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The medial septum controls hippocampal supra-theta oscillations

Author

Listed:
  • Bálint Király

    (Institute of Experimental Medicine
    Eötvös Loránd University)

  • Andor Domonkos

    (Institute of Experimental Medicine)

  • Márta Jelitai

    (Institute of Experimental Medicine)

  • Vítor Lopes-dos-Santos

    (University of Oxford)

  • Sergio Martínez-Bellver

    (Institute of Experimental Medicine
    University of Valencia)

  • Barnabás Kocsis

    (Institute of Experimental Medicine
    Pázmány Péter Catholic University)

  • Dániel Schlingloff

    (Institute of Experimental Medicine)

  • Abhilasha Joshi

    (University of Oxford)

  • Minas Salib

    (University of Oxford)

  • Richárd Fiáth

    (Pázmány Péter Catholic University
    Research Centre for Natural Sciences)

  • Péter Barthó

    (Research Centre for Natural Sciences)

  • István Ulbert

    (Pázmány Péter Catholic University
    Research Centre for Natural Sciences)

  • Tamás F. Freund

    (Institute of Experimental Medicine)

  • Tim J. Viney

    (University of Oxford)

  • David Dupret

    (University of Oxford)

  • Viktor Varga

    (Institute of Experimental Medicine)

  • Balázs Hangya

    (Institute of Experimental Medicine)

Abstract

Hippocampal theta oscillations orchestrate faster beta-to-gamma oscillations facilitating the segmentation of neural representations during navigation and episodic memory. Supra-theta rhythms of hippocampal CA1 are coordinated by local interactions as well as inputs from the entorhinal cortex (EC) and CA3 inputs. However, theta-nested gamma-band activity in the medial septum (MS) suggests that the MS may control supra-theta CA1 oscillations. To address this, we performed multi-electrode recordings of MS and CA1 activity in rodents and found that MS neuron firing showed strong phase-coupling to theta-nested supra-theta episodes and predicted changes in CA1 beta-to-gamma oscillations on a cycle-by-cycle basis. Unique coupling patterns of anatomically defined MS cell types suggested that indirect MS-to-CA1 pathways via the EC and CA3 mediate distinct CA1 gamma-band oscillations. Optogenetic activation of MS parvalbumin-expressing neurons elicited theta-nested beta-to-gamma oscillations in CA1. Thus, the MS orchestrates hippocampal network activity at multiple temporal scales to mediate memory encoding and retrieval.

Suggested Citation

  • Bálint Király & Andor Domonkos & Márta Jelitai & Vítor Lopes-dos-Santos & Sergio Martínez-Bellver & Barnabás Kocsis & Dániel Schlingloff & Abhilasha Joshi & Minas Salib & Richárd Fiáth & Péter Barthó , 2023. "The medial septum controls hippocampal supra-theta oscillations," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41746-0
    DOI: 10.1038/s41467-023-41746-0
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    References listed on IDEAS

    as
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