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Evolutionary implications of a third lymphocyte lineage in lampreys

Author

Listed:
  • Masayuki Hirano

    (Emory University, 1462 Clifton Road North-East, Atlanta, Georgia 30322, USA)

  • Peng Guo

    (Emory University, 1462 Clifton Road North-East, Atlanta, Georgia 30322, USA
    Present address: Novo Nordisk Research Centre China, 20 Life Science Park Road, Beijing 102206, China.)

  • Nathanael McCurley

    (Emory University, 1462 Clifton Road North-East, Atlanta, Georgia 30322, USA)

  • Michael Schorpp

    (Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, Freiburg D-79108, Germany)

  • Sabyasachi Das

    (Emory University, 1462 Clifton Road North-East, Atlanta, Georgia 30322, USA)

  • Thomas Boehm

    (Max Planck Institute of Immunobiology and Epigenetics, Stuebeweg 51, Freiburg D-79108, Germany)

  • Max D. Cooper

    (Emory University, 1462 Clifton Road North-East, Atlanta, Georgia 30322, USA)

Abstract

Cells expressing variable lymphocyte receptor C (VLRC) genes that encode VLRC receptors, which are used by jawless vertebrates to react with antigens, are defined as a second T-cell-like lymphocyte subset (the first being VLRA-bearing cells); distinct properties of these two T-cell-like subsets are reminiscent of the distinction between αβ and γδ T cells in jawed vertebrates.

Suggested Citation

  • Masayuki Hirano & Peng Guo & Nathanael McCurley & Michael Schorpp & Sabyasachi Das & Thomas Boehm & Max D. Cooper, 2013. "Evolutionary implications of a third lymphocyte lineage in lampreys," Nature, Nature, vol. 501(7467), pages 435-438, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7467:d:10.1038_nature12467
    DOI: 10.1038/nature12467
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    Cited by:

    1. Guillem Sanchez Sanchez & Maria Papadopoulou & Abdulkader Azouz & Yohannes Tafesse & Archita Mishra & Jerry K. Y. Chan & Yiping Fan & Isoline Verdebout & Silvana Porco & Frédérick Libert & Florent Gin, 2022. "Identification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Guillem Sanchez Sanchez & Stephan Emmrich & Maria Georga & Ariadni Papadaki & Sofia Kossida & Andrei Seluanov & Vera Gorbunova & David Vermijlen, 2024. "Invariant γδTCR natural killer-like effector T cells in the naked mole-rat," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Yingyi Huang & Xiang Liu & Shuo Li & Chen Li & Hong-Yan Wang & Qun Liu & Jian-Yang Chen & Yingying Zhang & Yanan Li & Xianghui Zhang & Qian Wang & Kaiqiang Liu & Yu-Yan Liu & Yue Pang & Shanshan Liu &, 2024. "Discovery of an unconventional lamprey lymphocyte lineage highlights divergent features in vertebrate adaptive immune system evolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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