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Chromatic covalent organic frameworks enabling in-vivo chemical tomography

Author

Listed:
  • Song Wang

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Yangyang Han

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Vaishnavi Amarr Reddy

    (Temasek Life Sciences Laboratory Limited)

  • Mervin Chun-Yi Ang

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Gabriel Sánchez-Velázquez

    (Massachusetts Institute of Technology)

  • Jolly Madathiparambil Saju

    (Temasek Life Sciences Laboratory Limited)

  • Yunteng Cao

    (Massachusetts Institute of Technology)

  • Duc Thinh Khong

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Praveen Kumar Jayapal

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Raju Cheerlavancha

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Suh In Loh

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Gajendra Pratap Singh

    (Singapore-MIT Alliance for Research and Technology Centre)

  • Daisuke Urano

    (Temasek Life Sciences Laboratory Limited)

  • Sarojam Rajani

    (Temasek Life Sciences Laboratory Limited)

  • Benedetto Marelli

    (Singapore-MIT Alliance for Research and Technology Centre
    Massachusetts Institute of Technology)

  • Michael S. Strano

    (Singapore-MIT Alliance for Research and Technology Centre
    Massachusetts Institute of Technology)

Abstract

Covalent organic frameworks designed as chromatic sensors offer opportunities to probe biological interfaces, particularly when combined with biocompatible matrices. Particularly compelling is the prospect of chemical tomography – or the 3D spatial mapping of chemical detail within the complex environment of living systems. Herein, we demonstrate a chromic Covalent Organic Framework (COF) integrated within silk fibroin (SF) microneedles that probe plant vasculature, sense the alkalization of vascular fluid as a biomarker for drought stress, and provide a 3D in-vivo mapping of chemical gradients using smartphone technology. A series of Schiff base COFs with tunable pKa ranging from 5.6 to 7.6 enable conical, optically transparent SF microneedles with COF coatings of 120 to 950 nm to probe vascular fluid and the surrounding tissues of tobacco and tomato plants. The conical design allows for 3D mapping of the chemical environment (such as pH) at standoff distances from the plant, enabling in-vivo chemical tomography. Chromatic COF sensors of this type will enable multidimensional chemical mapping of previously inaccessible and complex environments.

Suggested Citation

  • Song Wang & Yangyang Han & Vaishnavi Amarr Reddy & Mervin Chun-Yi Ang & Gabriel Sánchez-Velázquez & Jolly Madathiparambil Saju & Yunteng Cao & Duc Thinh Khong & Praveen Kumar Jayapal & Raju Cheerlavan, 2024. "Chromatic covalent organic frameworks enabling in-vivo chemical tomography," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53532-7
    DOI: 10.1038/s41467-024-53532-7
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    References listed on IDEAS

    as
    1. Laura Ascherl & Emrys W. Evans & Matthias Hennemann & Daniele Di Nuzzo & Alexander G. Hufnagel & Michael Beetz & Richard H. Friend & Timothy Clark & Thomas Bein & Florian Auras, 2018. "Solvatochromic covalent organic frameworks," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    2. Ranjit Kulkarni & Yu Noda & Deepak Kumar Barange & Yaroslav S. Kochergin & Pengbo Lyu & Barbora Balcarova & Petr Nachtigall & Michael J. Bojdys, 2019. "Real-time optical and electronic sensing with a β-amino enone linked, triazine-containing 2D covalent organic framework," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
    Full references (including those not matched with items on IDEAS)

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