Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-024-52174-z
Download full text from publisher
References listed on IDEAS
- Lulu Guo & Jie Cheng & Shuo Lian & Qun Liu & Yan Lu & Yuan Zheng & Kongkai Zhu & Minghui Zhang & Yalei Kong & Chao Zhang & Naikang Rong & Yuming Zhuang & Guoxing Fang & Jingjing Jiang & Tianyao Zhang , 2023. "Structural basis of amine odorant perception by a mammal olfactory receptor," Nature, Nature, vol. 618(7963), pages 193-200, June.
- Kathryn Tunyasuvunakool & Jonas Adler & Zachary Wu & Tim Green & Michal Zielinski & Augustin Žídek & Alex Bridgland & Andrew Cowie & Clemens Meyer & Agata Laydon & Sameer Velankar & Gerard J. Kleywegt, 2021. "Highly accurate protein structure prediction for the human proteome," Nature, Nature, vol. 596(7873), pages 590-596, August.
- Shifan Yang & Yiran Wu & Ting-Hai Xu & Parker W. Waal & Yuanzheng He & Mengchen Pu & Yuxiang Chen & Zachary J. DeBruine & Bingjie Zhang & Saheem A. Zaidi & Petr Popov & Yu Guo & Gye Won Han & Yang Lu , 2018. "Crystal structure of the Frizzled 4 receptor in a ligand-free state," Nature, Nature, vol. 560(7720), pages 666-670, August.
- Xiaofeng Qi & Heng Liu & Bonne Thompson & Jeffrey McDonald & Cheng Zhang & Xiaochun Li, 2019. "Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi," Nature, Nature, vol. 571(7764), pages 279-283, July.
- Na Wang & Xinheng He & Jing Zhao & Hualiang Jiang & Xi Cheng & Yu Xia & H. Eric Xu & Yuanzheng He, 2022. "Structural basis of leukotriene B4 receptor 1 activation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
- Xinyan Zhu & Yu Qian & Xiaowan Li & Zhenmei Xu & Ruixue Xia & Na Wang & Jiale Liang & Han Yin & Anqi Zhang & Changyou Guo & Guangfu Wang & Yuanzheng He, 2022. "Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Shane C. Wright & Paweł Kozielewicz & Maria Kowalski-Jahn & Julian Petersen & Carl-Fredrik Bowin & Greg Slodkowicz & Maria Marti-Solano & David Rodríguez & Belma Hot & Najeah Okashah & Katerina Strako, 2019. "A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
- G. Glenn Gregorio & Matthieu Masureel & Daniel Hilger & Daniel S. Terry & Manuel Juette & Hong Zhao & Zhou Zhou & Jose Manuel Perez-Aguilar & Maria Hauge & Signe Mathiasen & Jonathan A. Javitch & Hare, 2017. "Single-molecule analysis of ligand efficacy in β2AR–G-protein activation," Nature, Nature, vol. 547(7661), pages 68-73, July.
- Yang Lee & Tony Warne & Rony Nehmé & Shubhi Pandey & Hemlata Dwivedi-Agnihotri & Madhu Chaturvedi & Patricia C. Edwards & Javier García-Nafría & Andrew G. W. Leslie & Arun K. Shukla & Christopher G. T, 2020. "Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor," Nature, Nature, vol. 583(7818), pages 862-866, July.
- Alpay B. Seven & Ximena Barros-Álvarez & Marine Lapeyrière & Makaía M. Papasergi-Scott & Michael J. Robertson & Chensong Zhang & Robert M. Nwokonko & Yang Gao & Justin G. Meyerowitz & Jean-Philippe Ro, 2021. "G-protein activation by a metabotropic glutamate receptor," Nature, Nature, vol. 595(7867), pages 450-454, July.
- John Jumper & Richard Evans & Alexander Pritzel & Tim Green & Michael Figurnov & Olaf Ronneberger & Kathryn Tunyasuvunakool & Russ Bates & Augustin Žídek & Anna Potapenko & Alex Bridgland & Clemens Me, 2021. "Highly accurate protein structure prediction with AlphaFold," Nature, Nature, vol. 596(7873), pages 583-589, August.
