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Topoisomerase II mediates meiotic crossover interference

Author

Listed:
  • Liangran Zhang

    (Harvard University)

  • Shunxin Wang

    (Harvard University)

  • Shen Yin

    (Harvard University)

  • Soogil Hong

    (Chung-Ang University, Seoul 156-756, South Korea)

  • Keun P. Kim

    (Chung-Ang University, Seoul 156-756, South Korea)

  • Nancy Kleckner

    (Harvard University)

Abstract

Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role, thus identifying a new function for this critical molecule. SUMOylation (of topoisomerase II and axis component Red1) and ubiquitin-mediated removal of SUMOylated proteins are also required. The findings support the hypothesis that crossover interference involves accumulation, relief and redistribution of mechanical stress along the protein/DNA meshwork of meiotic chromosome axes, with topoisomerase II required to adjust spatial relationships among DNA segments.

Suggested Citation

  • Liangran Zhang & Shunxin Wang & Shen Yin & Soogil Hong & Keun P. Kim & Nancy Kleckner, 2014. "Topoisomerase II mediates meiotic crossover interference," Nature, Nature, vol. 511(7511), pages 551-556, July.
    • Handle: RePEc:nat:nature:v:511:y:2014:i:7511:d:10.1038_nature13442
    DOI: 10.1038/nature13442
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    Cited by:

    1. Marcel Ernst & Raphael Mercier & David Zwicker, 2024. "Interference length reveals regularity of crossover placement across species," Nature Communications, Nature, vol. 15(1), pages 1-9, December.

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