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Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement

Author

Listed:
  • Sudiksha Sridhar

    (Boston University)

  • Eric Lowet

    (Boston University
    Erasmus MC)

  • Howard J. Gritton

    (Boston University
    University of Illinois at Urbana-Champaign)

  • Jennifer Freire

    (Boston University
    Boston University)

  • Chengqian Zhou

    (Boston University)

  • Florence Liang

    (Boston University)

  • Xue Han

    (Boston University)

Abstract

Stepping movement is delta (1–4 Hz) rhythmic and depends on sensory inputs. Stepping-related delta-rhythmic neural activity is coupled to beta (10–30 Hz) frequency dynamics that are also prominent in sensorimotor circuits. We explored how beta-frequency sensory stimulation influences stepping and dorsal striatal regulation of stepping. We delivered audiovisual stimulation at 10 or 145 Hz to mice voluntarily locomoting, while recording locomotion, cellular calcium dynamics and local field potentials (LFPs). We found that 10 Hz, but not 145 Hz stimulation prominently entrained striatal LFPs. Even though stimulation at both frequencies promoted locomotion and desynchronized striatal network, only 10 Hz stimulation enhanced the delta rhythmicity of stepping and strengthened the coupling between stepping and striatal LFP delta and beta oscillations. These results demonstrate that higher frequency sensory stimulation can modulate lower frequency striatal neural dynamics and improve stepping rhythmicity, highlighting the translational potential of non-invasive beta-frequency sensory stimulation for improving gait.

Suggested Citation

  • Sudiksha Sridhar & Eric Lowet & Howard J. Gritton & Jennifer Freire & Chengqian Zhou & Florence Liang & Xue Han, 2024. "Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52664-0
    DOI: 10.1038/s41467-024-52664-0
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    References listed on IDEAS

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