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Aborting meiosis allows recombination in sterile diploid yeast hybrids

Author

Listed:
  • Simone Mozzachiodi

    (Université Côte d’Azur, CNRS, INSERM, IRCAN
    Meiogenix, 38, rue Servan)

  • Lorenzo Tattini

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Agnes Llored

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Agurtzane Irizar

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Neža Škofljanc

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Melania D’Angiolo

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Matteo De Chiara

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Benjamin P. Barré

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Jia-Xing Yue

    (Université Côte d’Azur, CNRS, INSERM, IRCAN
    Sun Yat-sen University Cancer Center)

  • Angela Lutazi

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

  • Sophie Loeillet

    (Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University)

  • Raphaelle Laureau

    (Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University
    Hammer Health Sciences Center, Columbia University Medical Center)

  • Souhir Marsit

    (Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University
    SPO, Université Montpellier, INRAE, Montpellier SupAgro
    Université du Québec à Rimouski, Rimouski)

  • Simon Stenberg

    (University of Gothenburg)

  • Benoit Albaud

    (Institut Curie, ICGEX NGS Platform)

  • Karl Persson

    (University of Gothenburg)

  • Jean-Luc Legras

    (SPO, Université Montpellier, INRAE, Montpellier SupAgro)

  • Sylvie Dequin

    (SPO, Université Montpellier, INRAE, Montpellier SupAgro)

  • Jonas Warringer

    (University of Gothenburg)

  • Alain Nicolas

    (Université Côte d’Azur, CNRS, INSERM, IRCAN
    Meiogenix, 38, rue Servan
    Institut Curie, Centre de Recherche, CNRS-UMR3244, PSL Research University)

  • Gianni Liti

    (Université Côte d’Azur, CNRS, INSERM, IRCAN)

Abstract

Hybrids between diverged lineages contain novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explore to what extent an aborted meiosis followed by a return-to-growth (RTG) promotes recombination across a panel of 20 Saccharomyces cerevisiae and S. paradoxus diploid hybrids with different genomic structures and levels of sterility. Genome analyses of 275 clones reveal that RTG promotes recombination and generates extensive regions of loss-of-heterozygosity in sterile hybrids with either a defective meiosis or a heavily rearranged karyotype, whereas RTG recombination is reduced by high sequence divergence between parental subgenomes. The RTG recombination preferentially arises in regions with low local heterozygosity and near meiotic recombination hotspots. The loss-of-heterozygosity has a profound impact on sexual and asexual fitness, and enables genetic mapping of phenotypic differences in sterile lineages where linkage analysis would fail. We propose that RTG gives sterile yeast hybrids access to a natural route for genome recombination and adaptation.

Suggested Citation

  • Simone Mozzachiodi & Lorenzo Tattini & Agnes Llored & Agurtzane Irizar & Neža Škofljanc & Melania D’Angiolo & Matteo De Chiara & Benjamin P. Barré & Jia-Xing Yue & Angela Lutazi & Sophie Loeillet & Ra, 2021. "Aborting meiosis allows recombination in sterile diploid yeast hybrids," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26883-8
    DOI: 10.1038/s41467-021-26883-8
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    1. Simone Mozzachiodi & Kristoffer Krogerus & Brian Gibson & Alain Nicolas & Gianni Liti, 2022. "Unlocking the functional potential of polyploid yeasts," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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