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Gain control by layer six in cortical circuits of vision

Author

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  • Shawn R. Olsen

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Dante S. Bortone

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Hillel Adesnik

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

  • Massimo Scanziani

    (Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, University of California San Diego)

Abstract

After entering the cerebral cortex, sensory information spreads through six different horizontal neuronal layers that are interconnected by vertical axonal projections. It is believed that through these projections layers can influence each other's response to sensory stimuli, but the specific role that each layer has in cortical processing is still poorly understood. Here we show that layer six in the primary visual cortex of the mouse has a crucial role in controlling the gain of visually evoked activity in neurons of the upper layers without changing their tuning to orientation. This gain modulation results from the coordinated action of layer six intracortical projections to superficial layers and deep projections to the thalamus, with a substantial role of the intracortical circuit. This study establishes layer six as a major mediator of cortical gain modulation and suggests that it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.

Suggested Citation

  • Shawn R. Olsen & Dante S. Bortone & Hillel Adesnik & Massimo Scanziani, 2012. "Gain control by layer six in cortical circuits of vision," Nature, Nature, vol. 483(7387), pages 47-52, March.
    • Handle: RePEc:nat:nature:v:483:y:2012:i:7387:d:10.1038_nature10835
    DOI: 10.1038/nature10835
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    Cited by:

    1. Longyu Ma & Lupeng Yue & Shuting Liu & Shi Xu & Jifu Tong & Xiaoyan Sun & Li Su & Shuang Cui & Feng-Yu Liu & You Wan & Ming Yi, 2024. "A distinct neuronal ensemble of prelimbic cortex mediates spontaneous pain in rats with peripheral inflammation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Yanjie Wang & Zhaonan Chen & Guofen Ma & Lizhao Wang & Yanmei Liu & Meiling Qin & Xiang Fei & Yifan Wu & Min Xu & Siyu Zhang, 2023. "A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Katharina Ziegler & Ross Folkard & Antonio J. Gonzalez & Jan Burghardt & Sailaja Antharvedi-Goda & Jesus Martin-Cortecero & Emilio Isaías-Camacho & Sanjeev Kaushalya & Linette Liqi Tan & Thomas Kuner , 2023. "Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Elaida D. Dimwamwa & Aurélie Pala & Vivek Chundru & Nathaniel C. Wright & Garrett B. Stanley, 2024. "Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Koun Onodera & Hiroyuki K. Kato, 2022. "Translaminar recurrence from layer 5 suppresses superficial cortical layers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Milad Hobbi Mobarhan & Geir Halnes & Pablo Martínez-Cañada & Torkel Hafting & Marianne Fyhn & Gaute T Einevoll, 2018. "Firing-rate based network modeling of the dLGN circuit: Effects of cortical feedback on spatiotemporal response properties of relay cells," PLOS Computational Biology, Public Library of Science, vol. 14(5), pages 1-38, May.

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