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Interference length reveals regularity of crossover placement across species

Author

Listed:
  • Marcel Ernst

    (Max Planck Institute for Dynamics and Self-Organization
    Institute for the Dynamics of Complex Systems)

  • Raphael Mercier

    (Max Planck Institute for Plant Breeding Research)

  • David Zwicker

    (Max Planck Institute for Dynamics and Self-Organization)

Abstract

Crossover interference is a phenomenon that affects the number and positioning of crossovers in meiosis and thus affects genetic diversity and chromosome segregation. Yet, the underlying mechanism is not fully understood, partly because quantification is difficult. To overcome this challenge, we introduce the interference length Lint that quantifies changes in crossover patterning due to interference. We show that it faithfully captures known aspects of crossover interference and provides superior statistical power over previous measures such as the interference distance and the gamma shape parameter. We apply our analysis to empirical data and unveil a similar behavior of Lint across species, which hints at a common mechanism. A recently proposed coarsening model generally captures these aspects, providing a unified view of crossover interference. Consequently, Lint facilitates model refinements and general comparisons between alternative models of crossover interference.

Suggested Citation

  • Marcel Ernst & Raphael Mercier & David Zwicker, 2024. "Interference length reveals regularity of crossover placement across species," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53054-2
    DOI: 10.1038/s41467-024-53054-2
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    References listed on IDEAS

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    1. Stéphanie Durand & Qichao Lian & Juli Jing & Marcel Ernst & Mathilde Grelon & David Zwicker & Raphael Mercier, 2022. "Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Eugenio Mancera & Richard Bourgon & Alessandro Brozzi & Wolfgang Huber & Lars M. Steinmetz, 2008. "High-resolution mapping of meiotic crossovers and non-crossovers in yeast," Nature, Nature, vol. 454(7203), pages 479-485, July.
    3. Liangran Zhang & Shunxin Wang & Shen Yin & Soogil Hong & Keun P. Kim & Nancy Kleckner, 2014. "Topoisomerase II mediates meiotic crossover interference," Nature, Nature, vol. 511(7511), pages 551-556, July.
    4. Chris Morgan & John A. Fozard & Matthew Hartley & Ian R. Henderson & Kirsten Bomblies & Martin Howard, 2021. "Diffusion-mediated HEI10 coarsening can explain meiotic crossover positioning in Arabidopsis," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    5. Avery Davis Bell & Curtis J. Mello & James Nemesh & Sara A. Brumbaugh & Alec Wysoker & Steven A. McCarroll, 2020. "Insights into variation in meiosis from 31,228 human sperm genomes," Nature, Nature, vol. 583(7815), pages 259-264, July.
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