2024. "SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53771-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.