- Chong Wang & Huixian Wu & Vsevolod Katritch & Gye Won Han & Xi-Ping Huang & Wei Liu & Fai Yiu Siu & Bryan L. Roth & Vadim Cherezov & Raymond C. Stevens, 2013. "Structure of the human smoothened receptor bound to an antitumour agent," Nature, Nature, vol. 497(7449), pages 338-343, May.
- Makaía M. Papasergi-Scott & Michael J. Robertson & Alpay B. Seven & Ouliana Panova & Jesper M. Mathiesen & Georgios Skiniotis, 2020. "Structures of metabotropic GABAB receptor," Nature, Nature, vol. 584(7820), pages 310-314, August.
- Peiyu Xu & Sijie Huang & Huibing Zhang & Chunyou Mao & X. Edward Zhou & Xi Cheng & Icaro A. Simon & Dan-Dan Shen & Hsin-Yung Yen & Carol V. Robinson & Kasper Harpsøe & Bo Svensson & Jia Guo & Hualiang, 2021. "Structural insights into the lipid and ligand regulation of serotonin receptors," Nature, Nature, vol. 592(7854), pages 469-473, April.
- Jia Duan & Heng Liu & Fenghui Zhao & Qingning Yuan & Yujie Ji & Xiaoqing Cai & Xinheng He & Xinzhu Li & Junrui Li & Kai Wu & Tianyu Gao & Shengnan Zhu & Shi Lin & Ming-Wei Wang & Xi Cheng & Wanchao Yi, 2023. "GPCR activation and GRK2 assembly by a biased intracellular agonist," Nature, Nature, vol. 620(7974), pages 676-681, August.
- Julian Petersen & Shane C. Wright & David Rodríguez & Pierre Matricon & Noa Lahav & Aviv Vromen & Assaf Friedler & Johan Strömqvist & Stefan Wennmalm & Jens Carlsson & Gunnar Schulte, 2017. "Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
- Jia Duan & Dan-dan Shen & X. Edward Zhou & Peng Bi & Qiu-feng Liu & Yang-xia Tan & You-wen Zhuang & Hui-bing Zhang & Pei-yu Xu & Si-Jie Huang & Shan-shan Ma & Xin-heng He & Karsten Melcher & Yan Zhang, 2020. "Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Jiale Liang & Asuka Inoue & Tatsuya Ikuta & Ruixue Xia & Na Wang & Kouki Kawakami & Zhenmei Xu & Yu Qian & Xinyan Zhu & Anqi Zhang & Changyou Guo & Zhiwei Huang & Yuanzheng He, 2023. "Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
- Hongmin Cai & Shimeng Guo & Youwei Xu & Jun Sun & Junrui Li & Zhikan Xia & Yi Jiang & Xin Xie & H. Eric Xu, 2024. "Cryo-EM structures of adenosine receptor A3AR bound to selective agonists," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
- Xuan Zhang & Yujing Wang & Shreyas Supekar & Xu Cao & Jingkai Zhou & Jessica Dang & Siqi Chen & Laura Jenkins & Sara Marsango & Xiu Li & Guibing Liu & Graeme Milligan & Mingye Feng & Hao Fan & Weimin , 2023. "Pro-phagocytic function and structural basis of GPR84 signaling," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Shota Suzuki & Kotaro Tanaka & Kouki Nishikawa & Hiroshi Suzuki & Atsunori Oshima & Yoshinori Fujiyoshi, 2023. "Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
- Na Wang & Xinheng He & Jing Zhao & Hualiang Jiang & Xi Cheng & Yu Xia & H. Eric Xu & Yuanzheng He, 2022. "Structural basis of leukotriene B4 receptor 1 activation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
- Kaihua Zhang & Hao Wu & Nicholas Hoppe & Aashish Manglik & Yifan Cheng, 2022. "Fusion protein strategies for cryo-EM study of G protein-coupled receptors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Xinyan Zhu & Yu Qian & Xiaowan Li & Zhenmei Xu & Ruixue Xia & Na Wang & Jiale Liang & Han Yin & Anqi Zhang & Changyou Guo & Guangfu Wang & Yuanzheng He, 2022. "Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Chunyou Mao & Mengru Gao & Shao-Kun Zang & Yanqing Zhu & Dan-Dan Shen & Li-Nan Chen & Liu Yang & Zhiwei Wang & Huibing Zhang & Wei-Wei Wang & Qingya Shen & Yanhui Lu & Xin Ma & Yan Zhang, 2023. "Orthosteric and allosteric modulation of human HCAR2 signaling complex," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
