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Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy

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  • Eunhye Cho

    (Seoul National University College of Medicine
    Seoul National University College of Natural Sciences)

  • Jii Kwon

    (Seoul National University College of Natural Sciences)

  • Gyuwon Lee

    (Seoul National University College of Natural Sciences)

  • Jiwoo Shin

    (Seoul National University College of Medicine
    Seoul National University College of Natural Sciences)

  • Hyunsu Lee

    (Pusan National University School of Medicine)

  • Suk-Ho Lee

    (Seoul National University College of Medicine
    Seoul National University College of Natural Sciences)

  • Chun Kee Chung

    (Seoul National University Hospital
    Seoul National University Medical Research Center)

  • Jaeyoung Yoon

    (Seoul National University College of Medicine
    Harvard Medical School)

  • Won-Kyung Ho

    (Seoul National University College of Medicine
    Seoul National University College of Natural Sciences)

Abstract

Focal cortical dysplasia type I (FCD I) is the most common cause of pharmaco-resistant epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I, we obtained tissue resected from patients with FCD I epilepsy, and from tumor patients as control. Using whole-cell patch clamp in acute human brain slices, we investigated the cellular properties of fast-spiking interneurons (FSINs) and pyramidal neurons (PNs) within the ictal onset zone. In FCD I epilepsy, FSINs exhibited lower firing rates from slower repolarization and action potential broadening, while PNs had increased firing. Importantly, excitatory synaptic drive of FSINs increased progressively with the scale of cortical activation as a general property across species, but this relationship was inverted towards net inhibition in FCD I epilepsy. Further comparison with intracranial electroencephalography (iEEG) from the same patients revealed that the spatial extent of pathological high-frequency oscillations (pHFO) was associated with synaptic events at FSINs.

Suggested Citation

  • Eunhye Cho & Jii Kwon & Gyuwon Lee & Jiwoo Shin & Hyunsu Lee & Suk-Ho Lee & Chun Kee Chung & Jaeyoung Yoon & Won-Kyung Ho, 2024. "Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51065-7
    DOI: 10.1038/s41467-024-51065-7
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    1. Yousheng Shu & Andrea Hasenstaub & David A. McCormick, 2003. "Turning on and off recurrent balanced cortical activity," Nature, Nature, vol. 423(6937), pages 288-293, May.
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