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A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy

Author

Listed:
  • Chao Liang

    (Shenzhen University
    Shenzhen University
    Hanshan Normal University)

  • Jiaen Xie

    (Shenzhen University)

  • Shuangling Luo

    (Shenzhen University)

  • Can Huang

    (Sun Yat-sen University)

  • Qianling Zhang

    (Shenzhen University)

  • Huaiyi Huang

    (Sun Yat-sen University)

  • Pingyu Zhang

    (Shenzhen University)

Abstract

As a basic structure of most polypyridinal metal complexes, [Ru(bpy)3]2+, has the advantages of simple structure, facile synthesis and high yield, which has great potential for scientific research and application. However, sonodynamic therapy (SDT) performance of [Ru(bpy)3]2+ has not been investigated so far. SDT can overcome the tissue-penetration and phototoxicity problems compared to photodynamic therapy. Here, we report that [Ru(bpy)3]2+ is a highly potent sonosensitizer and sonocatalyst for sonotherapy in vitro and in vivo. [Ru(bpy)3]2+ can produce singlet oxygen (1O2) and sono-oxidize endogenous 1,4-dihydronicotinamide adenine dinucleotide (NADH) under ultrasound (US) stimulation in cancer cells. Furthermore, [Ru(bpy)3]2+ enables effective destruction of mice tumors, and the therapeutic effect can reach deep tissues over 10 cm under US irradiation. This work paves a way for polypyridinal metal complexes to be applied to the noninvasive precise sonotherapy of cancer.

Suggested Citation

  • Chao Liang & Jiaen Xie & Shuangling Luo & Can Huang & Qianling Zhang & Huaiyi Huang & Pingyu Zhang, 2021. "A highly potent ruthenium(II)-sonosensitizer and sonocatalyst for in vivo sonotherapy," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25303-1
    DOI: 10.1038/s41467-021-25303-1
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    Cited by:

    1. Ding Wen & Jing Feng & Ruiping Deng & Kai Li & Hongjie Zhang, 2024. "Zn/Pt dual-site single-atom driven difunctional superimposition-augmented sonosensitizer for sonodynamic therapy boosted ferroptosis of cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Nong Lu & Zhihong Deng & Jing Gao & Chao Liang & Haiping Xia & Pingyu Zhang, 2022. "An osmium-peroxo complex for photoactive therapy of hypoxic tumors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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