- Canrong Wu & Youwei Xu & Qian He & Dianrong Li & Jia Duan & Changyao Li & Chongzhao You & Han Chen & Weiliang Fan & Yi Jiang & H. Eric Xu, 2023. "Ligand-induced activation and G protein coupling of prostaglandin F2α receptor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Yujie Ji & Jia Duan & Qingning Yuan & Xinheng He & Gong Yang & Shengnan Zhu & Kai Wu & Wen Hu & Tianyu Gao & Xi Cheng & Hualiang Jiang & H. Eric Xu & Yi Jiang, 2023. "Structural basis of peptide recognition and activation of endothelin receptors," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
- Pengfei Yan & Xi Lin & Lijie Wu & Lu Xu & Fei Li & Junlin Liu & Fei Xu, 2024. "The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
- Ruixue Xia & Shuang Shi & Zhenmei Xu & Henry F. Vischer & Albert D. Windhorst & Yu Qian & Yaning Duan & Jiale Liang & Kai Chen & Anqi Zhang & Changyou Guo & Rob Leurs & Yuanzheng He, 2024. "Structural basis of ligand recognition and design of antihistamines targeting histamine H4 receptor," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
- Pierre Azoulay & Joshua Krieger & Abhishek Nagaraj, 2024.
"Old Moats for New Models: Openness, Control, and Competition in Generative AI,"
NBER Chapters, in: Entrepreneurship and Innovation Policy and the Economy, volume 4,
National Bureau of Economic Research, Inc.
- Pierre Azoulay & Joshua L. Krieger & Abhishek Nagaraj, 2024. "Old Moats for New Models: Openness, Control, and Competition in Generative AI," NBER Working Papers 32474, National Bureau of Economic Research, Inc.
- Deyun Qiu & Jinxin V. Pei & James E. O. Rosling & Vandana Thathy & Dongdi Li & Yi Xue & John D. Tanner & Jocelyn Sietsma Penington & Yi Tong Vincent Aw & Jessica Yi Han Aw & Guoyue Xu & Abhai K. Tripa, 2022. "A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
- Shuo-Shuo Liu & Tian-Xia Jiang & Fan Bu & Ji-Lan Zhao & Guang-Fei Wang & Guo-Heng Yang & Jie-Yan Kong & Yun-Fan Qie & Pei Wen & Li-Bin Fan & Ning-Ning Li & Ning Gao & Xiao-Bo Qiu, 2024. "Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Xiaoke Yang & Mingqi Zhu & Xue Lu & Yuxin Wang & Junyu Xiao, 2024. "Architecture and activation of human muscle phosphorylase kinase," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Efren Garcia-Maldonado & Andrew D. Huber & Sergio C. Chai & Stanley Nithianantham & Yongtao Li & Jing Wu & Shyaron Poudel & Darcie J. Miller & Jayaraman Seetharaman & Taosheng Chen, 2024. "Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Kristy Rochon & Brianna L. Bauer & Nathaniel A. Roethler & Yuli Buckley & Chih-Chia Su & Wei Huang & Rajesh Ramachandran & Maria S. K. Stoll & Edward W. Yu & Derek J. Taylor & Jason A. Mears, 2024. "Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
- Katherine A. Ray & Joshua D. Lutgens & Ramesh Bista & Jie Zhang & Ronak R. Desai & Melissa Hirsch & Takeshi Miyazawa & Antonio Cordova & Adrian T. Keatinge-Clay, 2024. "Assessing and harnessing updated polyketide synthase modules through combinatorial engineering," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
- Fan Lu & Liang Zhu & Thomas Bromberger & Jun Yang & Qiannan Yang & Jianmin Liu & Edward F. Plow & Markus Moser & Jun Qin, 2022. "Mechanism of integrin activation by talin and its cooperation with kindlin," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52174-z. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.