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Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution

Author

Listed:
  • Yingyi Huang

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Xiang Liu

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center
    BGI Research)

  • Shuo Li

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Chen Li

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Hong-Yan Wang

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Qun Liu

    (BGI Research
    BGI Research
    University of Copenhagen)

  • Jian-Yang Chen

    (BGI Research
    BGI Research)

  • Yingying Zhang

    (BGI Research
    BGI Research)

  • Yanan Li

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Xianghui Zhang

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Qian Wang

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Kaiqiang Liu

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Yu-Yan Liu

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

  • Yue Pang

    (Liaoning Normal University)

  • Shanshan Liu

    (BGI Research
    MGI Tech)

  • Guangyi Fan

    (BGI Research
    BGI Research
    BGI Research)

  • Changwei Shao

    (Chinese Academy of Fishery Sciences
    Qingdao Marine Science and Technology Center)

Abstract

Lymphocyte receptors independently evolved in both jawed and jawless vertebrates with similar adaptive immune responses. However, the diversity of functional subtypes and molecular architecture in jawless vertebrate lymphocytes, comparable to jawed species, is not well defined. Here, we profile the gills, intestines, and blood of the lamprey, Lampetra morii, with single-cell RNA sequencing, using a full-length transcriptome as a reference. Our findings reveal higher tissue-specific heterogeneity among T-like cells in contrast to B-like cells. Notably, we identify a unique T-like cell subtype expressing a homolog of the nonlymphoid hematopoietic growth factor receptor, MPL-like (MPL-L). These MPL-L+ T-like cells exhibit features distinct from T cells of jawed vertebrates, particularly in their elevated expression of hematopoietic genes. We further discovered that MPL-L+ VLRA+ T-like cells are widely present in the typhlosole, gill, liver, kidney, and skin of lamprey and they proliferate in response to both a T cell mitogen and recombinant human thrombopoietin. These findings provide new insights into the adaptive immune response in jawless vertebrates, shedding new light on the evolution of adaptive immunity.

Suggested Citation

  • Yingyi Huang & Xiang Liu & Shuo Li & Chen Li & Hong-Yan Wang & Qun Liu & Jian-Yang Chen & Yingying Zhang & Yanan Li & Xianghui Zhang & Qian Wang & Kaiqiang Liu & Yu-Yan Liu & Yue Pang & Shanshan Liu &, 2024. "Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51763-2
    DOI: 10.1038/s41467-024-51763-2
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    References listed on IDEAS

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